Search Results - "Reddem, Eswar"

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite by Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence

“…Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal…”
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Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies by Cerutti, Gabriele, Rapp, Micah, Guo, Yicheng, Bahna, Fabiana, Bimela, Jude, Reddem, Eswar R., Yu, Jian, Wang, Pengfei, Liu, Lihong, Huang, Yaoxing, Ho, David D., Kwong, Peter D., Sheng, Zizhang, Shapiro, Lawrence

“…Emerging SARS-CoV-2 strains, B.1.1.7 and B.1.351, from the UK and South Africa, respectively, show decreased neutralization by monoclonal antibodies and…”
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Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid by Mayer, Clemens, Dulson, Christopher, Reddem, Eswar, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard

“…The impressive rate accelerations that enzymes display in nature often result from boosting the inherent catalytic activities of side chains by their precise…”
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Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain by Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Wang, Maple, Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence

“…Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing…”
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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class by Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang

“…Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2…”
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An Artificial Heme Enzyme for Cyclopropanation Reactions by Villarino, Lara, Splan, Kathryn E., Reddem, Eswar, Alonso‐Cotchico, Lur, Gutiérrez de Souza, Cora, Lledós, Agustí, Maréchal, Jean‐Didier, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard

“…An artificial heme enzyme was created through self‐assembly from hemin and the lactococcal multidrug resistance regulator (LmrR). The crystal structure shows…”
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Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme–Cofactor Intermediate Stability by Börner, Tim, Rämisch, Sebastian, Reddem, Eswar R, Bartsch, Sebastian, Vogel, Andreas, Thunnissen, Andy-Mark W. H, Adlercreutz, Patrick, Grey, Carl

“…The insufficient operational stability of amine transaminases (ATA) constitutes a limiting factor for high productivity in chiral amine synthesis. In this…”
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Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties by Gierse, Robin M., Reddem, Eswar R., Alhayek, Alaa, Baitinger, Dominik, Hamid, Zhoor, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K.H., Groves, Matthew R.

“…In this report, we describe a truncated Deinococcus radiodurans 1-deoxy-D-xylulose-5-phosphate synthase (DXS) protein that retains enzymatic activity, while…”
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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking by Liu, Lihong, Casner, Ryan G., Guo, Yicheng, Wang, Qian, Iketani, Sho, Chan, Jasper Fuk-Woo, Yu, Jian, Dadonaite, Bernadeta, Nair, Manoj S., Mohri, Hiroshi, Reddem, Eswar R., Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Yuen, Kwok-Yung, Sheng, Zizhang, Huang, Yaoxing, Bloom, Jesse D., Shapiro, Lawrence, Ho, David D.

“…SARS-CoV-2 continues to evolve, with many variants evading clinically authorized antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing…”
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First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization by Gierse, Robin M., Oerlemans, Rick, Reddem, Eswar R., Gawriljuk, Victor O., Alhayek, Alaa, Baitinger, Dominik, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K. H., Groves, Matthew R.

“…The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most…”
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Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme by Villarino, Lara, Chordia, Shreyans, Alonso-Cotchico, Lur, Reddem, Eswar, Zhou, Zhi, Thunnissen, Andy Mark W. H., Maréchal, Jean-Didier, Roelfes, Gerard

“…We present an artificial metalloenzyme based on the transcriptional regulator LmrR that exhibits dynamics involving the positioning of its abiological metal…”
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An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses by Liu, Lihong, Iketani, Sho, Guo, Yicheng, Reddem, Eswar R, Casner, Ryan G, Nair, Manoj S, Yu, Jian, Chan, Jasper F-W, Wang, Maple, Cerutti, Gabriele, Li, Zhiteng, Morano, Nicholas C, Castagna, Candace D, Corredor, Laura, Chu, Hin, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chun-Sing, Chen, Zhiwei, Luo, Yang, Cunningham, Marcus, Chavez, Alejandro, Yin, Michael T, Perlin, David S, Tsuji, Moriya, Yuen, Kwok-Yung, Kwong, Peter D, Sheng, Zizhang, Huang, Yaoxing, Shapiro, Lawrence, Ho, David D

“…The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made clear the importance of pandemic preparedness. To address…”
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Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2 by Luo, Mengxiao, Zhou, Biao, Reddem, Eswar R., Tang, Bingjie, Chen, Bohao, Zhou, Runhong, Liu, Hang, Liu, Lihong, Katsamba, Phinikoula S., Au, Ka-Kit, Man, Hiu-On, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Shapiro, Lawrence, Dang, Shangyu, Ho, David D., Chen, Zhiwei

“…Increasing spread by SARS-CoV-2 Omicron variants challenges existing vaccines and broadly reactive neutralizing antibodies (bNAbs) against COVID-19. Here we…”
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Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses by Banach, Bailey B., Cerutti, Gabriele, Fahad, Ahmed S., Shen, Chen-Hsiang, Oliveira De Souza, Matheus, Katsamba, Phinikoula S., Tsybovsky, Yaroslav, Wang, Pengfei, Nair, Manoj S., Huang, Yaoxing, Francino-Urdániz, Irene M., Steiner, Paul J., Gutiérrez-González, Matías, Liu, Lihong, López Acevedo, Sheila N., Nazzari, Alexandra F., Wolfe, Jacy R., Luo, Yang, Olia, Adam S., Teng, I-Ting, Yu, Jian, Zhou, Tongqing, Reddem, Eswar R., Bimela, Jude, Pan, Xiaoli, Madan, Bharat, Laflin, Amy D., Nimrania, Rajani, Yuen, Kwok-Yung, Whitehead, Timothy A., Ho, David D., Kwong, Peter D., Shapiro, Lawrence, DeKosky, Brandon J.

“…Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody,…”
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Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS‐CoV‐2 by Madan, Bharat, Reddem, Eswar R., Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Huang, Yaoxing, Fahad, Ahmed S., Souza, Matheus Oliveira, Banach, Bailey B., López Acevedo, Sheila N., Pan, Xiaoli, Nimrania, Rajani, Teng, I‐Ting, Bahna, Fabiana, Zhou, Tongqing, Zhang, Baoshan, Yin, Michael T., Ho, David D., Kwong, Peter D., Shapiro, Lawrence, DeKosky, Brandon J.

“…Antiviral monoclonal antibody (mAb) discovery enables the development of antibody‐based antiviral therapeutics. Traditional antiviral mAb discovery relies on…”
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Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins by Ames, Jessica R., McGillick, Julia, Murphy, Tamiko, Reddem, Eswar, Bourne, Christina R.

“…The ribosome-dependent E. coli (Ec) mRNase toxin YoeB has been demonstrated to protect cells during thermal stress. Agrobacterium tumefaciens (At), a plant…”
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Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2 by Fukudome, Akihito, Singh, Jasleen, Mishra, Vibhor, Reddem, Eswar, Martinez-Marquez, Francisco, Wenzel, Sabine, Yan, Rui, Shiozaki, Momoko, Yu, Zhiheng, Wang, Joseph Che-Yen, Takagi, Yuichiro, Pikaard, Craig S.

“…RNA-dependent RNA polymerases play essential roles in RNA-mediated gene silencing in eukaryotes. In Arabidopsis, RNA-DEPENDENT RNA POLYMERASE 2 (RDR2)…”
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Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid by Mayer, Clemens, Dulson, Christopher, Reddem, Eswar, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard

“…The impressive rate accelerations that enzymes display in nature often result from boosting the inherent catalytic activities of side chains by their precise…”
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An Artificial Heme Enzyme for Cyclopropanation Reactions by Villarino, Lara, Splan, Kathryn E., Reddem, Eswar, Alonso‐Cotchico, Lur, Gutiérrez de Souza, Cora, Lledós, Agustí, Maréchal, Jean‐Didier, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard

“…An artificial heme enzyme was created through self‐assembly from hemin and the lactococcal multidrug resistance regulator (LmrR). The crystal structure shows…”
Get full text