Search Results - "Reddi, Amit R"

Heme Mobilization in Animals: A Metallolipid’s Journey by Reddi, Amit R, Hamza, Iqbal

“…Heme is universally recognized as an essential and ubiquitous prosthetic group that enables proteins to carry out a diverse array of functions. All…”
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SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration by Reddi, Amit R., Culotta, Valeria C.

“…Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as a regulator of antioxidant defense. Using the yeast Saccharomyces…”
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Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications by Lei, Xin Gen, Zhu, Jian-Hong, Cheng, Wen-Hsing, Bao, Yongping, Ho, Ye-Shih, Reddi, Amit R, Holmgren, Arne, Arnér, Elias S J

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as…”
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Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors by Hanna, David A., Harvey, Raven M., Martinez-Guzman, Osiris, Yuan, Xiaojing, Chandrasekharan, Bindu, Raju, Gheevarghese, Outten, F. Wayne, Hamza, Iqbal, Reddi, Amit R.

“…Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and heme signaling are ultimately reliant on the ability to mobilize labile…”
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Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome by Montllor-Albalate, Claudia, Kim, Hyojung, Thompson, Anna E, Jonke, Alex P, Torres, Matthew P, Reddi, Amit R

“…Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O ) by catalyzing its conversion to…”
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Regulation of intracellular heme trafficking revealed by subcellular reporters by Yuan, Xiaojing, Rietzschel, Nicole, Kwon, Hanna, Nuno, Ana Beatriz Walter, Hanna, David A., Phillips, John D., Raven, Emma L., Reddi, Amit R., Hamza, Iqbal

“…Heme is an essential prosthetic group in proteins that reside in virtually every subcellular compartment performing diverse biological functions. Irrespective…”
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Multiple prebiotic metals mediate translation by Bray, Marcus S., Lenz, Timothy K., Haynes, Jay William, Bowman, Jessica C., Petrov, Anton S., Reddi, Amit R., Hud, Nicholas V., Williams, Loren Dean, Glass, Jennifer B.

“…Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested…”
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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme by Swenson, Samantha A, Moore, Courtney M, Marcero, Jason R, Medlock, Amy E, Reddi, Amit R, Khalimonchuk, Oleh

“…Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed…”
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Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae by Montllor-Albalate, Claudia, Colin, Alyson E, Chandrasekharan, Bindu, Bolaji, Naimah, Andersen, Joshua L, Wayne Outten, F, Reddi, Amit R

“…Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen…”
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Probing in vivo Mn²⁺ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy by McNaughton, Rebecca L, Reddi, Amit R, Clement, Matthew H.S, Sharma, Ajay, Barnese, Kevin, Rosenfeld, Leah, Gralla, Edith Butler, Valentine, Joan Selverstone, Culotta, Valeria C, Hoffman, Brian M

“…Manganese is an essential transition metal that, among other functions, can act independently of proteins to either defend against or promote oxidative stress…”
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Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase by Dietz, Jonathan V., Willoughby, Mathilda M., Piel, Robert B., Ross, Teresa A., Bohovych, Iryna, Addis, Hannah G., Fox, Jennifer L., Lanzilotta, William N., Dailey, Harry A., Wohlschlegel, James A., Reddi, Amit R., Medlock, Amy E., Khalimonchuk, Oleh

“…Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned…”
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The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection by Reddi, Amit R., Jensen, Laran T., Naranuntarat, Amornrat, Rosenfeld, Leah, Leung, Edison, Shah, Rishita, Culotta, Valeria C.

“…In various organisms, high intracellular manganese provides protection against oxidative damage through unknown pathways. Herein we use a genetic approach in…”
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Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration by Banks, Courtney J., Rodriguez, Nathan W., Gashler, Kyle R., Pandya, Rushika R., Mortenson, Jeffrey B., Whited, Matthew D., Soderblom, Erik J., Thompson, J. Will, Moseley, M. Arthur, Reddi, Amit R., Tessem, Jeffery S., Torres, Matthew P., Bikman, Benjamin T., Andersen, Joshua L.

“…In this study, we employed proteomics to identify mechanisms of posttranslational regulation on cell survival signaling proteins. We focused on Cu-Zn…”
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Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis by Donegan, Rebecca K, Fu, Yibo, Copeland, Jacqueline, Idga, Stanzin, Brown, Gabriel, Hale, Owen F, Mitra, Avishek, Yang, Hui, Dailey, Harry A, Niederweis, Michael, Jain, Paras, Reddi, Amit R

“…Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M…”
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Analysis of hypoxia and hypoxia-like states through metabolite profiling by Gleason, Julie E, Corrigan, David J, Cox, James E, Reddi, Amit R, McGinnis, Lauren A, Culotta, Valeria C

“…In diverse organisms, adaptation to low oxygen (hypoxia) is mediated through complex gene expression changes that can, in part, be mimicked by exposure to…”
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One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers by Chambers, Ian G., Willoughby, Mathilda M., Hamza, Iqbal, Reddi, Amit R.

“…Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with biological membranes. The very same properties of heme that nature…”
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Handling heme: The mechanisms underlying the movement of heme within and between cells by Donegan, Rebecca K., Moore, Courtney M., Hanna, David A., Reddi, Amit R.

“…Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely…”
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Human ribosomal G-quadruplexes regulate heme bioavailability by Mestre-Fos, Santi, Ito, Chieri, Moore, Courtney M., Reddi, Amit R., Williams, Loren Dean

“…The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported. However, their formation in cells and their cellular roles were not…”
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Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells by Sweeny, Elizabeth A., Singh, Anuradha Bharara, Chakravarti, Ritu, Martinez-Guzman, Osiris, Saini, Arushi, Haque, Mohammad Mahfuzul, Garee, Greer, Dans, Pablo D., Hannibal, Luciana, Reddi, Amit R., Stuehr, Dennis J.

“…Cellular heme is thought to be distributed between a pool of sequestered heme that is tightly bound within hemeproteins and a labile heme pool required for…”
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Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors by Hanna, David A, Martinez-Guzman, Osiris, Reddi, Amit R

“…Heme (iron protoporphyrin IX) is an essential protein prosthetic group and signaling molecule required for most life on Earth. All heme-dependent processes…”
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