Search Results - "Reddel, R. R."

Alternative lengthening of telomeres: models, mechanisms and implications by Reddel, Roger R, Cesare, Anthony J

“…Key Points About 10% of all cancers, including some that have a particularly poor prognosis, use the alternative lengthening of telomeres (ALT) pathway to…”
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Molecular mechanisms of activity and derepression of alternative lengthening of telomeres by Pickett, Hilda A, Reddel, Roger R

“…Cancer cells that lack telomerase activity can maintain telomere lengths that permit continued proliferation via a recombination-based pathway called…”
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Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX by de Nonneville, Alexandre, Reddel, Roger R.

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Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers by Henson, Jeremy D., Reddel, Roger R.

“…Alternative Lengthening of Telomeres (ALT) activity can be deduced from the presence of telomere length maintenance in the absence of telomerase activity. More…”
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Telomere maintenance mechanisms in cancer: clinical implications by Reddel, Roger R

“…The presence of immortal cell populations with an up-regulated telomere maintenance mechanism (TMM) is an almost universal characteristic of cancers, whereas…”
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The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) by Lu, Robert, O’Rourke, Julienne J., Sobinoff, Alexander P., Allen, Joshua A. M., Nelson, Christopher B., Tomlinson, Christopher G., Lee, Michael, Reddel, Roger R., Deans, Andrew J., Pickett, Hilda A.

“…The collapse of stalled replication forks is a major driver of genomic instability. Several committed mechanisms exist to resolve replication stress. These…”
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Cancer and Telomeres—An ALTernative to Telomerase by Shay, Jerry W., Reddel, Roger R., Wright, Woodring E.

“…Finding ways to target the alternative (ALT) telomere lengthening pathway found in some cancer cells could complement telomerase inhibitors currently in…”
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Five dysfunctional telomeres predict onset of senescence in human cells by Kaul, Zeenia, Cesare, Anthony J, Huschtscha, Lily I, Neumann, Axel A, Reddel, Roger R

“…Replicative senescence is accompanied by a telomere‐specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early‐passage…”
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The C-Circle Assay for alternative-lengthening-of-telomeres activity by Henson, Jeremy D., Lau, Loretta M., Koch, Sylvia, Martin La Rotta, Nancy, Dagg, Rebecca A., Reddel, Roger R.

“…•The C-Circle Assay (CCA) is a rapid, robust and quantitative measure for ALT activity.•Here we detail the protocols and considerations required to perform the…”
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Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells by Cao, Ying, Bryan, Tracy M., Reddel, Roger R.

“…Telomerase is a ribonucleoprotein enzyme complex that adds telomeric repeats to the ends of chromosomes. The core telomerase components are the telomerase…”
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Strategies to enable large-scale proteomics for reproducible research by Poulos, Rebecca C., Hains, Peter G., Shah, Rohan, Lucas, Natasha, Xavier, Dylan, Manda, Srikanth S., Anees, Asim, Koh, Jennifer M. S., Mahboob, Sadia, Wittman, Max, Williams, Steven G., Sykes, Erin K., Hecker, Michael, Dausmann, Michael, Wouters, Merridee A., Ashman, Keith, Yang, Jean, Wild, Peter J., deFazio, Anna, Balleine, Rosemary L., Tully, Brett, Aebersold, Ruedi, Speed, Terence P., Liu, Yansheng, Reddel, Roger R., Robinson, Phillip J., Zhong, Qing

“…Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass…”
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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway by Lovejoy, Courtney A, Li, Wendi, Reisenweber, Steven, Thongthip, Supawat, Bruno, Joanne, de Lange, Titia, De, Saurav, Petrini, John H J, Sung, Patricia A, Jasin, Maria, Rosenbluh, Joseph, Zwang, Yaara, Weir, Barbara A, Hatton, Charlie, Ivanova, Elena, Macconaill, Laura, Hanna, Megan, Hahn, William C, Lue, Neal F, Reddel, Roger R, Jiao, Yuchen, Kinzler, Kenneth, Vogelstein, Bert, Papadopoulos, Nickolas, Meeker, Alan K

“…The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent pathway for telomere maintenance that is active in a significant subset of…”
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Protein Composition of Catalytically Active Human Telomerase from Immortal Cells by Cohen, Scott B, Graham, Mark E, Lovrecz, George O, Bache, Nicolai, Robinson, Phillip J, Reddel, Roger R

“…Telomerase is a ribonucleoprotein enzyme complex that adds 5'-TTAGGG-3' repeats onto the ends of human chromosomes, providing a telomere maintenance mechanism…”
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Check your cultures! A list of cross‐contaminated or misidentified cell lines by Capes‐Davis, Amanda, Theodosopoulos, George, Atkin, Isobel, Drexler, Hans G., Kohara, Arihiro, MacLeod, Roderick A.F., Masters, John R., Nakamura, Yukio, Reid, Yvonne A., Reddel, Roger R., Freshney, R. Ian

“…Continuous cell lines consist of cultured cells derived from a specific donor and tissue of origin that have acquired the ability to proliferate indefinitely…”
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Telomere maintenance by recombination in human cells by Reddel, Roger R, Dunham, Melissa A, Neumann, Axel A, Fasching, Clare L

“…Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates). In most normal human cells,…”
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Alternative lengthening of telomeres in normal mammalian somatic cells by Neumann, Axel A, Watson, Catherine M, Noble, Jane R, Pickett, Hilda A, Tam, Patrick P L, Reddel, Roger R

“…Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether…”
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Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions by Pickett, Hilda A, Cesare, Anthony J, Napier, Christine E, Reddel, Roger R, Cohen, Scott B, Kaul, Zeenia, Neumann, Axel A

“…Telomeric DNA is protected by the shelterin complex, whose disruption triggers DNA-damage responses, checkpoint activation and chromosomal fusions. Now…”
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Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells by Conomos, Dimitri, Stutz, Michael D, Hills, Mark, Neumann, Axel A, Bryan, Tracy M, Reddel, Roger R, Pickett, Hilda A

“…Telomeres in cells that use the recombination-mediated alternative lengthening of telomeres (ALT) pathway elicit a DNA damage response that is partly…”
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Alternative lengthening of telomeres is characterized by high rates of telomeric exchange by LONDONO-VALLEJO, J. Arturo, DER-SARKISSIAN, Héra, CAZES, Lucien, BACCHETTI, Silvia, REDDEL, Roger R

“…Telomere maintenance activity is a hallmark of cancer. In some telomerase-negative tumors, telomeres become lengthened by alternative lengthening of telomeres…”
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The first molecular details of ALT in human tumor cells by Muntoni, Alessandra, Reddel, Roger R.

“…The activation of a telomere maintenance mechanism (TMM) is indispensable for cellular immortalization, a hallmark of human cancer. Although most human cancers…”
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