Search Results - "Redmond, T. M."

Rpe65 is necessary for production of 11- cis -vitamin A in the retinal visual cycle by Redmond, T. Michael, Lee, Eric, Ma, Jian-Xing, Yu, Shirley, Bok, Dean, Hamasaki, Duco, Crouch, Rosalie K, Chen, Ning, Goletz, Patrice, Pfeifer, Karl

“…Mutation of RPE65 can cause severe blindness from birth or early childhood, and RPE65 protein is associated with retinal pigment epithelium (RPE) vitamin A…”
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Effect of Rpe65 Knockout on Accumulation of Lipofuscin Fluorophores in the Retinal Pigment Epithelium by Katz, Martin L, Redmond, T. Michael

“…In all mammalian species examined to date the retinal pigment epithelium (RPE) has been found to accumulate autofluorescent lysosomal storage bodies…”
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Protection of Rpe65 -deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration by Redmond, T. Michael, Remé, Charlotte E, Hafezi, Farhad, Yu, Shirley, Wenzel, Andreas, Grimm, Christian

“…Light-induced apoptosis of photoreceptors represents an animal model for retinal degeneration. Major human diseases that affect vision, such as age-related…”
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Technical brief: subretinal injection and electroporation into adult mouse eyes by Johnson, Christiana J, Berglin, Lennart, Chrenek, Micah A, Redmond, T M, Boatright, Jeffrey H, Nickerson, John M

“…Our goal was to improve and standardize the procedure for subretinal injection of mouse eyes. Also, we wished to optimize conditions for electroporation of…”
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In Vivo Gene Therapy in Young and Adult RPE65−/− Dogs Produces Long-Term Visual Improvement by Narfström, K., Katz, M. L., Ford, M., Redmond, T. M., Rakoczy, E., Bragadóttir, R.

“…Defects in the RPE65 gene, which is selectively expressed in the retinal pigment epithelium (RPE), result in blindness and gradual photoreceptor cell…”
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Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro by HAMEL, C. P, TSILOU, E, PFEFFER, B. A, HOOKS, J. J, DETRICK, B, REDMOND, T. M

“…Studies reported previously from this laboratory have shown that microsomal membranes of the vertebrate retinal pigment epithelium (RPE) contain an…”
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Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65 −/− mice by Daniels, D.M, Stoddart, C.W, Martin-Iverson, M.T, Lai, C.-M, Redmond, T.M, Rakoczy, P.E

“…Light entrainment of circadian rhythms is mediated by classical “visual” photoreceptors (rods and cones) as well as “nonvisual” photoreceptive elements…”
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Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP) by SANUI, H, REDMOND, T. M, KOTAKE, S, WIGGERT, B, LI-HONG HU, MARGALIT, H, BERZOFSKY, J. A, CHADER, G. J, GERY, I

“…Interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein specific for the retina and pineal gland, induces inflammatory changes in these two organs…”
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Interphotoreceptor retinoid-binding protein. Gene characterization, protein repeat structure, and its evolution by Borst, D.E, Redmond, T.M, Elser, J.E, Gonda, M.A, Wiggert, B, Chader, G.J, Nickerson, J.M

“…The gene for bovine interphotoreceptor retinoid-binding protein (IRBP) has been cloned, and its nucleotide sequence has been determined. The IRBP gene is about…”
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Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase by Redmond, T. Michael, Gentleman, Susan, Duncan, Todd, Yu, Shirley, Wiggert, Barbara, Gantt, Elisabeth, Cunningham, Francis X.

“…We have identified from mouse the first mammalian β-carotene 15,15′-dioxygenase (β-CD), a crucial enzyme in development and metabolism that governs the de novo…”
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A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina by Hamel, C P, Tsilou, E, Harris, E, Pfeffer, B A, Hooks, J J, Detrick, B, Redmond, T M

“…In the vertebrate retina, the retinal pigment epithelium (RPE) performs specific functions critical to the normal process of vision. Although some of these…”
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What can we learn about age-related macular degeneration from other retinal diseases? by Zack, D J, Dean, M, Molday, R S, Nathans, J, Redmond, T M, Stone, E M, Swaroop, A, Valle, D, Weber, B H

“…Age-related macular degeneration (AMD) is increasingly recognized as a complex genetic disorder in which one or more genes contribute to an individual's…”
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Coverage of multiple sclerosis in the Irish written media by O'Donnell, Martin M., Redmond, Janice M.T.

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New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis by Redmond, T. Michael, Zrenner, Eberhart, Wenzel, Andreas, Remé, Charlotte E, Jaissle, Gesine, Biel, Martin, Fariss, Robert N, Humphries, Peter, Ståhlberg, Fredrik, Grimm, Christian, Seeliger, Mathias W, Hofmann, Franz, Friedburg, Christoph, Guo, Hao

“…Leber congenital amaurosis (LCA) is the most serious form of the autosomal recessive childhood-onset retinal dystrophies. Mutations in the gene encoding RPE65,…”
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Mutations in RPE65 cause Leber's congenital amaurosis by Harris, Eddie, Claustres, Mireille, Liu, Su-Yan, Zrenner, Eberhart, Amalric, Pierre, Hamel, Christian P, Griffoin, Jean-Michel, Bareil, Corinne, Redmond, T. Michael, Marlhens, Françoise, Arnaud, Bernard, Eliaou, Claudie

“…RPE65 is a 65-kD protein specific to the retinal pigment epithelium (RPE; refs 1,2), a monolayer epithelium in close contact with the photoreceptor outer…”
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Endogenous fatty acids are covalently and noncovalently bound to interphotoreceptor retinoid-binding protein in the monkey retina by Bazan, N G, Reddy, T S, Redmond, T M, Wiggert, B, Chader, G J

“…Interphotoreceptor retinoid-binding protein (IRBP) purified from monkey interphotoreceptor matrix contains relatively high concentrations of endogenous fatty…”
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Intrachoroidal Neovascularization in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium by Schwesinger, Catherine, Yee, Charles, Rohan, Richard M., Joussen, Antonia M., Fernandez, Antonio, Meyer, Tobias N., Poulaki, Vassiliki, Ma, Joseph J.K., Redmond, T. Michael, Liu, Suyan, Adamis, Anthony P., D’Amato, Robert J.

“…Choroidal neovascularization in age-related macular degeneration is a frequent and poorly treatable cause of vision loss in elderly Caucasians. This choroidal…”
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Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein by Gery, I, Wiggert, B, Redmond, TM, Kuwabara, T, Crawford, MA, Vistica, BP, Chader, GJ

“…Rats immunized with microgram amounts of interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal…”
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The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3 by Hamel, C P, Jenkins, N A, Gilbert, D J, Copeland, N G, Redmond, T M

“…The human and murine chromosomal localization for the gene for the retinal pigment epithelium-specific protein RPE65 was determined. Using interspecific…”
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11-cis-Retinal Reduces Constitutive Opsin Phosphorylation and Improves Quantum Catch in Retinoid-deficient Mouse Rod Photoreceptors by Ablonczy, Zsolt, Crouch, Rosalie K, Goletz, Patrice W, Redmond, T Michael, Knapp, Daniel R, Ma, Jian-Xing, Rohrer, Barbel

“…Rpe65 −/− mice produce minimal amounts of 11- cis -retinal, the ligand necessary for the formation of photosensitive visual pigments. Therefore, the…”
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