Search Results - "Reddin, Ian"

Large inherent variability in data derived from highly standardised cell culture experiments by Reddin, Ian G., Fenton, Tim R., Wass, Mark N., Michaelis, Martin

“…Cancer drug development is hindered by high clinical attrition rates, which are blamed on weak predictive power by preclinical models and limited replicability…”
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Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis by Basyuni, Shadi, Nugent, Gareth, Ferro, Ashley, Barker, Eleanor, Reddin, Ian, Jones, Oliver, Lechner, Matt, O’Leary, Ben, Jones, Terry, Masterson, Liam, Fenton, Tim, Schache, Andrew

“…This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of…”
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Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance by Chakravarthy, Ankur, Reddin, Ian, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, Rodriguez, Daniela Rothschild, Martinez, Natalia Gonzalez, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S., Skingen, Vilde Eide, Lyng, Heidi, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lechner, Matt, Ellis, Peter J. I., Wass, Mark, Michaelis, Martin, Fiegl, Heidi, Salvesen, Helga, Thomas, Gareth J., Doorbar, John, Chester, Kerry, Feber, Andrew, Fenton, Tim R.

“…Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643…”
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Epigenetic profiling of prostate cancer reveals potential prognostic signatures by Bernatz, Simon, Reddin, Ian G., Fenton, Tim R., Vogl, Thomas J., Wild, Peter J., Köllermann, Jens, Mandel, Philipp, Wenzel, Mike, Hoeh, Benedikt, Mahmoudi, Scherwin, Koch, Vitali, Grünewald, Leon D., Hammerstingl, Renate, Döring, Claudia, Harter, Patrick N., Weber, Katharina J.

“…Purpose While epigenetic profiling discovered biomarkers in several tumor entities, its application in prostate cancer is still limited. We explored DNA…”
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Changes associated with Ebola virus adaptation to novel species by Pappalardo, Morena, Reddin, Ian G, Cantoni, Diego, Rossman, Jeremy S, Michaelis, Martin, Wass, Mark N

“…Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze…”
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Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells by O'Brien, Eleanor, Tse, Carmen, Tracy, Ian, Reddin, Ian, Selfe, Joanna, Gibson, Jane, Tapper, William, Pengelly, Reuben J, Gao, Jinhui, Aladowicz, Ewa, Petts, Gemma, Thway, Khin, Popov, Sergey, Kelsey, Anna, Underwood, Timothy J, Shipley, Janet, Walters, Zoë S

“…Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic…”
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YM155-Adapted Cancer Cell Lines Reveal Drug-Induced Heterogeneity and Enable the Identification of Biomarker Candidates for the Acquired Resistance Setting by Michaelis, Martin, Wass, Mark N, Reddin, Ian, Voges, Yvonne, Rothweiler, Florian, Hehlgans, Stephanie, Cinatl, Jaroslav, Mernberger, Marco, Nist, Andrea, Stiewe, Thorsten, Rödel, Franz, Cinatl, Jr, Jindrich

“…Survivin is a drug target and its suppressant YM155 a drug candidate mainly investigated for high-risk neuroblastoma. Findings from one YM155-adapted subline…”
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Gastroschisis associated changes in the placental transcriptome by Jongen, Maaike, Reddin, Ian, Cave, Sharon, Cashmore, Lianne, Pond, Jenny, Cleal, Jane K., Hall, Nigel J., Lewis, Rohan M.

“…The congenital condition gastroschisis is associated with delayed villous development and placental malperfusion, suggesting placental involvement. This study…”
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Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma by Smith, Nicola J, Reddin, Ian, Policelli, Paige, Oh, Sunwoo, Zainal, Nur, Howes, Emma, Jenkins, Benjamin, Tracy, Ian, Edmond, Mark, Sharpe, Benjamin, Amendra, Damian, Zheng, Ke, Egawa, Nagayasu, Doorbar, John, Rao, Anjali, Mahadevan, Sangeetha, Carpenter, Michael A, Harris, Reuben S, Ali, Simak, Hanley, Christopher, Buisson, Rémi, King, Emma, Thomas, Gareth J, Fenton, Tim R

“…Abstract Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, generate somatic mutations in cancer, thereby driving tumour development and drug…”
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Residual cancer cells after apparent complete pathological response to neoadjuvant therapy in oesophageal adenocarcinoma by Walker, Robert C, Harrington, Jack, Breininger, Stella P, Pickering, Oliver, Hill, Samuel L, Sharpe, Benjamin P, Grace, Ben, Reddin, Ian, Rajak, Rushda, Manousopoulou, Antigoni, Garbis, Spiros D, Walters, Zoë S, Rose-Zerilli, Matthew J J, Underwood, Timothy J

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Approaches for the Exploitation of Data Derived from Pharmacogenomics Screens by Reddin, Ian Gary

“…Since the discovery of the first immortal cell line HeLa in 1951, cancer cell lines (CCLs) have been a mainstay of cancer research. But it was not until the…”
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