Search Results - "Redmond, Aisling"

The efficacy and complications of retropubic tension‐free vaginal tapes after 20 years: A prospective observational study by O'Leary, Bobby D., McCreery, Alexandra, Redmond, Aisling E., Keane, Declan P.

“…Objective Long‐term data regarding risks associated with tension‐free vaginal tapes (TVT) are sparse, and where available are limited to small numbers. We…”
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LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions by Roller, Maša, Stamper, Ericca, Villar, Diego, Izuogu, Osagie, Martin, Fergal, Redmond, Aisling M, Ramachanderan, Raghavendra, Harewood, Louise, Odom, Duncan T, Flicek, Paul

“…To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver,…”
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Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation by Redmond, Aisling M, Omarjee, Soleilmane, Chernukhin, Igor, Le Romancer, Muriel, Carroll, Jason S

“…HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to…”
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A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division by Stojic, Lovorka, Lun, Aaron T. L., Mascalchi, Patrice, Ernst, Christina, Redmond, Aisling M., Mangei, Jasmin, Barr, Alexis R., Bousgouni, Vicky, Bakal, Chris, Marioni, John C., Odom, Duncan T., Gergely, Fanni

“…Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into…”
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Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia by Nowicki-Osuch, Karol, Zhuang, Lizhe, Cheung, Tik Shing, Black, Emily L, Masqué-Soler, Neus, Devonshire, Ginny, Redmond, Aisling M, Freeman, Adam, di Pietro, Massimilliano, Pilonis, Nastazja, Januszewicz, Wladyslaw, O'Donovan, Maria, Tavaré, Simon, Shields, Jacqueline D, Fitzgerald, Rebecca C

“…Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach (GIM) are considered precursors for esophageal and gastric…”
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Pervasive lesion segregation shapes cancer genome evolution by Aitken, Sarah J., Anderson, Craig J., Connor, Frances, Pich, Oriol, Sundaram, Vasavi, Feig, Christine, Rayner, Tim F., Lukk, Margus, Aitken, Stuart, Luft, Juliet, Kentepozidou, Elissavet, Arnedo-Pac, Claudia, Beentjes, Sjoerd V., Davies, Susan E., Drews, Ruben M., Ewing, Ailith, Kaiser, Vera B., Khamseh, Ava, López-Arribillaga, Erika, Redmond, Aisling M., Santoyo-Lopez, Javier, Sentís, Inés, Talmane, Lana, Yates, Andrew D., Semple, Colin A., López-Bigas, Núria, Flicek, Paul, Odom, Duncan T., Taylor, Martin S.

“…Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion 1 , 2 . Here we reveal that most mutagenic DNA lesions are not…”
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Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution by Wong, Emily S., Schmitt, Bianca M., Kazachenka, Anastasiya, Thybert, David, Redmond, Aisling, Connor, Frances, Rayner, Tim F., Feig, Christine, Ferguson-Smith, Anne C., Marioni, John C., Odom, Duncan T., Flicek, Paul

“…Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor…”
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The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression by Qin, Li, Liao, Lan, Redmond, Aisling, Young, Leonie, Yuan, Yuhui, Chen, Hongwu, O'Malley, Bert W., Xu, Jianming

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer by Browne, Alacoque L., Charmsaz, Sara, Varešlija, Damir, Fagan, Ailis, Cosgrove, Nicola, Cocchiglia, Sinéad, Purcell, Siobhan, Ward, Elspeth, Bane, Fiona, Hudson, Lance, Hill, Arnold D., Carroll, Jason S., Redmond, Aisling M., Young, Leonie S.

“…Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate…”
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Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype by Varešlija, Damir, Ward, Elspeth, Purcell, Siobhan P., Cosgrove, Nicola S., Cocchiglia, Sinéad, O’Halloran, Philip J., Charmsaz, Sara, Bane, Fiona T., Brett, Francesca M., Farrell, Michael, Cryan, Jane, Beausang, Alan, Hudson, Lance, Turnbul, Arran K., Dixon, J. Michael, Hill, Arnold D. K., Priedigkeit, Nolan, Oesterreich, Steffi, Lee, Adrian V., Sims, Andrew H., Redmond, Aisling M., Carroll, Jason S., Young, Leonie S.

“…Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression…”
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Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors by Varešlija, Damir, McBryan, Jean, Fagan, Ailís, Redmond, Aisling M, Hao, Yuan, Sims, Andrew H, Turnbull, Arran, Dixon, J M, Ó Gaora, Peadar, Hudson, Lance, Purcell, Siobhan, Hill, Arnold D K, Young, Leonie S

“…Acquired resistance to aromatase inhibitor (AI) therapy is a major clinical problem in the treatment of breast cancer. The detailed mechanisms of how tumor…”
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Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence by REDMOND, Aisling M, BANE, Fiona T, STAFFORD, Anthony T, MCLLROY, Marie, DILLON, Mary F, CROTTY, Thomas B, HILL, Arnold D, YOUNG, Leonie S

“…Purpose: This study investigates the role of the p160 coactivators AIB1 and SRC-1 independently, and their interactions with the estrogen receptor, in the…”
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Enhancer-derived RNAs: 'spicing up' transcription programs by Redmond, Aisling M, Carroll, Jason S

“…Functional roles of enhancer‐derived RNAs (eRNAs) have so far been enigmatic. Two studies, recently published in Nature , establish the importance of eRNA…”
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Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients by Dillon, Mary F, Stafford, Anthony T, Kelly, Gabrielle, Redmond, Aisling M, McIlroy, Marie, Crotty, Thomas B, McDermott, E, Hill, Arnold D, Young, Leonie S

“…Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. Clinical and molecular studies implicate human epidermal growth factor receptor 2 (HER2)…”
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Defining and targeting transcription factors in cancer by Redmond, Aisling M, Carroll, Jason S

“…A report from the Keystone Symposium on Molecular and Cellular Biology, 'Deregulation of transcription in cancer: controlling cell fate decisions', Killarney,…”
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Recorded Rates of Trauma-Exposure in a Retrospective Epidemiologically Complete First-Episode Psychosis Cohort by Redmond, Aisling, Gaynor, Keith, Naughton, Sean, Clarke, Mary

“…Trauma plays an important role in the development and maintenance of psychosis. However, it is still under-examined in daily clinical practice. The current…”
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The efficacy and complications of retropubic tension‐free vaginal tapes after 20years: A prospective observational study by O'Leary, Bobby D, McCreery, Alexandra, Redmond, Aisling E, Keane, Declan P

“…ObjectiveLong‐term data regarding risks associated with tension‐free vaginal tapes (TVT) are sparse, and where available are limited to small numbers. We…”
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In vitro and in vivo assessments of the genotoxic potential of 3‐chloroallyl alcohol by Redmond, Aisling, Zhang, Fagen, Cheng, WanYun, Gollapudi, B. Bhaskar

“…3‐Chloroallyl alcohol (3‐CAA) can be found in the environment following the application of plant protection products. 3‐CAA is formed in groundwater following…”
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Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barrett's oesophagus surveillance: individual-level data analysis by Black, Emily L, Ococks, Emma, Devonshire, Ginny, Ng, Alvin Wei Tian, O'Donovan, Maria, Malhotra, Shalini, Tripathi, Monika, Miremadi, Ahmad, Freeman, Adam, Coles, Hannah, Fitzgerald, Rebecca C

“…Whether gastric metaplasia (GM) of the oesophagus should be considered as Barrett's oesophagus (BO) is controversial. Given concern intestinal metaplasia (IM)…”
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Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma by O’Shea, Robert, Withey, Samuel J., Owczarczyk, Kasia, Rookyard, Christopher, Gossage, James, Godfrey, Edmund, Jobling, Craig, Parsons, Simon L., Skipworth, Richard J. E., Goh, Vicky

“…Background Personalising management of primary oesophageal adenocarcinoma requires better risk stratification. Lack of independent validation of proposed…”
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