Search Results - "Reddi, Amit"

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration by Reddi, Amit R., Culotta, Valeria C.

“…Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as a regulator of antioxidant defense. Using the yeast Saccharomyces…”
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Heme Mobilization in Animals: A Metallolipid’s Journey by Reddi, Amit R, Hamza, Iqbal

“…Heme is universally recognized as an essential and ubiquitous prosthetic group that enables proteins to carry out a diverse array of functions. All…”
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One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers by Chambers, Ian G., Willoughby, Mathilda M., Hamza, Iqbal, Reddi, Amit R.

“…Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with biological membranes. The very same properties of heme that nature…”
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Handling heme: The mechanisms underlying the movement of heme within and between cells by Donegan, Rebecca K., Moore, Courtney M., Hanna, David A., Reddi, Amit R.

“…Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely…”
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Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications by Lei, Xin Gen, Zhu, Jian-Hong, Cheng, Wen-Hsing, Bao, Yongping, Ho, Ye-Shih, Reddi, Amit R, Holmgren, Arne, Arnér, Elias S J

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as…”
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Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors by Hanna, David A., Harvey, Raven M., Martinez-Guzman, Osiris, Yuan, Xiaojing, Chandrasekharan, Bindu, Raju, Gheevarghese, Outten, F. Wayne, Hamza, Iqbal, Reddi, Amit R.

“…Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and heme signaling are ultimately reliant on the ability to mobilize labile…”
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Human ribosomal G-quadruplexes regulate heme bioavailability by Mestre-Fos, Santi, Ito, Chieri, Moore, Courtney M., Reddi, Amit R., Williams, Loren Dean

“…The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported. However, their formation in cells and their cellular roles were not…”
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Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome by Montllor-Albalate, Claudia, Kim, Hyojung, Thompson, Anna E, Jonke, Alex P, Torres, Matthew P, Reddi, Amit R

“…Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant enzyme that detoxifies superoxide (O ) by catalyzing its conversion to…”
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Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells by Sweeny, Elizabeth A., Singh, Anuradha Bharara, Chakravarti, Ritu, Martinez-Guzman, Osiris, Saini, Arushi, Haque, Mohammad Mahfuzul, Garee, Greer, Dans, Pablo D., Hannibal, Luciana, Reddi, Amit R., Stuehr, Dennis J.

“…Cellular heme is thought to be distributed between a pool of sequestered heme that is tightly bound within hemeproteins and a labile heme pool required for…”
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Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors by Hanna, David A, Martinez-Guzman, Osiris, Reddi, Amit R

“…Heme (iron protoporphyrin IX) is an essential protein prosthetic group and signaling molecule required for most life on Earth. All heme-dependent processes…”
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Regulation of intracellular heme trafficking revealed by subcellular reporters by Yuan, Xiaojing, Rietzschel, Nicole, Kwon, Hanna, Nuno, Ana Beatriz Walter, Hanna, David A., Phillips, John D., Raven, Emma L., Reddi, Amit R., Hamza, Iqbal

“…Heme is an essential prosthetic group in proteins that reside in virtually every subcellular compartment performing diverse biological functions. Irrespective…”
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HRG-9 homologues regulate haem trafficking from haem-enriched compartments by Sun, Fengxiu, Zhao, Zhenzhen, Willoughby, Mathilda M., Shen, Shuaiqi, Zhou, Yu, Shao, Yiyan, Kang, Jing, Chen, Yongtian, Chen, Mengying, Yuan, Xiaojing, Hamza, Iqbal, Reddi, Amit R., Chen, Caiyong

“…Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes 1 – 3 . Haem binding proteins are present in…”
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Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans by Weissman, Ziva, Pinsky, Mariel, Donegan, Rebecca K., Reddi, Amit R., Kornitzer, Daniel

“…Candida albicans is a major fungal pathogen that can utilise hemin and haemoglobin as iron sources in the iron‐scarce host environment. While C. albicans is a…”
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Measuring the Oxidation State and Enzymatic Activity of Glyceraldehyde Phosphate Dehydrogenase (GAPDH) by Montllor-Albalate, Claudia, Thompson, Anna E, Kim, Hyojung, Reddi, Amit R

“…Glyceraldehyde phosphate dehydrogenase (GAPDH) is a highly conserved, essential, and abundant enzyme that catalyzes a rate-determining step of glycolysis…”
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Multiple prebiotic metals mediate translation by Bray, Marcus S., Lenz, Timothy K., Haynes, Jay William, Bowman, Jessica C., Petrov, Anton S., Reddi, Amit R., Hud, Nicholas V., Williams, Loren Dean, Glass, Jennifer B.

“…Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested…”
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Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites by Martinez-Guzman, Osiris, Willoughby, Mathilda M, Saini, Arushi, Dietz, Jonathan V, Bohovych, Iryna, Medlock, Amy E, Khalimonchuk, Oleh, Reddi, Amit R

“…Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is…”
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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme by Swenson, Samantha A, Moore, Courtney M, Marcero, Jason R, Medlock, Amy E, Reddi, Amit R, Khalimonchuk, Oleh

“…Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed…”
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Heme bioavailability and signaling in response to stress in yeast cells by Hanna, David A., Hu, Rebecca, Kim, Hyojung, Martinez-Guzman, Osiris, Torres, Matthew P., Reddi, Amit R.

“…Protoheme (hereafter referred to as heme) is an essential cellular cofactor and signaling molecule that is also potentially cytotoxic. To mitigate heme…”
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Manganese Homeostasis in Saccharomyces cerevisiae by Reddi, Amit R, Jensen, Laran T, Culotta, Valeria C

“…Reddi et al discuss the manganese homeostasis in the eukaryotic cell of Saccharomyces cerevisiae…”
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Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway by Chandrasekharan, Bindu, Montllor-Albalate, Claudia, Colin, Alyson E., Andersen, Joshua L., Jang, Young C., Reddi, Amit R.

“…Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key…”
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