Search Results - "Redondo, Roger L."

Creating a False Memory in the Hippocampus by Ramirez, Steve, Liu, Xu, Lin, Pei-Ann, Suh, Junghyup, Pignatelli, Michele, Redondo, Roger L., Ryan, Tomás J., Tonegawa, Susumu

“…Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram—bearing cells in the hippocampus. Dentate gyrus…”
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Making memories last: the synaptic tagging and capture hypothesis by Morris, Richard G. M, Redondo, Roger L

“…Key Points The fate of a memory is not determined at the time of encoding, and this can be explained by the susceptibility of synaptic plasticity to modulation…”
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Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout rats by Marashli, Samuel, Janz, Philipp, Redondo, Roger L

“…Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited understanding…”
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3D printed rodent skin-skull-brain model: A novel animal-free approach for neurosurgical training by Bainier, Marie, Su, Arel, Redondo, Roger L

“…In neuroscience, stereotactic brain surgery is a standard yet challenging technique for which laboratory and veterinary personnel must be sufficiently and…”
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Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory by Wang, Szu-Han, Redondo, Roger L., Morris, Richard G. M., Palmiter, Richard D.

“…Memory for inconsequential events fades, unless these happen before or after other novel or surprising events. However, our understanding of the…”
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Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders by Janz, Philipp, Bainier, Marie, Marashli, Samuel, Schoenenberger, Philipp, Valencia, Miguel, Redondo, Roger L.

“…Neurexins are presynaptic transmembrane proteins crucial for synapse development and organization. Deletion and missense mutations in all three Neurexin genes…”
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Synaptic Tagging and Capture: Differential Role of Distinct Calcium/Calmodulin Kinases in Protein Synthesis-Dependent Long-Term Potentiation by Redondo, Roger L, Okuno, Hiroyuki, Spooner, Patrick A, Frenguelli, Bruno G, Bito, Haruhiko, Morris, Richard G. M

“…Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting approximately 3 h (called early-LTP) will…”
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Identification and Manipulation of Memory Engram Cells by Liu, Xu, Ramirez, Steve, Redondo, Roger L, Tonegawa, Susumu

“…How memories are formed and stored in the brain remains a fascinating question in neuroscience. Here we discuss the memory engram theory, our recent attempt to…”
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Bidirectional switch of the valence associated with a hippocampal contextual memory engram by Redondo, Roger L., Kim, Joshua, Arons, Autumn L., Ramirez, Steve, Liu, Xu, Tonegawa, Susumu

“…An optogenetic approach in mice was used to investigate the neural mechanisms underlying memory valence association; dentate gyrus, but not amygdala, memory…”
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Engrams and circuits crucial for systems consolidation of a memory by Kitamura, Takashi, Ogawa, Sachie K., Roy, Dheeraj S., Okuyama, Teruhiro, Morrissey, Mark D., Smith, Lillian M., Redondo, Roger L., Tonegawa, Susumu

“…Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks…”
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Activating positive memory engrams suppresses depression-like behaviour by Ramirez, Steve, Liu, Xu, MacDonald, Christopher J., Moffa, Anthony, Zhou, Joanne, Redondo, Roger L., Tonegawa, Susumu

“…Acute re-activation of a positive memory engram suppresses depression-like behaviour in mice exposed to chronic stress, mediated by a…”
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Clinically-probed mechanisms of action in Fragile-X syndrome fail to normalize translational EEG phenotypes in Fmr1 knockout mice by Janz, Philipp, Bainier, Marie, Marashli, Samuel, Gross, Simon, Redondo, Roger L.

“…Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by Fragile X Messenger Ribonucleoprotein (FMRP) deficiency. Electroencephalogram (EEG) changes…”
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Workflow for the unsupervised clustering of sleep stages identifies light and deep sleep in electrophysiological recordings in mice by Cusinato, Riccardo, Gross, Simon, Bainier, Marie, Janz, Philipp, Schoenenberger, Philipp, Redondo, Roger L.

“…Sleep physiology plays a critical role in brain development and aging. Accurate sleep staging, which categorizes different sleep states, is fundamental for…”
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Age-dependent deficits of auditory brainstem responses in juvenile Neurexin1α knockout rats by Marashli, Samuel, Janz, Philipp, Redondo, Roger L

“…Abnormal sensory processing is core to neuropsychiatric and neurodevelopmental disorders, such as schizophrenia and autism spectrum disorders. Developing…”
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GABA B R activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits by Janz, Philipp, Nicolas, Maria Jesus, Redondo, Roger L, Valencia, Miguel

“…Cognitive deficits and impaired sensory processing are hallmarks of several neurodevelopmental and neuropsychiatric disorders. N-methyl-d-aspartate receptor…”
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GABABR activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits by Janz, Philipp, Nicolas, Maria Jesus, Redondo, Roger L., Valencia, Miguel

“…Cognitive deficits and impaired sensory processing are hallmarks of several neurodevelopmental and neuropsychiatric disorders. N‐methyl‐d‐aspartate receptor…”
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Glutamatergic and GABAergic Receptor Modulation Present Unique Electrophysiological Fingerprints in a Concentration-Dependent and Region-Specific Manner by Gonzalez-Burgos, Irene, Bainier, Marie, Gross, Simon, Schoenenberger, Philipp, Ochoa, José A, Valencia, Miguel, Redondo, Roger L

“…Brain function depends on complex circuit interactions between excitatory and inhibitory neurons embedded in local and long-range networks. Systemic…”
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Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1[alpha] knockout rats by Marashli, Samuel, Janz, Philipp, Redondo, Roger L

“…Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited understanding…”
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Pedal neuron 3 serves a significant role in effecting turning during crawling by the marine slug Tritonia diomedea (Bergh) by Redondo, Roger L, Murray, James A

“…The marine nudibranch Tritonia diomedea crawls using its ciliated foot surface as the sole means of propulsion. Turning while crawling involves raising a small…”
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GABAB R activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits by Janz, Philipp, Nicolas, Maria Jesus, Redondo, Roger L, Valencia, Miguel

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