Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate

Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate

The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24h with phytohaemagglutinin and then exposed for 20h to an adaptive dose (AD) of a 1950MHz R...

Full description

Saved in:
Bibliographic Details
Published in:Mutation research Vol. 747; no. 1; pp. 29 - 35
Main Authors: Zeni, Olga, Sannino, Anna, Romeo, Stefania, Massa, Rita, Sarti, Maurizio, Reddy, Abishek B., Prihoda, Thomas J., Vijayalaxmi, Scarfì, Maria Rosaria
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 30-08-2012
Elsevier BV
Subjects:
Adaptation, Physiological - radiation effects
Adaptive response
Cell culture
Cells, Cultured
Cytotoxicity
Data processing
Dose-Response Relationship, Radiation
Genotoxicity
Hemagglutinins
Human blood lymphocytes
Humans
Lymphocytes
Lymphocytes - radiation effects
Manganese
Micronuclei
Micronuclei, Chromosome-Defective
Mitomycin - pharmacology
Mitomycin C
Mobile communications networks
Mutagenesis
Peripheral blood
Radiation Tolerance
Radio frequency
Radio Waves
Radiofrequency fields
Signaling
Specific absorption rate
UMTS signal
UMTS signal
Radiofrequency fields
Human blood lymphocytes
Specific absorption rate
Micronuclei
Adaptive response
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24h with phytohaemagglutinin and then exposed for 20h to an adaptive dose (AD) of a 1950MHz RF UMTS (universal mobile telecommunication system) signal used for mobile communications, at different specific absorption rates (SAR) of 1.25, 0.6, 0.3, and 0.15W/kg. This was followed by treatment of the cells at 48h with a challenge dose (CD) of 100ng/ml mitomycin C (MMC). Lymphocytes were collected at the end of the 72h total culture period. The cytokinesis-block method was used to record the frequency of micronuclei (MN) as genotoxicity end-point. When lymphocytes from six donors were pre-exposed to RF at 0.3W/kg SAR and then treated with MMC, these cells showed a significant reduction in the frequency of MN, compared with the cells treated with MMC alone; this result is indicative of induction of AR. The results from our earlier study indicated that lymphocytes that were stimulated for 24h, exposed for 20h to a 900MHz RF GSM (global system for mobile communication) signal at 1.25W/kg SAR and then treated with 100ng/ml MMC, also exhibited AR. These overall data suggest that the induction of AR depends on RF frequency, type of the signal and SAR. Further characterization of RF-induced AR is in progress.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1383-5718
0027-5107
1879-3592
DOI:10.1016/j.mrgentox.2012.03.013