Search Results - "Redmond, Michael"

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration by Lenis, Tamara L., Hu, Jane, Ng, Sze Yin, Jiang, Zhichun, Sarfare, Shanta, Lloyd, Marcia B., Esposito, Nicholas J., Samuel, William, Jaworski, Cynthia, Bok, Dean, Finnemann, Silvia C., Radeke, Monte J., Redmond, T. Michael, Travis, Gabriel H., Radu, Roxana A.

“…Recessive Stargardt disease (STGD1) is an inherited blinding disorder caused by mutations in the Abca4 gene. ABCA4 is a flippase in photoreceptor outer…”
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Septic arthritis of the lumbar facet joint. Case and literature review by Yoon, Joseph, Efendy, Johnny, Redmond, Michael J.

“…•Septic arthritis of facet joints is very rare.•Most cases are associated with raised inflammatory markers.•Normal inflammatory markers should not be used as a…”
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Pretreatment of human retinal pigment epithelial cells with sterculic acid forestalls fenretinide-induced apoptosis by William, Samuel, Duncan, Todd, Redmond, T. Michael

“…The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase…”
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CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function by Sethna, Saumil, Scott, Patrick A., Giese, Arnaud P. J., Duncan, Todd, Jian, Xiaoying, Riazuddin, Sheikh, Randazzo, Paul A., Redmond, T. Michael, Bernstein, Steven L., Riazuddin, Saima, Ahmed, Zubair M.

“…Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder. Although molecular mechanisms remain elusive, deficits in autophagy have…”
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Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration by Huber, Gesine, Beck, Susanne C, Grimm, Christian, Sahaboglu-Tekgoz, Ayse, Paquet-Durand, Francois, Wenzel, Andreas, Humphries, Peter, Redmond, T. Michael, Seeliger, Mathias W, Fischer, M. Dominik

“…Spectral domain optical coherence tomography (SD-OCT) allows cross-sectional visualization of retinal structures in vivo. Here, the authors report the efficacy…”
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The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function by Uppal, Sheetal, Liu, Tingting, Poliakov, Eugenia, Gentleman, Susan, Redmond, T. Michael

“…Association with the endoplasmic reticulum (ER) membrane is a critical requirement for the catalytic function of RPE65. Several studies have investigated the…”
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Proposed therapy, developed in a Pcdh15 -deficient mouse, for progressive loss of vision in human Usher syndrome by Sethna, Saumil, Zein, Wadih M, Riaz, Sehar, Giese, Arnaud Pj, Schultz, Julie M, Duncan, Todd, Hufnagel, Robert B, Brewer, Carmen C, Griffith, Andrew J, Redmond, T Michael, Riazuddin, Saima, Friedman, Thomas B, Ahmed, Zubair M

“…Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder…”
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Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells by Uppal, Sheetal, Postnikova, Olga, Villasmil, Rafael, Rogozin, Igor B, Bocharov, Alexander V, Eggerman, Thomas L, Poliakov, Eugenia, Redmond, T Michael

“…Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19…”
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The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA by Postnikova, Olga A., Uppal, Sheetal, Huang, Weiliang, Kane, Maureen A., Villasmil, Rafael, Rogozin, Igor B., Poliakov, Eugenia, Redmond, T. Michael

“…The SARS-CoV-2 Spike glycoprotein (S protein) acquired a unique new 4 amino acid -PRRA- insertion sequence at amino acid residues (aa) 681–684 that forms a new…”
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Pilot-administered anaesthesia and the Royal Flying Doctor Service of Australia: An interview with Captain Keith Galloway by Redmond, Michael J, Potter, Thomas A, Bradley, James P

“…The lack of radio navigational aids in early Royal Flying Doctor Service aircraft in Australia occasionally resulted in aircraft being stranded at a remote…”
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Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration by Ma, Hongwei, Thapa, Arjun, Morris, Lynsie, Redmond, T. Michael, Baeh, Wolfgang, Ding, Xi-Qin

“…Cone phototransduction and survival of cones in the human macula is essential for color vision and for visual acuity. Progressive cone degeneration in…”
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Mutation of Key Residues of RPE65 Abolishes Its Enzymatic Role as Isomerohydrolase in the Visual Cycle by Redmond, T. Michael, Poliakov, Eugenia, Yu, Shirley, Tsai, Jen-Yue, Lu, Zhongjian, Gentleman, Susan, Nathans, Jeremy

“…RPE65 is essential for isomerization of vitamin A to the visual chromophore. Mutations in RPE65 cause early-onset blindness, and Rpe65-deficient mice lack…”
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Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins by Poliakov, Eugenia, Soucy, Joseph, Gentleman, Susan, Rogozin, Igor B., Redmond, T. Michael

“…Here we describe a new family of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) clade, which contains lancelet, nematode, and…”
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Palmitoylation of Metazoan Carotenoid Oxygenases by Uppal, Sheetal, Rogozin, Igor B, Redmond, T Michael, Poliakov, Eugenia

“…Abundant in nature, carotenoids are a class of fat-soluble pigments with a polyene tetraterpenoid structure. They possess antioxidant properties and their…”
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Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway by Kutty, R. Krishnan, Nagineni, Chandrasekharam N., Samuel, William, Vijayasarathy, Camasamudram, Hooks, John J., Redmond, T. Michael

“…► Combination of IFN-γ, TNF-α and IL-1β increased microRNA-155 expression in human retinal pigment epithelial cells. ► Two putative STAT1 binding elements are…”
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Intracranial Management of Perineural Spread in the Trigeminal Nerve by Redmond, Michael J., Panizza, Benedict J.

“…Abstract Since the mid-1960s surgeons have attempted to cure intracranial perineural spread (PNS) of cutaneous malignancies. Untreated patients with trigeminal…”
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Xanthophylls Modulate Palmitoylation of Mammalian β-Carotene Oxygenase 2 by Uppal, Sheetal, Dergunov, Sergey A, Zhang, Weiyu, Gentleman, Susan, Redmond, T Michael, Pinkhassik, Eugene, Poliakov, Eugenia

“…An extensive body of work has documented the antioxidant role of xanthophylls (lutein and zeaxanthin) in human health and specifically how they provide…”
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Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration by Ma, Hongwei, Yang, Fan, Butler, Michael R., Belcher, Joshua, Redmond, T. Michael, Placzek, Andrew T., Scanlan, Thomas S., Ding, Xi‐Qin

“…ABSTRACT Thyroid hormone (TH) signaling regulates cell proliferation, differentiation, and metabolism. Recent studies have implicated TH signaling in cone…”
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A data-driven software tool for enabling cooperative information sharing among police departments by Redmond, Michael, Baveja, Alok

“…Police departments utilize information technology for combating crime, however, mostly for tactical purposes. This paper presents an Artificial-Intelligence…”
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Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1 by Poliakov, Eugenia, Samuel, William, Duncan, Todd, Gutierrez, Danielle B, Mata, Nathan L, Redmond, T Michael

“…The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity,…”
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