Search Results - "Reddy, Raju C"

PPAR Agonists for the Prevention and Treatment of Lung Cancer by Reddy, Raju C., Banno, Asoka, Reddy, Aravind T., Lakshmi, Sowmya P.

“…Lung cancer is the most common and most fatal of all malignancies worldwide. Furthermore, with more than half of all lung cancer patients presenting with…”
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Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD) by Reddy, Aravind T, Lakshmi, Sowmya P, Banno, Asoka, Jadhav, Shantanu Krishna, Pulikkal Kadamberi, Ishaque, Kim, Seong C, Reddy, Raju C

“…Cigarette smoke (CS) contains multiple gaseous and particulate materials that can cause lung inflammation, and smoking is the major cause of chronic…”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Reddy, Aravind T., Reddy, Raju C., Lakshmi, Sowmya P.

“…Lung cancer is the leading cause of cancer-related death, with more than half the patients having advanced-stage disease at the time of initial diagnosis and…”
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Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases by Banno, Asoka, Lakshmi, Sowmya P., Reddy, Aravind T., Kim, Seong C., Reddy, Raju C.

“…The transcription factor Nur77 belongs to the NR4A subfamily of nuclear hormone receptors. It features an atypical ligand-binding site that precludes canonical…”
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Immunomodulatory Role of PPAR-γ in Alveolar Macrophages by Reddy, Raju C.

“…The lung is constantly exposed to inhaled pathogens and toxins yet totally dependent on the integrity of a delicate alveolar-capillary interface for its…”
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Changes in weather and the effects on pediatric asthma exacerbations by Mireku, Nana, MD, Wang, Yun, MS, Ager, Joel, PhD, Reddy, Raju C., MD, Baptist, Alan P., MD, MPH

“…Background Pediatric asthma exacerbations may correlate with changes in weather, yet this relationship is not well defined. Objective To determine the effects…”
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Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro by Gandapu, Upendhar, Chaitanya, R K, Kishore, Golla, Reddy, Raju C, Kondapi, Anand K

“…Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because of its low…”
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Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation by Reddy, Aravind T, Lakshmi, Sowmya P, Muchumarri, Ramamohan R, Reddy, Raju C

“…Nitrated fatty acids (NFAs), endogenous products of nonenzymatic reactions of NO-derived reactive nitrogen species with unsaturated fatty acids, exhibit…”
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Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury by Smith, Monica R, Gangireddy, Srinivasa R, Narala, Venkata R, Hogaboam, Cory M, Standiford, Theodore J, Christensen, Paul J, Kondapi, Anand K, Reddy, Raju C

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and typically fatal lung disease for which no effective therapy has been identified. The disease is…”
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Differential Protein Expression Profiling by iTRAQ−2DLC−MS/MS of Lung Cancer Cells Undergoing Epithelial-Mesenchymal Transition Reveals a Migratory/Invasive Phenotype by Keshamouni, Venkateshwar G, Michailidis, George, Grasso, Catherine S, Anthwal, Shalini, Strahler, John R, Walker, Angela, Arenberg, Douglas A, Reddy, Raju C, Akulapalli, Sudhakar, Thannickal, Victor J, Standiford, Theodore J, Andrews, Philip C, Omenn, Gilbert S

“…Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) of epithelial cells in both normal embryonic development and certain…”
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Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI by Lakshmi, Sowmya P, Reddy, Aravind T, Naik, Meghna U, Naik, Ulhas P, Reddy, Raju C

“…Transmigration of neutrophils (PMNs) from the vasculature into inflamed tissues, mediated by interactions between PMNs and adhesion molecules on endothelial…”
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PPARγ in Bacterial Infections: A Friend or Foe? by Reddy, Aravind T., Reddy, Raju C., Lakshmi, Sowmya P.

“…Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of leukocyte inflammatory responses and function. Its…”
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Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress by Reddy, Aravind T., Lakshmi, Sowmya P., Banno, Asoka, Reddy, Raju C.

“…Cigarette smoke, a source of numerous oxidants, produces oxidative stress and exaggerated inflammatory responses that lead to irreversible lung tissue damage…”
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The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice by Reddy, Aravind T., Lakshmi, Sowmya P., Reddy, Raju C.

“…Acute lung injury (ALI) is an inflammatory condition culminating in respiratory failure. There is currently no effective pharmacological treatment. Nitrated…”
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Comprehensive characterization of a novel small-molecule activator for the nuclear receptor Nur77: Chemical, molecular, and biological insights by Reddy, Aravind T., Lakshmi, Sowmya P., Nyunoya, Toru, Reddy, Raju C.

“…The nuclear receptor Nur77 is a transcription factor belonging to the NR4A subfamily. Upon activation, it regulates a wide array of biological and…”
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PPAR-γ Activation Inhibits Angiogenesis by Blocking ELR+CXC Chemokine Production in Non-small Cell Lung Cancer by Keshamouni, Venkateshwar G., Arenberg, Douglas A., Reddy, Raju C., Newstead, Michael J., Anthwal, Shalini, Standiford, Theodore J.

“…Activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) results in inhibition of tumor growth in various types of cancers, but the mechanism(s) by…”
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Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non–Small Cell Lung Cancer by Reddy, Raju C., Srirangam, Anjaiah, Reddy, Kaunteya, Chen, Jun, Gangireddy, Srinivasareddy, Kalemkerian, Gregory P., Standiford, Theodore J., Keshamouni, Venkateshwar G.

“…Preclinical studies have shown that peroxisome proliferator–activated receptor γ (PPAR-γ) ligands can exert antitumor effects against non–small cell lung…”
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Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease by Lakshmi, Sowmya P, Reddy, Aravind T, Banno, Asoka, Reddy, Raju C

“…Airway epithelial cells (AECs) orchestrate inflammatory responses to airborne irritants that enter the respiratory system. A viscous mucus layer produced by…”
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Pediatric Dyspnea Scale for use in hospitalized patients with asthma by Khan, Farah I., MD, Reddy, Raju C., MD, Baptist, Alan P., MD, MPH

“…Background Asthma is a leading cause of pediatric hospitalizations across the country, yet no clinical instrument exists that incorporates the child's…”
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Transforming growth factor β suppresses peroxisome proliferator-activated receptor γ expression via both SMAD binding and novel TGF-β inhibitory elements by Lakshmi, Sowmya P, Reddy, Aravind T, Reddy, Raju C

“…Transforming growth factor β (TGF-β) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-β and the anti-fibrotic nuclear hormone…”
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