Search Results - "Reddy, Shrikanth A"

Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies by Javle, Milind M, Shroff, Rachna T, Xiong, Henry, Varadhachary, Gauri A, Fogelman, David, Reddy, Shrikanth A, Davis, Darren, Zhang, Yujian, Wolff, Robert A, Abbruzzese, James L

“…The phosphoinositide 3-kinase (PI3K)/Akt pathway is constitutively activated in pancreatic cancer and the mammalian target of rapamycin (mTOR) kinase is an…”
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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells by ASANO, Takayuki, YIXIN YAO, JIJIANG ZHU, DONGHUI LI, ABBRUZZESE, James L, REDDY, Shrikanth A. G

“…The persistent activation of signaling cascades results in dramatic consequences that include loss of cellular growth control and neoplastic transformation. We…”
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PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway by Koul, Dimpy, Shen, Ruijun, Shishodia, Shishir, Takada, Yasanuri, Bhat, Krishna P, Reddy, Shrikanth A. G, Aggarwal, Bharat B, Yung, W. K. Alfred

“…The continual activation of signaling cascades results in dramatic consequences that include loss of cellular growth control and neoplastic transformation. We…”
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The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation by Asano, Takayuki, Yao, Yixin, Zhu, Jijiang, Li, Donghui, Abbruzzese, James L., Reddy, Shrikanth A.

“…We present immunohistochemical evidence that the mTOR/p70s6k pathway is activated in pancreatic tumors and show that the mTOR inhibitor and rapamycin analog…”
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Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells by ASANO, Takayuki, YIXIN YAO, SHIN, Sonyo, MCCUBREY, James, ABBRUZZESE, James L, REDDY, Shrikanth A. G

“…Phosphoinositide 3-kinase (PI3K) is activated in pancreatic cancer cells and plays a central role in their proliferation, survival, and drug resistance…”
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Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway by Shin-Kang, Sonyo, Ramsauer, Victoria P., Lightner, Janet, Chakraborty, Kanishka, Stone, William, Campbell, Sharon, Reddy, Shrikanth A.G., Krishnan, Koyamangalath

“…Tocotrienols are members of the vitamin E family but, unlike tocopherols, possess an unsaturated isoprenoid side chain that confers superior anti-cancer…”
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Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a by Suzuki, Seigo, Naito, Akihiro, Asano, Takayuki, Evans, Teresa T, Reddy, Shrikanth A.G, Higuchi, Masahiro

“…Abstract TNF plus protein synthesis inhibitor cycloheximide-induced apoptosis in human myelogenous leukemia ML-1a but not in C19, respiration minus…”
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BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation by Yao, Yixin, Suraokar, Milind, Darnay, Bryant G, Hollier, Brett G, Shaiken, Tattym E, Asano, Takayuki, Chen, Chien-Hung, Chang, Benny H-J, Lu, Yiling, Mills, Gordon B, Sarbassov, Dos, Mani, Sendurai A, Abbruzzese, James L, Reddy, Shrikanth A G

“…Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. However, neither the complex multistep process that leads to…”
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536 Oncogenic Ki-RAS-miR-21 Signaling Promotes AKT Activation in Pancreatic Cancer Cells Through a Novel AKT-Interacting Protein Bsta by Yao, Yixin, Canizales, Martin, Ramachandran, Vijaya, Arumugam, Thiruvengadam, Logsdon, Craig D, Abbruzzese, James, Guha, Sushovan, Reddy, Shrikanth A

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Biological Role of and Targeting Oncogenic Ki-RAS Induced a Novel AKT Regulator in Pancreatic Cancer by Yao, Yixin, Tong, Zhimin, Reddy, Shrikanth A, Guha, Sushovan

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Establishment of three-dimensional cultures of human pancreatic duct epithelial cells by Gutierrez-Barrera, Angelica M., Menter, David G., Abbruzzese, James L., Reddy, Shrikanth A.G.

“…Three-dimensional (3D) cultures of epithelial cells offer singular advantages for studies of morphogenesis or the role of cancer genes in oncogenesis. In this…”
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Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism by Shin, Sonyo, Asano, Takayuki, Yao, Yixin, Zhang, Ronghua, Claret, Francois-Xavier, Korc, Murray, Sabapathy, Kanaga, Menter, David G, Abbruzzese, James L, Reddy, Shrikanth A G

“…Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis. However, there is little known about this transcription…”
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Resistance of Human Ovarian Cancer Cells to Tumor Necrosis Factor α Is a Consequence of Nuclear Factor κB-Mediated Induction of Fas-Associated Death Domain-Like Interleukin-1β-Converting Enzyme-Like Inhibitory Protein by Xiao, Chao Wu, Yan, Xiaojuan, Li, Yulian, Reddy, Shrikanth A. G, Tsang, Benjamin K

“…The purpose of the present studies was to examine the role and regulation of Fas-associated death domain-like IL-1- converting enzyme-like inhibitory protein…”
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Hypothesis generation in signaling networks by Ruths, Derek A, Nakhleh, Luay, Iyengar, M Sriram, Reddy, Shrikanth A G, Ram, Prahlad T

“…Biological signaling networks comprise the chemical processes by which cells detect and respond to changes in their environment. Such networks have been…”
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Erratum: The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells by Asano, Takayuki, Yao, Yixin, Zhu, Jijiang, Li, Donghui, Abbruzzese, James L, Reddy, Shrikanth AG

“…Correction to: Oncogene (2004) 23, 8571–8580. doi:10.1038/sj.onc.1207902 Due to a typesetting error, Figure 6c of this paper contained an incorrect legend. The…”
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Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-kappa B activation by Reddy, S A, Huang, J H, Liao, W S

“…The activation of transcription factor NF-kappa B by TNF involves the stimulation of a novel signaling cascade. In this paper we show that phosphatidylinositol…”
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Alleviating the Suppression of Glycogen Synthase Kinase-3β by Akt Leads to the Phosphorylation of cAMP-response Element-binding Protein and Its Transactivation in Intact Cell Nuclei by Salas, Thomas R., Reddy, Shrikanth A., Clifford, John L., Davis, Roger J., Kikuchi, Akira, Lippman, Scott M., Menter, David G.

“…Glycogen synthase kinase-3β (GSK-3β) activity is suppressed when it becomes phosphorylated on serine 9 by protein kinase B (Akt). To determine how GSK-3β…”
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Inhibition of the mammalian target of rapamycin by Javle, Milind M, Varadhachary, Gauri A, Xiong, Henry, Shroff, Rachna T, Zhang, Yujian, Wolff, Robert A, Davis, Darren, Reddy, Shrikanth A, Fogelman, David, Abbruzzese, James L

“…Background The phosphoinositide 3-kinase (PI3K)/Akt pathway is constitutively activated in pancreatic cancer and the mammalian target of rapamycin (mTOR)…”
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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells by Asano, Takayuki, Yao, Yixin, Zhu, Jijiang, Li, Donghui, Abbruzzese, James L, Reddy, Shrikanth A G

“…The persistent activation of signaling cascades results in dramatic consequences that include loss of cellular growth control and neoplastic transformation. We…”
Get full text

The PI 3-kinase Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF- B and c-Myc in pancreatic cancer cells by Asano, Takayuki, Yao, Yixin, Zhu, Jijiang, Li, Donghui, Abbruzzese, James L, Reddy, Shrikanth A G

“…The persistent activation of signaling cascades results in dramatic consequences that include loss of cellular growth control and neoplastic transformation. We…”
Get full text