Search Results - "Reddy, Iswarya"

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors by Mfuh, Adelphe M., Boerth, Jeffrey A., Bommakanti, Gayathri, Chan, Christina, Chinn, Alex J., Code, Erin, Fricke, Patrick J., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine, Hariparsad, Niresh, Hughes, Samantha J., Jin, Meizhong, Kantae, Vasudev, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan, Moore, Rachel, Puri, Taranee, Quinn, Taylor R., Reddy, Iswarya, Robb, Graeme R., Robbins, Kevin J., Gancedo Rodrigo, Miguel, Schimpl, Marianne, Singh, Baljinder, Singh, Meha, Tang, Haoran, Thomson, Clare, Walsh, Jarrod J., Ware, Jamie, Watson, Iain D. G., Ye, Min-Wei, Wrigley, Gail L., Zhang, Andrew X., Zhang, Yun, Grimster, Neil P.

“…Casitas B-lymphoma proto-oncogene-b (Cbl-b), a member of the Cbl family of RING finger E3 ubiquitin ligases, has been demonstrated to play a central role in…”
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Discovery of a Novel Benzodiazepine Series of Cbl‑b Inhibitors for the Enhancement of Antitumor Immunity by Boerth, Jeffrey A., Chinn, Alex J., Schimpl, Marianne, Bommakanti, Gayathri, Chan, Christina, Code, Erin L., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine S., Jin, Meizhong, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan S., Larner, Carrie J. B., Mfuh, Adelphe M., Moore, Rachel K., Puri, Taranee, Quinn, Taylor R., Ye, Minwei, Robbins, Kevin J., Gancedo-Rodrigo, Miguel, Tang, Haoran, Walsh, Jarrod, Ware, Jamie, Wrigley, Gail L., Reddy, Iswarya Karapa, Zhang, Yun, Grimster, Neil P.

“…Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) is a RING finger E3 ligase that is responsible for repressing T-cell, natural killer (NK) cell, and B-cell…”
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Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay by Tay, Tristan, Bommakanti, Gayathri, Jaensch, Elizabeth, Gorthi, Aparna, Karapa Reddy, Iswarya, Hu, Yan, Zhang, Ruochi, Doshi, Aatman S., Tan, Sin Lih, Brucklacher-Waldert, Verena, Prickett, Laura, Kurasawa, James, Overstreet, Michael Glen, Criscione, Steven, Buenrostro, Jason Daniel, Mele, Deanna A.

“…In cancer, chronic antigen stimulation drives effector T cells to exhaustion, limiting the efficacy of T cell therapies. Recent studies have demonstrated that…”
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