Search Results - "Redka, Dar'ya S."

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease by Sugiyama, Michael G., Cui, Haotian, Redka, Dar’ya S., Karimzadeh, Mehran, Rujas, Edurne, Maan, Hassaan, Hayat, Sikander, Cheung, Kyle, Misra, Rahul, McPhee, Joseph B., Viirre, Russell D., Haller, Andrew, Botelho, Roberto J., Karshafian, Raffi, Sabatinos, Sarah A., Fairn, Gregory D., Madani Tonekaboni, Seyed Ali, Windemuth, Andreas, Julien, Jean-Philippe, Shahani, Vijay, MacKinnon, Stephen S., Wang, Bo, Antonescu, Costin N.

“…The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by…”
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Allosteric modulation in monomers and oligomers of a G protein-coupled receptor by Shivnaraine, Rabindra V, Kelly, Brendan, Sankar, Krishana S, Redka, Dar'ya S, Han, Yi Rang, Huang, Fei, Elmslie, Gwendolynne, Pinto, Daniel, Li, Yuchong, Rocheleau, Jonathan V, Gradinaru, Claudiu C, Ellis, John, Wells, James W

“…The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown…”
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Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis by Redka, Dar'ya S, Gütschow, Michael, Grinstein, Sergio, Canton, Johnathan

“…Macropinocytosis mediates the uptake of antigens and of nutrients that dictate the regulation of cell growth by mechanistic target of rapamycin complex 1…”
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Coupling of G Proteins to Reconstituted Monomers and Tetramers of the M2 Muscarinic Receptor by Redka, Dar'ya S., Morizumi, Takefumi, Elmslie, Gwendolynne, Paranthaman, Pranavan, Shivnaraine, Rabindra V., Ellis, John, Ernst, Oliver P., Wells, James W.

“…G protein-coupled receptors can be reconstituted as monomers in nanodiscs and as tetramers in liposomes. When reconstituted with G proteins, both forms enable…”
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Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptor by Redka, Dar'ya S, Pisterzi, Luca F, Wells, James W

“…The M(2) muscarinic receptor has two topographically distinct sites: the orthosteric site and an allosteric site recognized by compounds such as gallamine. It…”
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Recovery of Oligomers and Cooperativity When Monomers of the M2 Muscarinic Cholinergic Receptor Are Reconstituted into Phospholipid Vesicles by Ma, Amy W.-S, Redka, Dar'ya S, Pisterzi, Luca F, Angers, Stéphane, Wells, James W

“…FLAG- and HA-tagged M2 muscarinic receptors from coinfected Sf9 cells have been purified in digitonin−cholate and reconstituted into phospholipid vesicles. The…”
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Efficacy as an Intrinsic Property of the M 2 Muscarinic Receptor in Its Tetrameric State by Redka, Dar’ya S., Heerklotz, Heiko, Wells, James W.

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Efficacy as an Intrinsic Property of the M2 Muscarinic Receptor in Its Tetrameric State by Redka, Dar’ya S, Heerklotz, Heiko, Wells, James W

“…Muscarinic and other G protein-coupled receptors exhibit an agonist-specific heterogeneity that tracks efficacy and commonly is attributed to an effect of the…”
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Interaction of Digitonin and Cholate with Complex Membranes by Fan, Helen Y., Redka, Dar'ya S., Heerklotz, Heiko

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Functional Comparison of Monomers and Tetramers of the M2 Muscarinic Receptor by Redka, Dar'ya S., Morizumi, Takefumi, Paranthaman, Pranavan, Heerklotz, Heiko, Ernst, Oliver P., Wells, James W.

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Cooperativity in the Binding of Agonists to Reconstituted Tetramers of the M2 Muscarinic Receptor by Redka, Dar'ya S., Heerklotz, Heiko, Wells, James W.

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Cooperativity in the Binding of Agonists to Reconstituted Tetramers of the M 2 Muscarinic Receptor by Redka, Dar'ya S., Heerklotz, Heiko, Wells, James W.

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Efficacy As An Intrinsic Property of the M2 Muscarinic Receptor in Its Oligomeric State by Redka, Dar'ya S., Heerklotz, Heiko, Wells, James W.

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Recovery of Oligomers and Cooperativity When Monomers of the M 2 Muscarinic Cholinergic Receptor Are Reconstituted into Phospholipid Vesicles by Ma, Amy W.-S., Redka, Dar'ya S., Pisterzi, Luca F., Angers, Stéphane, Wells, James W.

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Efficacy as an intrinsic property of the M(2) muscarinic receptor in its tetrameric state by Redka, Dar'ya S, Heerklotz, Heiko, Wells, James W

“…Muscarinic and other G protein-coupled receptors exhibit an agonist-specific heterogeneity that tracks efficacy and commonly is attributed to an effect of the…”
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Biophysical Analysis of a Successful Protocol to Reconstitute Tetramers of the M2 Muscarinic Receptor by Fan, Helen Y., Redka, Dar’ya S., Heerklotz, Heiko

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Differences in the Allosteric Interaction between Agonists and GMP-PNP in Monomers and Oligomers of the M2 Muscarinic Cholinergic Receptor Fused to GαI1 by Dong, John Y., Huang, Fei, Ma, Amy W.-S., Redka, Dar’ya S., Wells, James W.

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