Search Results - "Redfern, C. H."

Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer by Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., Bridgewater, J., Moore, M., Cassidy, J., Coleman, R., Coxon, F., Redfern, C. H., Jones, J. J., Hawkins, R., Northfelt, D., Sreedharan, S., Valone, F., Carmichael, J.

“…Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the…”
Get full text

In vivo-Like Drug Responses of Human Tumors Growing in Three-Dimensional Gel-Supported Primary Culture by Vescio, Robert A., Redfern, Charles H., Nelson, Theodora J., Ugoretz, Scott, Stern, Peter H., Hoffman, Robert M.

“…An in vitro test of cell sensitivity to drugs that indicates in vivo response is an important need in cancer therapy and cancer drug development. Toward this…”
Get full text

Engineering receptors activated solely by synthetic ligands (RASSLs) by Scearce-Levie, Kimberly, Coward, Peter, Redfern, Charles H., Conklin, Bruce R.

“…The functional and molecular diversity of G-protein-coupled receptors presents a significant challenge to understanding the connection between a single…”
Get full text

Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy by Baker, A J, Redfern, C H, Harwood, M D, Simpson, P C, Conklin, B R

“…Although increased G(i) signaling has been associated with dilated cardiomyopathy in humans, its role is not clear. Our goal was to determine the effects of…”
Get more information

Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands by Scearce-Levie, Kimberly, Coward, Peter, Redfern, Charles H, Conklin, Bruce R

Get more information

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice by REDFERN, C. H, COWARD, P, DEGTYAREV, M. Y, LEE, E. K, KWA, A. T, HENNIGHAUSEN, L, BUJARD, H, FISHMAN, G. I, CONKLIN, B. R

“…To control G protein signaling in vivo, we have modified G protein-coupled receptors to respond exclusively to synthetic small molecule agonists and not to…”
Get full text

Predictors of outcome and subgroup results from the integrated analysis of sipuleucel-T trials in metastatic castration-resistant prostate cancer by Higano, C. S., Small, E. J., Schellhammer, P. F., Kantoff, P., Redfern, C. H., Nemunaitis, J. J., Nabhan, C., Xu, Y., Whitmore, J. B., Frohlich, M. W.

“…Abstract only…”
Get full text

GCS-100, a galectin-3 antagonist, in refractory solid tumors: A phase I study by Grous, J. J., Redfern, C. H., Mahadevan, D., Schindler, J.

“…Abstract only 13023 Background: Galectin-3 is a galactoside-binding protein implicated in inhibition of apoptosis, and promotion of angiogenesis, metastasis,…”
Get full text

Conditional Expression of a Gi-Coupled Receptor Causes Ventricular Conduction Delay and a Lethal Cardiomyopathy by Redfern, Charles H., Degtyarev, Michael Y., Kwa, Andrew T., Salomonis, Nathan, Cotte, Nathalie, Nanevicz, Tania, Fidelman, Nick, Desai, Kavin, Vranizan, Karen, Lee, Elena K., Coward, Peter, Shah, Nila, Warrington, Janet A., Fishman, Glenn I., Bernstein, Daniel, Baker, Anthony J., Conklin, Bruce R.

“…Cardiomyopathy is a major cause of morbidity and mortality. Ventricular conduction delay, as shown by prolonged deflections in the electrocardiogram caused by…”
Get full text

Abstract PD3-07: Safety and efficacy results from a phase 1 study of DS-8201a in patients with HER2 expressing breast cancers by Modi, S, Tsurutani, J, Takahashi, S, Iwata, H, Park, H, Redfern, CH, Doi, T, Li, B, Iwasa, T, Taira, S, Hattori, M, Ma, CX, Fisher, JM, Naito, Y, Yonemori, K, Kawasaki, Y, Saito, K, Jikoh, T, Shahidi, J, Lee, CC, Yver, A, Tamura, K

“…Abstract Background DS-8201a is a HER2 targeting antibody-drug conjugate (ADC) with high drug to antibody ratio (8:1), a novel linker and topoisomerase I…”
Get full text

Conditional expression of a G sub(i)- coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy by Redfern, CH, Degtyarev, MY, Kwa, A T, Salomonis, N, Cotte, N, Nanevicz, T, Fidelman, N, Desai, K, Vranizan, K, Lee, E K, Coward, P, Shah, N, Warrington, JA, Fishman, GI, Bernstein, D

“…Cardiomyopathy is a major cause of morbidity and mortality. Ventricular conduction delay, as shown by prolonged deflections in the electrocardiogram caused by…”
Get full text

Conditional expression and signaling of a specifically designed G sub(i)-coupled receptor in transgenic mice by Redfern, CH, Coward, P, Degtyarev, MY, Lee, E K, Kwa, A T, Hennighausen, L, Bujard, H, Fishman, GI, Conklin, B R

“…To control G protein signaling in vivo, we have modified G protein-coupled receptors to respond exclusively to synthetic small molecule agonists and not to…”
Get full text