Search Results - "Redler, Rachel L"

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis by Proctor, Elizabeth A., Fee, Lanette, Tao, Yazhong, Redler, Rachel L., Fay, James M., Zhang, Yuliang, Lv, Zhengjian, Mercer, Ian P., Deshmukh, Mohanish, Lyubchenko, Yuri L., Dokholyan, Nikolay V.

“…Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the…”
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Design of multi-scale protein complexes by hierarchical building block fusion by Hsia, Yang, Mout, Rubul, Sheffler, William, Edman, Natasha I., Vulovic, Ivan, Park, Young-Jun, Redler, Rachel L., Bick, Matthew J., Bera, Asim K., Courbet, Alexis, Kang, Alex, Brunette, T. J., Nattermann, Una, Tsai, Evelyn, Saleem, Ayesha, Chow, Cameron M., Ekiert, Damian, Bhabha, Gira, Veesler, David, Baker, David

“…A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing…”
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Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis by Fichtner, Miriam L, Vieni, Casey, Redler, Rachel L, Kolich, Ljuvica, Jiang, Ruoyi, Takata, Kazushiro, Stathopoulos, Panos, Suarez, Pablo A, Nowak, Richard J, Burden, Steven J, Ekiert, Damian C, O'Connor, Kevin C

“…Pathogenic muscle-specific tyrosine kinase (MuSK)-specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of…”
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Glutathionylation at Cys-111 Induces Dissociation of Wild Type and FALS Mutant SOD1 Dimers by Redler, Rachel L, Wilcox, Kyle C, Proctor, Elizabeth A, Fee, Lanette, Caplow, Michael, Dokholyan, Nikolay V

“…Mutation of the ubiquitous cytosolic enzyme Cu/Zn superoxide dismutase (SOD1) is hypothesized to cause familial amyotrophic lateral sclerosis (FALS) through…”
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Computational approaches to understanding protein aggregation in neurodegeneration by Redler, Rachel L., Shirvanyants, David, Dagliyan, Onur, Ding, Feng, Kim, Doo Nam, Kota, Pradeep, Proctor, Elizabeth A., Ramachandran, Srinivas, Tandon, Arpit, Dokholyan, Nikolay V.

“…The generation of toxic non-native protein conformers has emerged as a unifying thread among disorders such as Alzheimer＇s disease, Parkinson＇s disease, and…”
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Elucidating the role of a trans-envelope MCE transport system in Pseudomonas aeruginosa by Giacometti, Sabrina I., Redler, Rachel L., Mody, Krishna, Ekiert, Damian C., Bhabha, Gira

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Protein Destabilization as a Common Factor in Diverse Inherited Disorders by Redler, Rachel L., Das, Jhuma, Diaz, Juan R., Dokholyan, Nikolay V.

“…Protein destabilization by amino acid substitutions is proposed to play a prominent role in widespread inherited human disorders, not just those known to…”
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Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity by Tsao, Douglas, Wieskopf, Jeffrey S., Rashid, Naim, Sorge, Robert E., Redler, Rachel L., Segall, Samantha K., Mogil, Jeffrey S., Maixner, William, Dokholyan, Nikolay V., Diatchenko, Luda

“…The subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different…”
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Cu,Zn-Superoxide Dismutase without Zn Is Folded but Catalytically Inactive by Nedd, Sean, Redler, Rachel L., Proctor, Elizabeth A., Dokholyan, Nikolay V., Alexandrova, Anastassia N.

“…Amyotrophic lateral sclerosis has been linked to the gain of aberrant function of superoxide dismutase, Cu,Zn-SOD1 upon protein misfolding. The mechanism of…”
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The Complex Molecular Biology of Amyotrophic Lateral Sclerosis (ALS) by Redler, Rachel L., Dokholyan, Nikolay V.

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that causes selective death of motor neurons followed by paralysis and death…”
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Non-native Soluble Oligomers of Cu/Zn Superoxide Dismutase (SOD1) Contain a Conformational Epitope Linked to Cytotoxicity in Amyotrophic Lateral Sclerosis (ALS) by Redler, Rachel L, Fee, Lanette, Fay, James M, Caplow, Michael, Dokholyan, Nikolay V

“…Soluble misfolded Cu/Zn superoxide dismutase (SOD1) is implicated in motor neuron death in amyotrophic lateral sclerosis (ALS); however, the relative…”
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De novo design of proteins housing excitonically coupled chlorophyll special pairs by Ennist, Nathan M., Wang, Shunzhi, Kennedy, Madison A., Curti, Mariano, Sutherland, George A., Vasilev, Cvetelin, Redler, Rachel L., Maffeis, Valentin, Shareef, Saeed, Sica, Anthony V., Hua, Ash Sueh, Deshmukh, Arundhati P., Moyer, Adam P., Hicks, Derrick R., Swartz, Avi Z., Cacho, Ralph A., Novy, Nathan, Bera, Asim K., Kang, Alex, Sankaran, Banumathi, Johnson, Matthew P., Phadkule, Amala, Reppert, Mike, Ekiert, Damian, Bhabha, Gira, Stewart, Lance, Caram, Justin R., Stoddard, Barry L., Romero, Elisabet, Hunter, C. Neil, Baker, David

“…Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecules that accepts excitation energy from the…”
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Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis by Wilcox, Kyle C, Zhou, Li, Jordon, Joshua K, Huang, Yi, Yu, Yanbao, Redler, Rachel L, Chen, Xian, Caplow, Michael, Dokholyan, Nikolay V

“…Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1…”
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Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes by Wilcox, Kyle C., Zhou, Li, Jordon, Joshua K., Huang, Yi, Yu, Yanbao, Redler, Rachel L., Chen, Xian, Caplow, Michael, Dokholyan, Nikolay V.

“…Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1…”
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Monovalent IgG4 autoantibodies require self-antigen driven affinity maturation to acquire pathogenic capacity by Fichtner, Miriam F L, Vieni, Casey, Redler, Rachel L., Jiang, Ruoyi, Suarez, Pablo, Nowak, Richard, Burden, Steven J, Bhabha, Gira, Ekiert, Damian C, O’Connor, Kevin C

“…Abstract INTRODUCTION The mechanisms underlying B cell-mediated autoimmune disease and the origin of autoreactive B cells are not well understood. Human…”
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Post-Translational Modifications Promote Formation of SOD1 Oligomers with Potential Toxicity in ALS by Dokholyan, Nikolay V., Redler, Rachel L., Proctor, Elizabeth A., Ding, Feng V., Wilcox, Kyle, Caplow, Michael

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The impact of post-translational modifications on aggregation of Cu, Zn superoxide dismutase in amyotrophic lateral sclerosis by Redler, Rachel L

“…Aberrant conformers of disease-linked proteins have been proposed as cytotoxic agents in several late-onset neurodegenerative disorders, including Alzheimer's…”
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