Search Results - "Reddy, Aravind T"

PPAR Agonists for the Prevention and Treatment of Lung Cancer by Reddy, Raju C., Banno, Asoka, Reddy, Aravind T., Lakshmi, Sowmya P.

“…Lung cancer is the most common and most fatal of all malignancies worldwide. Furthermore, with more than half of all lung cancer patients presenting with…”
Get full text

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD) by Reddy, Aravind T, Lakshmi, Sowmya P, Banno, Asoka, Jadhav, Shantanu Krishna, Pulikkal Kadamberi, Ishaque, Kim, Seong C, Reddy, Raju C

“…Cigarette smoke (CS) contains multiple gaseous and particulate materials that can cause lung inflammation, and smoking is the major cause of chronic…”
Get full text

PPARγ as a Novel Therapeutic Target in Lung Cancer by Reddy, Aravind T., Reddy, Raju C., Lakshmi, Sowmya P.

“…Lung cancer is the leading cause of cancer-related death, with more than half the patients having advanced-stage disease at the time of initial diagnosis and…”
Get full text

Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases by Banno, Asoka, Lakshmi, Sowmya P., Reddy, Aravind T., Kim, Seong C., Reddy, Raju C.

“…The transcription factor Nur77 belongs to the NR4A subfamily of nuclear hormone receptors. It features an atypical ligand-binding site that precludes canonical…”
Get full text

Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation by Reddy, Aravind T, Lakshmi, Sowmya P, Muchumarri, Ramamohan R, Reddy, Raju C

“…Nitrated fatty acids (NFAs), endogenous products of nonenzymatic reactions of NO-derived reactive nitrogen species with unsaturated fatty acids, exhibit…”
Get full text

Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI by Lakshmi, Sowmya P, Reddy, Aravind T, Naik, Meghna U, Naik, Ulhas P, Reddy, Raju C

“…Transmigration of neutrophils (PMNs) from the vasculature into inflamed tissues, mediated by interactions between PMNs and adhesion molecules on endothelial…”
Get more information

PPARγ in Bacterial Infections: A Friend or Foe? by Reddy, Aravind T., Reddy, Raju C., Lakshmi, Sowmya P.

“…Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of leukocyte inflammatory responses and function. Its…”
Get full text

Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress by Reddy, Aravind T., Lakshmi, Sowmya P., Banno, Asoka, Reddy, Raju C.

“…Cigarette smoke, a source of numerous oxidants, produces oxidative stress and exaggerated inflammatory responses that lead to irreversible lung tissue damage…”
Get full text

The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice by Reddy, Aravind T., Lakshmi, Sowmya P., Reddy, Raju C.

“…Acute lung injury (ALI) is an inflammatory condition culminating in respiratory failure. There is currently no effective pharmacological treatment. Nitrated…”
Get full text

Comprehensive characterization of a novel small-molecule activator for the nuclear receptor Nur77: Chemical, molecular, and biological insights by Reddy, Aravind T., Lakshmi, Sowmya P., Nyunoya, Toru, Reddy, Raju C.

“…The nuclear receptor Nur77 is a transcription factor belonging to the NR4A subfamily. Upon activation, it regulates a wide array of biological and…”
Get full text

Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease by Lakshmi, Sowmya P, Reddy, Aravind T, Banno, Asoka, Reddy, Raju C

“…Airway epithelial cells (AECs) orchestrate inflammatory responses to airborne irritants that enter the respiratory system. A viscous mucus layer produced by…”
Get full text

Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells by Lakshmi, Sowmya P., Reddy, Aravind T., Kodidhela, Lakshmi Devi, Varadacharyulu, N.Ch

“…Cigarette smoke (CS), the major risk factor of chronic obstructive pulmonary disease (COPD), contains numerous free radicals that can cause oxidative stress…”
Get full text

Transforming growth factor β suppresses peroxisome proliferator-activated receptor γ expression via both SMAD binding and novel TGF-β inhibitory elements by Lakshmi, Sowmya P, Reddy, Aravind T, Reddy, Raju C

“…Transforming growth factor β (TGF-β) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-β and the anti-fibrotic nuclear hormone…”
Get more information

Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages by Reddy, Aravind T., Lakshmi, Sowmya P., Zhang, Yingze, Reddy, Raju C.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease, thought to be largely transforming growth factor β (TGFβ) driven, for which there is no…”
Get full text

The tea catechin epigallocatechin gallate inhibits NF-κB-mediated transcriptional activation by covalent modification by Lakshmi, Sowmya P., Reddy, Aravind T., Kodidhela, Lakshmi Devi, Varadacharyulu, N. Ch

“…Potential health benefits of consuming tea are thought to include anti-inflammatory actions of its constituent flavonoids including catechins, which are…”
Get full text

Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-κB by Reddy, Aravind T., Lakshmi, Sowmya P., Maruthi Prasad, E., Varadacharyulu, N.Ch, Kodidhela, Lakshmi Devi

“…The endothelium is a critical regulator of vascular homeostasis, controlling vascular tone and permeability as well as interactions of leukocytes and platelets…”
Get full text

Down-regulated Peroxisome Proliferator-activated Receptor γ (PPARγ) in Lung Epithelial Cells Promotes a PPARγ Agonist-reversible Proinflammatory Phenotype in Chronic Obstructive Pulmonary Disease (COPD) by Lakshmi, Sowmya P., Reddy, Aravind T., Zhang, Yingze, Sciurba, Frank C., Mallampalli, Rama K., Duncan, Steven R., Reddy, Raju C.

“…Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and a leading cause of death, with no available cure. We assessed the…”
Get full text

The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease by Reddy, Aravind T, Lakshmi, Sowmya P, Dornadula, Sireesh, Pinni, Sudheer, Rampa, Dileep R, Reddy, Raju C

“…Asthma is a serious, growing problem worldwide. Inhaled steroids, the current standard therapy, are not always effective in this chronic inflammatory disease…”
Get full text

Endothelial cell peroxisome proliferator-activated receptor γ reduces endotoxemic pulmonary inflammation and injury by Reddy, Aravind T, Lakshmi, Sowmya P, Kleinhenz, Jennifer M, Sutliff, Roy L, Hart, C Michael, Reddy, Raju C

“…Bacterial endotoxin (LPS)-mediated sepsis involves severe, dysregulated inflammation that injures the lungs and other organs, often fatally. Vascular…”
Get full text

Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ 12,14 -prostaglandin J 2 by Reddy, Aravind T, Lakshmi, Sowmya P, Banno, Asoka, Reddy, Raju C

“…PPARδ belongs to the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors. Upon activation by an agonist, PPARδ controls a variety of…”
Get full text