Search Results - "Reddick, Robert L."

Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas by Toledo, Rodrigo A, Qin, Yuejuan, Cheng, Zi-Ming, Gao, Qing, Iwata, Shintaro, Silva, Gustavo M, Prasad, Manju L, Ocal, I Tolgay, Rao, Sarika, Aronin, Neil, Barontini, Marta, Bruder, Jan, Reddick, Robert L, Chen, Yidong, Aguiar, Ricardo C T, Dahia, Patricia L M

“…Pheochromocytomas and paragangliomas (PPGL) are genetically heterogeneous tumors of neural crest origin, but the molecular basis of most PPGLs is unknown. We…”
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Perfluorocarbons cause thrombocytopenia, changes in RBC morphology and death in a baboon model of systemic inflammation by Pidcoke, Heather F, Delacruz, Wilfred, Herzig, Maryanne C, Schaffer, Beverly S, Leazer, Sahar T, Fedyk, Chriselda G, Montogomery, Robbie K, Prat, Nicolas J, Parida, Bijaya K, Aden, James K, Scherer, Michael R, Reddick, Robert L, Shade, Robert E, Cap, Andrew P

“…A perfluorocarbon (PFC) investigated for treatment of traumatic brain injury (TBI) delivers oxygen to support brain function, but causes transient…”
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Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis by GUIMING LI, RIVAS, Paul, BEDOLLA, Roble, THAPA, Dinesh, REDDICK, Robert L, GHOSH, Rita, KUMAR, Addanki P

“…SIRT1 (mammalian ortholog of the yeast silent information regulator 2) is a NAD-dependent histone deacetylase belonging to the multigene family of sirtuins…”
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The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner by Srikantan, Subramanya, Deng, Yilun, Cheng, Zi-Ming, Luo, Anqi, Qin, Yuejuan, Gao, Qing, Sande-Docor, Glaiza-Mae, Tao, Sifan, Zhang, Xingyu, Harper, Nathan, Shannon, Chris E., Fourcaudot, Marcel, Li, Zhi, Kasinath, Balakuntalam S., Harrison, Stephen, Ahuja, Sunil, Reddick, Robert L., Dong, Lily Q., Abdul-Ghani, Muhammad, Norton, Luke, Aguiar, Ricardo C. T., Dahia, Patricia L. M.

“…Understanding the molecular components of insulin signaling is relevant to effectively manage insulin resistance. We investigated the phenotype of the TMEM127…”
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Diabetic eNOS knockout mice develop distinct macro- and microvascular complications by Mohan, Sumathy, Reddick, Robert L, Musi, Nicolas, Horn, Diane A, Yan, Bo, Prihoda, Thomas J, Natarajan, Mohan, Abboud-Werner, Sherry L

“…Functional consequences of impaired endothelial nitric oxide synthase (eNOS) activity causing organ-specific abnormalities on a diabetic setting are not…”
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Intra-organ variation in age-related mutation accumulation in the mouse by Busuttil, Rita A, Garcia, Ana Maria, Reddick, Robert L, Dollé, Martijn E T, Calder, Robert B, Nelson, James F, Vijg, Jan

“…Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age…”
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CC chemokine receptor 5 influences late-stage atherosclerosis by Quinones, Marlon P, Martinez, Hernan G, Jimenez, Fabio, Estrada, Carlos A, Dudley, Molly, Willmon, Opal, Kulkarni, Hemant, Reddick, Robert L, Fernandes, Gabriel, Kuziel, William A, Ahuja, Sunil K, Ahuja, Seema S

“…Abstract Members of the chemokine system, play a central role in inflammatory processes that underlie the pathogenesis of atherosclerosis and possibly, aortic…”
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Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis by Quinones, Marlon P, Ahuja, Sunil K, Jimenez, Fabio, Schaefer, Jason, Garavito, Edgar, Rao, Arun, Chenaux, George, Reddick, Robert L, Kuziel, William A, Ahuja, Seema S

“…The prevailing paradigm is that in human rheumatoid arthritis (RA), the accumulation of monocytes and T cells in the joint, mediated in part by such CC…”
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Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E by Zhang, Sunny H., Reddick, Robert L., Piedrahita, Jorge A., Maeda, Nobuyo

“…Apolipoprotein E (apoE) is a ligand for receptors that clear remnants of chylomicrons and very low density lipoproteins. Lack of apoE is, therefore, expected…”
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NFκB Regulates Muscle Development and Mitochondrial Function by Valentine, Joseph M, Li, Mengyao E, Shoelson, Steven E, Zhang, Ning, Reddick, Robert L, Musi, Nicolas

“…Abstract Nuclear factor (NF)κB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated…”
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Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite by Fox, Raymond, Kim, Hyung-Suk, Reddick, Robert L, Kujoth, Gregory C, Prolla, Tomas A, Tsutsumi, Shuichi, Wada, Youichiro, Smithies, Oliver, Maeda, Nobuyo

“…Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain…”
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NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis by Thapa, Dinesh, Meng, Peng, Bedolla, Roble G, Reddick, Robert L, Kumar, Addanki P, Ghosh, Rita

“…NADPH reductase quinone oxidoreductase 1 (NQO1) is needed to maintain a cellular pool of antioxidants, and this enzyme may contribute to tumorigenesis on the…”
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SIRT1 inhibition‐induced senescence as a strategy to prevent prostate cancer progression by Huang, Shih‐Bo, Rivas, Paul, Yang, Xiaoyu, Lai, Zhao, Chen, Yidong, Schadler, Keri L., Hu, Ming, Reddick, Robert L., Ghosh, Rita, Kumar, Addanki P.

“…Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)‐dependent deacetylase in cancer development, progression and…”
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Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells by Zanotto-Filho, Alfeu, Rajamanickam, Subapriya, Loranc, Eva, Masamsetti, V. Pragathi, Gorthi, Aparna, Romero, July Carolina, Tonapi, Sonal, Gonçalves, Rosangela Mayer, Reddick, Robert L., Benavides, Raymond, Kuhn, John, Chen, Yidong, Bishop, Alexander J.R.

“…Molecular targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using low dose of the multikinase inhibitor…”
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Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation by Hussain, Suleman S., Huang, Shih-Bo, Bedolla, Roble G., Rivas, Paul, Basler, Joseph W., Swanson, Gregory P., Hui-Ming Huang, Tim, Narayanasamy, Ganesh, Papanikolaou, Nikos, Miyamoto, Hiroshi, Yeh, I-Tien, Reddick, Robert L., Pollock, Brad H., Ghosh, Rita, Kumar, Addanki P.

“…Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further…”
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A Unique Case of Metastatic, Functional, Hereditary Paraganglioma Associated With an SDHC Germline Mutation by Ong, Raquel Kristin S, Flores, Shahida K, Reddick, Robert L, Dahia, Patricia L M, Shawa, Hassan

“…Abstract Context Mutations in genes encoding for the succinate dehydrogenase (SDH) complex are linked to hereditary paraganglioma syndromes. Paraganglioma…”
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Receptor tyrosine kinase recepteur d'origine nantais as predictive marker for aggressive prostate cancer in African Americans by Bedolla, Roble G., Shah, Dimpy P., Huang, Shih‐Bo, Reddick, Robert L., Ghosh, Rita, Kumar, Addanki P.

“…Published evidence shows a correlation between several molecular markers and prostate cancer (PCa) progression including in African Americans (AAs) who are…”
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Endothelial cell-specific overexpression of endothelial nitric oxide synthase in Ins2Akita mice exacerbates diabetic nephropathy by Natarajan, Mohan, Habib, Samy L., Reddick, Robert L., Delma, Caroline R., Manickam, Krishnan, Prihoda, Thomas J., Werner, Sherry L., Mohan, Sumathy

“…Previous studies demonstrated that global deficiency of eNOS in diabetic mice exacerbated renal lesions and that overexpression of eNOS may protect against…”
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Enhancing eNOS activity with simultaneous inhibition of IKKβ restores vascular function in Ins2(Akita+/-) type-1 diabetic mice by Krishnan, Manickam, Janardhanan, Preethi, Roman, Linda, Reddick, Robert L, Natarajan, Mohan, van Haperen, Rien, Habib, Samy L, de Crom, Rini, Mohan, Sumathy

“…The balance of nitric oxide (NO) versus superoxide generation has a major role in the initiation and progression of endothelial dysfunction. Under conditions…”
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A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands by Qin, Tai, Barron, Lindsey, Xia, Lu, Huang, Haojie, Villarreal, Maria M, Zwaagstra, John, Collins, Cathy, Yang, Junhua, Zwieb, Christian, Kodali, Ravindra, Hinck, Cynthia S, Kim, Sun Kyung, Reddick, Robert L, Shu, Chang, O'Connor-McCourt, Maureen D, Hinck, Andrew P, Sun, Lu-Zhe

“…The effects of transforming growth factor beta (TGF-β) signaling on prostate tumorigenesis has been shown to be strongly dependent on the stage of development,…”
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