Search Results - "Redinbo, Matthew R."

The role of the microbiome in cancer development and therapy by Bhatt, Aadra P., Redinbo, Matthew R., Bultman, Scott J.

“…Answer questions and earn CME/CNE The human body harbors enormous numbers of microbiota that influence cancer susceptibility, in part through their prodigious…”
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Glucuronides in the gut: Sugar-driven symbioses between microbe and host by Pellock, Samuel J., Redinbo, Matthew R.

“…The intestinal milieu is astonishingly complex and home to a constantly changing mixture of small and large molecules, along with an abundance of bacteria,…”
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Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 by Venkatesh, Madhukumar, Mukherjee, Subhajit, Wang, Hongwei, Li, Hao, Sun, Katherine, Benechet, Alexandre P., Qiu, Zhijuan, Maher, Leigh, Redinbo, Matthew R., Phillips, Robert S., Fleet, James C., Kortagere, Sandhya, Mukherjee, Paromita, Fasano, Alessio, Le Ven, Jessica, Nicholson, Jeremy K., Dumas, Marc E., Khanna, Kamal M., Mani, Sridhar

“…Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed that…”
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Gut-Derived Protein-Bound Uremic Toxins by Graboski, Amanda L, Redinbo, Matthew R

“…Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular…”
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Plant "helper" immune receptors are Ca2+-permeable nonselective cation channels by Jacob, Pierre, Kim, Nak Hyun, Wu, Feihua, El-Kasmi, Farid, Chi, Yuan, Walton, William G, Furzer, Oliver J, Lietzan, Adam D, Sunil, Sruthi, Kempthorn, Korina, Redinbo, Matthew R, Pei, Zhen-Ming, Wan, Li, Dangl, Jeffery L

“…Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In Arabidopsis, a subfamily of "helper" NLRs is required by…”
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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme by Wallace, Bret D, Wang, Hongwei, Lane, Kimberly T, Scott, John E, Orans, Jillian, Koo, Ja Seol, Venkatesh, Madhukumar, Jobin, Christian, Yeh, Li-An, Mani, Sridhar, Redinbo, Matthew R

“…The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that…”
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Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies by Boelsterli, Urs A, Redinbo, Matthew R, Saitta, Kyle S

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause serious gastrointestinal (GI) injury including jejunal/ileal mucosal ulceration, bleeding, and even…”
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Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis by Ortlund, Eric A, Bridgham, Jamie T, Redinbo, Matthew R, Thornton, Joseph W

“…The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral…”
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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways by Garland, Alaina L., Walton, William G., Coakley, Raymond D., Tan, Chong D., Gilmore, Rodney C., Hobbs, Carey A., Tripathy, Ashutosh, Clunes, Lucy A., Bencharit, Sompop, Stutts, M. Jackson, Betts, Laurie, Redinbo, Matthew R., Tarran, Robert

“…The ability to maintain proper airway surface liquid (ASL) volume homeostasis is vital for mucus hydration and clearance, which are essential aspects of the…”
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Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response by Simpson, Joshua B., Sekela, Josh J., Carry, Benjamin S., Beaty, Violet, Patel, Shakshi, Redinbo, Matthew. R.

“…Prodrugs reliant on microbial activation are widely used but exhibit a range of efficacies that remain poorly understood. The anti-inflammatory compound…”
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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate by Simpson, Joshua B., Sekela, Josh J., Graboski, Amanda L., Borlandelli, Valentina B., Bivins, Marissa M., Barker, Natalie K., Sorgen, Alicia A., Mordant, Angie L., Johnson, Rebecca L., Bhatt, Aadra P., Fodor, Anthony A., Herring, Laura E., Overkleeft, Hermen, Lee, John R., Redinbo, Matthew. R.

“…Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF…”
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Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective by Wallace, Bret D., Redinbo, Matthew R.

“…Xenobiotic compounds undergo a critical range of biotransformations performed by the phase I, II, and III drug-metabolizing enzymes. The oxidation,…”
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Understanding and modulating mammalian-microbial communication for improved human health by Mani, Sridhar, Boelsterli, Urs A, Redinbo, Matthew R

“…The fact that the bacteria in the human gastrointestinal (GI) tract play a symbiotic role was noted as early as 1885, well before we began to manage microbial…”
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Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus by Yu, Zhongjie, Deslouches, Berthony, Walton, William G, Redinbo, Matthew R, Di, Y Peter

“…SPLUNC1 is a multifunctional protein of the airway with antimicrobial properties. We previously reported that it displayed antibiofilm activities against P…”
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Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR by Ekins, Sean, Kortagere, Sandhya, Iyer, Manisha, Reschly, Erica J, Lill, Markus A, Redinbo, Matthew R, Krasowski, Matthew D

“…Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn…”
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Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice by Letertre, Marine P. M., Bhatt, Aadra P., Harvey, Michael, Nicholson, Jeremy K., Wilson, Ian D., Redinbo, Matthew R., Swann, Jonathan R.

“…The hydrolysis of xenobiotic glucuronides by gut bacterial glucuronidases reactivates previously detoxified compounds resulting in severe gut toxicity for the…”
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unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa by Marden, Jeremiah N., Diaz, Manisha R., Walton, William G., Gode, Cindy J., Betts, Laurie, Urbanowski, Mark L., Redinbo, Matthew R., Yahr, Timothy L., Wolfgang, Matthew C.

“…Members of the CsrA family of prokaryotic mRNA-binding proteins alter the translation and/or stability of transcripts needed for numerous global physiological…”
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Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor by Wu, Tongde, Huang, Julianne, Moore, Patrick J., Little, Michael S., Walton, William G., Fellner, Robert C., Alexis, Neil E., Peter Di, Y., Redinbo, Matthew R., Tilley, Stephen L., Tarran, Robert

“…Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial…”
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Post-translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A by Ghodge, Swapnil V, Biernat, Kristen A, Bassett, Sarah Jane, Redinbo, Matthew R, Bowers, Albert A

“…Pantocin A (PA) is a member of the growing family of ribosomally encoded and post-translationally modified peptide natural products (RiPPs). PA is much smaller…”
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Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase‐targeted anti‐HIV drug PNU‐142721 by Cheng, Yuan, Redinbo, Matthew R.

“…The human pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand‐regulated transcription factors. PXR responds to a structurally…”
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