A retrospective clinicopathological study of 131 cases with endometrial cancers--is it possible to define the role of retroperitoneal lymphadenectomy in low-resource settings?

The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor grades, and their implications on lymph node metastasis. We conducted a retrospective descriptive study of 131 cases of endometrial cancer examined and treated a...

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Bibliographic Details
Published in:	Indian journal of cancer Vol. 51; no. 1; p. 54
Main Authors:	Rathod, P S, Reddihalli, P V, Krishnappa, S, Devi, U K, Bafna, U D
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-01-2014 Medknow Publications & Media Pvt. Ltd
Subjects:	Adult Aged Aged, 80 and over Cancer Care and treatment Clinical pathology Complications and side effects Endometrial cancer Endometrial Neoplasms - economics Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Female Follow-Up Studies Health Resources - economics Humans Hysterectomy - economics Lymph Node Excision - economics Lymphatic Metastasis Middle Aged Neoplasm Grading Oncology, Experimental Prognosis Retroperitoneal Neoplasms - economics Retroperitoneal Neoplasms - secondary Retroperitoneal Neoplasms - surgery Retrospective Studies Risk factors India
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Summary:	The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor grades, and their implications on lymph node metastasis. We conducted a retrospective descriptive study of 131 cases of endometrial cancer examined and treated at a tertiary regional cancer institute between the years 2003 and 2009. We reviewed the oncology database as well as the clinical records and surgico-pathological registry of all these patients. Statistical Methods Used: All the summary measure computation and Chi-square test for comparing more than one proportion was done in spreadsheet (Excel). The multiparity association with endometrial cancer was commonly seen 113/131 (86.2%). Twelve (9.7%) patients preoperatively diagnosed as Grade 1 tumors upgraded to Grade 3 changes in postoperative specimens and six of these 12 patients (50%) had lymph node metastasis. A total of 14/131 (10.6%) cases had lymph nodes metastasis. There is a poor correlation between the preoperative and the postoperative tumor grades. Routine pelvic lymphadenectomy may be a valuable method in low-risk cases and para-aortic lymphadenectomy may be limited to high-risk endometrial cancers.
ISSN:	0019-509X 1998-4774
DOI:	10.4103/0019-509X.134628