An Efficient Green Multi-Component Reaction Strategy for the Synthesis of Highly Functionalised Pyridines and Evaluation of Their Antibacterial Activities

An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3,5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO3 under solvent fr...

Full description

Saved in:

Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 61; no. 11; pp. 1114 - 1120
Main Authors:	Reddy, Lakkireddy Srinivasula, Reddy, Tirumalareddy Ram, Mohan, Reddy Bodireddy, Mahesh, Avula, Lingappa, Yeramanchi, Reddy, Nallagondu Chinna Gangi
Format:	Journal Article
Language:	English
Published:	Japan The Pharmaceutical Society of Japan 01-11-2013 Japan Science and Technology Agency
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial activity Carbonates - chemistry Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects green chemistry Green Chemistry Technology grindstone chemistry Microbial Sensitivity Tests multi-component reaction Potassium - chemistry pyridine Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology solvent-free synthesis Solvents - chemistry
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3,5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c13-00412