Search Results - "Reding, Esther"

Monitoring interactions between receptor tyrosine kinases and their downstream effector proteins in living cells using bioluminescence resonance energy transfer by Tan, Philip K, Wang, Jean, Littler, Pey-Lih H, Wong, Kenneth K, Sweetnam, Timothy A, Keefe, William, Nash, Norman R, Reding, Esther C, Piu, Fabrice, Brann, Mark R, Schiffer, Hans H

“…A limited number of whole-cell assays allow monitoring of receptor tyrosine kinase (RTK) activity in a signaling pathway-specific manner. We present the…”
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Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer by Schiffer, Hans H, Reding, Esther C, Fuhs, Stephen R, Lu, Qing, Piu, Fabrice, Wong, Steven, Littler, Pey-Lih H, Weiner, Dave M, Keefe, William, Tan, Phil K, Nash, Norman R, Knapp, Anne E, Olsson, Roger, Brann, Mark R

“…We have developed a new assay for measuring epidermal growth factor receptor (EGFR) activation using the bioluminescence resonance energy transfer (BRET)…”
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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists by Azimioara, Mihai, Alper, Phil, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mecom, John, McNeill, Matthew, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessl, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert

“…[Display omitted] Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays…”
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Discovery of structurally novel, potent and orally efficacious GPR119 agonists by Alper, Phil, Azimioara, Mihai, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessel, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert

“…Screening hit 5 was identified in a biochemical screen for GPR119 agonists. Compound 5 was structurally novel, displayed modest biochemical activity and no…”
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