Search Results - "Redmond, D.E."

Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson’s disease by Redmond, D.E, Vinuela, A, Kordower, J.H, Isacson, O

“…Abstract Surgeries involving transplantation of fetal dopamine (DA) neurons into the caudate–putamen of patients with Parkinson’s disease (PD) have been…”
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Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease by Morrow, B.A, Roth, R.H, Redmond, D.E, Elsworth, J.D

“…Abstract Methamphetamine is a CNS stimulant with limited therapeutic indications, but is widely abused. Short-term exposure to higher doses, or long-term…”
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Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment by Elsworth, J.D., Taylor, J.R., Sladek, J.R., Collier, T.J., Redmond, D.E., Roth, R.H.

“…Despite widespread use of the primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease, there is a paucity of data concerning…”
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Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF by Redmond Jr, D.E., Elsworth, J.D., Roth, R.H., Leranth, C., Collier, T.J., Blanchard, B., Bjugstad, K.B., Samulski, R.J., Aebischer, P., Sladek Jr, J.R.

“…In spite of partial success in treating Parkinson's disease by using ectopically placed grafts of dopamine‐producing cells, restoration of the original…”
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Neurobiological mechanisms in human anxiety. Evidence supporting central noradrenergic hyperactivity by Charney, D S, Redmond, Jr, D E

“…Preclinical studies in laboratory rodents and non-human primates have led to the hypothesis that noradrenergic hyperactivity is associated with some human…”
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Tyrosine hydroxylase immunoreactivity and monoamine and metabolite levels in cryopreserved human fetal ventral mesencephalon by Kontur, P J, Leranth, C, Redmond, Jr, D E, Roth, R H, Robbins, R J

“…Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with…”
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MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys by Elsworth, J D, Deutch, A Y, Redmond, Jr, D E, Sladek, Jr, J R, Roth, R H

“…Dopamine (DA) and homovanillic acid (HVA) concentrations were measured in subregions of substantia nigra, ventral tegmental area and retrorubral field in…”
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Susceptibility to a parkinsonian toxin varies during primate development by Morrow, B.A., Roth, R.H., Redmond, D.E., Diano, S., Elsworth, J.D.

“…Symptoms of Parkinson's disease typically emerge later in life when loss of nigrostriatal dopamine neuron function exceeds the threshold of compensatory…”
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Genome wide expression analysis of human neural stem cells in vitro by Wakeman, D.R., Snyder, E.Y., Redmond, D.E., Loring, J.F., Mueller, F.J.

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Cryopreservation, Culture, and Transplantation of Human Fetal Mesencephalic Tissue into Monkeys by Redmond, D. E., Naftolin, F., Collier, T. J., Leranth, C., Robbins, R. J., Sladek, C. D., Roth, R. H., Sladek, J. R.

“…Studies in animals suggest that fetal neural grafts might restore lost neurological function in Parkinson's disease. In monkeys, such grafts survive for many…”
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Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys by Taylor, J.R., Elsworth, J.D., Lawrence, M.S., Sladek, J.R., Roth, R.H., Redmond, D.E.

“…Previous studies have suggested a dopaminergic regulation of eye blink rates in human and nonhuman primates. Blockade of either dopamine (DA) D1 or DA D2…”
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AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons by Elsworth, J.D., Redmond, D.E., Leranth, C., Bjugstad, K.B., Sladek, J.R., Collier, T.J., Foti, S.B., Samulski, R.J., Vives, K.P., Roth, R.H.

“…Neural transplantation offers the potential of treating Parkinson's disease by grafting fetal dopamine neurons to depleted regions of the brain. However,…”
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Efficiency of gene delivery among AAV serotypes in primate brain by Markakis, E.A., Leranth, C., Bober, J., Samulski, R.J., Rabinowitz, J., Zhou, X., Vives, K., Redmond, D.E.

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Aged monkeys as a partial model for Parkinson's disease by Hurley, P.J., Elsworth, J.D., Whittaker, M.C., Roth, R.H., Redmond, D.E.

“…Parkinson's Disease (PD) and the natural aging process share a number of biochemical mechanisms, including reduced function of dopaminergic systems. The…”
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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6 by Towne, C, Schneider, B L, Kieran, D, Redmond, D E, Aebischer, P

“…Retrograde transport of viral vectors in the rodent spinal cord provides a powerful means to administer a therapeutic transgene from the innervated…”
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Use of ultrasound to assess fetal age and pregnancy outcomes in green monkeys held in social colonies at St. Kitts Biomedical Research Foundation by Redmond, D.E., Christian, Mildred S., Coon, D. James, Evans, Lawrence

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Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits by Jentsch, J.D., Taylor, J.R., Elsworth, J.D., Redmond, D.E., Roth, R.H.

“…Long-term exposure to the psychotomimetic drug phencyclidine produces prefrontal cortical cognitive and dopaminergic dysfunction in rats and monkeys, effects…”
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Social and nonsocial behaviours of sex- and age-matched enclosed and free-ranging rhesus monkeys (Macaca mulatta) by Baulu, J, Redmond, Jr, D E

“…The behavioural profiles (time budgeting of social and nonsocial activities) and the frequencies of major social interactions of corral-enclosed rhesus monkeys…”
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Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study by Elsworth, J.D, Brittan, M.S, Taylor, J.R, Sladek, J.R, Redmond, D.E, Innis, R.B, Zea-Ponce, Y, Roth, R.H

“…Although neural transplantation holds promise as a treatment for Parkinson's disease, parkinsonian primates have generally exhibited inconsistent and…”
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Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey ( Cercopithecus aethiops sabaeus) by Taylor, J.R, Elsworth, J.D, Roth, R.H, Sladek, J.R, Redmond, D.E

“…The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces parkinsonian neurochemical and functional deficits in human and non-human primates…”
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