Search Results - "Redmond, D"

Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates by Elsworth, John D., Jentsch, J. David, VandeVoort, Catherine A., Roth, Robert H., Jr, D. Eugene Redmond, Leranth, Csaba

“…► The impact of environmental exposure to BPA on CNS development in primates is unknown. ► Pregnant monkeys were exposed each day during the last trimester to…”
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Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates by Collier, Timothy J, Redmond, Jr, D Eugene, Steece-Collier, Kathy, Lipton, Jack W, Manfredsson, Fredric P

“…Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson's disease (PD), leading to the…”
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Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles by Li, Wuping, Asokan, Aravind, Wu, Zhijian, Van Dyke, Terry, DiPrimio, Nina, Johnson, Jarrod S, Govindaswamy, Lakshmanan, Agbandje-McKenna, Mavis, Leichtle, Stefan, Eugene Redmond Jr, D, McCown, Thomas J, Petermann, Kimberly B, Sharpless, Norman E, Samulski, Richard J

“…We report a DNA shuffling–based approach for developing cell type–specific vectors through directed evolution. Capsid genomes of adeno-associated virus (AAV)…”
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Generating Human Organs via Interspecies Chimera Formation: Advances and Barriers by De Los Angeles, Alejandro, Pho, Nam, Redmond, Jr, D Eugene

“…The shortage of human organs for transplantation is a devastating medical problem. One way to expand organ supply is to derive functional organs from…”
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Aridity drives spatiotemporal patterns of masting across the latitudinal range of a dryland conifer by Wion, Andreas P., Weisberg, Peter J., Pearse, Ian S., Redmond, Miranda D.

“…Masting, or the synchronous and irregular production of seed crops, is controlled by environmental conditions and resource budgets. Increasing temperatures and…”
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An assessment of temporal variability in mast seeding of North American Pinaceae by LaMontagne, Jalene M, Redmond, Miranda D, Wion, Andreas P, Greene, David F

“…Our overall objective is to synthesize mast-seeding data on North American Pinaceae to detect characteristic features of reproduction (i.e. development cycle…”
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Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease by Wolff, Erin F., Mutlu, Levent, Massasa, Efi E., Elsworth, John D., Eugene Redmond, D., Taylor, Hugh S.

“…Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell‐replacement therapies have…”
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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6 by Towne, C, Schneider, B L, Kieran, D, Redmond, D E, Aebischer, P

“…Retrograde transport of viral vectors in the rodent spinal cord provides a powerful means to administer a therapeutic transgene from the innervated…”
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Woodland resilience to regional drought: Dominant controls on tree regeneration following overstorey mortality by Redmond, Miranda D., Weisberg, Peter J., Cobb, Neil S., Clifford, Michael J.

“…1. Drought events occurring under warmer temperatures (i.e. "hotter droughts") have resulted in widespread tree mortality across the globe, and may result in…”
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Breast implant illness: scientific evidence of its existence by Cohen Tervaert, J W, Mohazab, N, Redmond, D, van Eeden, C, Osman, M

“…More than one million breast augmentation procedures using silicone breast implants (SBI) have been performed worldwide. Adverse events of SBI include local…”
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Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells by Redmond, D. Eugene Jr, Bjugstad, Kimberly B, Teng, Yang D, Ourednik, Vaclav, Ourednik, Jitka, Wakeman, Dustin R, Parsons, Xuejun H, Gonzalez, Rodolfo, Blanchard, Barbara C, Kim, Seung U, Gu, Zezong, Lipton, Stuart A, Markakis, Eleni A, Roth, Robert H, Elsworth, John D, Sladek, John R. Jr, Sidman, Richard L, Snyder, Evan Y

“…Stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including Parkinson's disease (PD), in which…”
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ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state by De Los Angeles, Alejandro, Elsworth, John D., Redmond, D. Eugene

“…Generating human organs inside interspecies chimeras might one day produce patient-specific organs for clinical applications, but further advances in…”
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Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease by Daadi, Marcel M, Grueter, Brad A, Malenka, Robert C, Redmond, Jr, D Eugene, Steinberg, Gary K

“…The use of human embryonic stem cells (hESCs) to repair diseased or injured brain is promising technology with significant humanitarian, societal and economic…”
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Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease by Gonzalez, Rodolfo, Garitaonandia, Ibon, Crain, Andrew, Poustovoitov, Maxim, Abramihina, Tatiana, Noskov, Alexander, Jiang, Chuan, Morey, Robert, Laurent, Louise C, Elsworth, John D, Snyder, Evan Y, Redmond, Jr, D Eugene, Semechkin, Ruslan

“…Recent studies indicate that human pluripotent stem cell (PSC)-based therapies hold great promise in Parkinson's disease (PD). Clinical studies have shown that…”
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Low circulating levels of bisphenol-A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys by Elsworth, John D., Jentsch, James D., Groman, Stephanie M., Roth, Robert H., Redmond Jr, Eugene D., Leranth, Csaba

“…Bisphenol‐A (BPA) is widely used in the manufacture of plastics, epoxy resins, and certain paper products. A majority of the population in the developed world…”
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Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges by De Los Angeles, Alejandro, Hyun, Insoo, Latham, Stephen R, Elsworth, John D, Redmond, Jr, D Eugene

“…The search for a better animal model to simulate human disease has been a "holy grail" of biomedical research for decades. Recent identification of different…”
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Tree regeneration following drought- and insect-induced mortality in piñon–juniper woodlands by Redmond, Miranda D., Barger, Nichole N.

“…Widespread piñon (Pinus edulis) mortality occurred across the southwestern USA during 2002–2003 in response to drought and bark beetle infestations. Given the…”
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Impaired Arm Function and Finger Dexterity in a Nonhuman Primate Model of Stroke: Motor and Cognitive Assessments by McEntire, Caleb R.S, Choudhury, Gourav R, Torres, April, Steinberg, Gary K, Redmond, D Eugene, Daadi, Marcel M

“…BACKGROUND AND PURPOSE—Ischemic stroke is the leading cause of upper extremity motor impairments. Although several well-characterized experimental stroke…”
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Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development by Bloch, Jocelyne, Kaeser, Mélanie, Sadeghi, Yalda, Rouiller, Eric M., Redmond JR, D. Eugene, Brunet, Jean-François

“…We have demonstrated that cortical cell autografts might be a useful therapy in two monkey models of neurological disease: motor cortex lesion and Parkinson's…”
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Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease by Gonzalez, Rodolfo, Garitaonandia, Ibon, Poustovoitov, Maxim, Abramihina, Tatiana, McEntire, Caleb, Culp, Ben, Attwood, Jordan, Noskov, Alexander, Christiansen-Weber, Trudy, Khater, Marwa, Mora-Castilla, Sergio, To, Cuong, Crain, Andrew, Sherman, Glenn, Semechkin, Andrey, Laurent, Louise C, Elsworth, John D, Sladek, John, Snyder, Evan Y, Redmond, Jr, D Eugene, Kern, Russell A

“…Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown…”
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