Search Results - "Rector, R Scott"

Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications by Thyfault, John P, Rector, R Scott

“…Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clinical problem associated with the obesity epidemic. Hepatic steatosis is linked…”
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Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis by Loman, Brett R, Hernández-Saavedra, Diego, An, Ruopeng, Rector, R Scott

“…Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent and underdiagnosed comorbidity of many chronic diseases that is associated with altered…”
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Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol by Yang, Ming, Qi, Xiaoqiang, Li, Nan, Kaifi, Jussuf T., Chen, Shiyou, Wheeler, Andrew A., Kimchi, Eric T., Ericsson, Aaron C., Rector, R. Scott, Staveley-O’Carroll, Kevin F., Li, Guangfu

“…The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease and its progression to non-alcoholic…”
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Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD by Moore, Mary P., Cunningham, Rory P., Meers, Grace M., Johnson, Sarah A., Wheeler, Andrew A., Ganga, Rama R., Spencer, Nicole M., Pitt, James B., Diaz‐Arias, Alberto, Swi, Ahmed I. A., Hammoud, Ghassan M., Ibdah, Jamal A., Parks, Elizabeth J., Rector, R. Scott

“…Background and Aims NAFLD and its more‐advanced form, steatohepatitis (NASH), is associated with obesity and is an independent risk factor for cardiovascular,…”
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Energy-matched moderate and high intensity exercise training improves nonalcoholic fatty liver disease risk independent of changes in body mass or abdominal adiposity — A randomized trial by Winn, Nathan C., Liu, Ying, Rector, R. Scott, Parks, Elizabeth J., Ibdah, Jamal A., Kanaley, Jill A.

“…Exercise training is commonly prescribed for individuals diagnosed with nonalcoholic fatty liver disease (NAFLD); however, consensus regarding the volume and…”
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High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress[S] by Townsend, Logan K., Medak, Kyle D., Peppler, Willem T., Meers, Grace M., Rector, R. Scott, LeBlanc, Paul J., Wright, David C.

“…The relationship between liver interleukin-6 (IL-6) resistance following high-fat diet (HFD)-induced obesity and glucose intolerance is unclear. The purpose of…”
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Does physical inactivity cause nonalcoholic fatty liver disease? by SCOTT RECTOR, R, THYFAULT, John P

“…While physical activity represents a key element in the prevention and management of many chronic diseases, we and others believe that physical inactivity is a…”
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eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH by Sheldon, Ryan D, Meers, Grace M, Morris, E Matthew, Linden, Melissa A, Cunningham, Rory P, Ibdah, Jamal A, Thyfault, John P, Laughlin, M Harold, Rector, R Scott

“…Dysregulated mitochondrial quality control leads to mitochondrial functional impairments that are central to the development and progression of hepatic…”
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The role of angiotensin II in nonalcoholic steatohepatitis by Matthew Morris, E., Fletcher, Justin A., Thyfault, John P., Scott Rector, R.

“…► We review the role of local and systemic AngII signaling in hepatic steatosis. ► We review the association between AngII and decreased mitochondrial…”
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Relationship between hepatic and mitochondrial ceramides: a novel in vivo method to track ceramide synthesis by Mucinski, Justine M., McCaffrey, Jonas M., Rector, R. Scott, Kasumov, Takhar, Parks, Elizabeth J.

“…Ceramides (CERs) are key intermediate sphingolipids implicated in contributing to mitochondrial dysfunction and the development of multiple metabolic…”
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Nonalcoholic fatty liver disease and mitochondrial dysfunction by Wei, Yongzhong, Rector, R Scott, Thyfault, John P, Ibdah, Jamal A

“…Nonalcoholic fatty liver disease （NAFLD） includes hepatic steatosis, nonalcoholic steatohepatitis （NASH）, fibrosis, and cirrhosis. NAFLD is the most common…”
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Non-alcoholic fatty liver disease and the metabolic syndrome： An update by Rector, R Scott, Thyfault, John P, Wei, Yongzhong, Ibdah, Jamal A

“…Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing…”
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Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running by Hinton, Pamela S, Shankar, Kartik, Eaton, Lynn M, Scott Rector, R

“…Abstract Purpose To examine how the development of obesity and the associated insulin resistance affect bone structural and material properties, and bone…”
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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model by Rector, R. Scott, Thyfault, John P, Uptergrove, Grace M, Morris, E. Matthew, Naples, Scott P, Borengasser, Sarah J, Mikus, Catherine R, Laye, Matthew J, Laughlin, M. Harold, Booth, Frank W, Ibdah, Jamal A

“…Background & Aims In this study, we sought to determine the temporal relationship between hepatic mitochondrial dysfunction, hepatic steatosis and insulin…”
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Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model by Rector, R Scott, Uptergrove, Grace M, Morris, E Matthew, Borengasser, Sarah J, Laughlin, M Harold, Booth, Frank W, Thyfault, John P, Ibdah, Jamal A

“…The maintenance of normal body weight either through dietary modification or being habitually more physically active is associated with reduced incidence of…”
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Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH by Cunningham, Rory P, Moore, Mary P, Dashek, Ryan J, Meers, Grace M, Takahashi, Takamune, Sheldon, Ryan D, Wheeler, Andrew A, Diaz-Arias, Alberto, Ibdah, Jamal A, Parks, Elizabeth J, Thyfault, John P, Rector, R Scott

“…Regulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic fatty liver disease (NAFLD) development and…”
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The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development by Cunningham, Rory P, Sheldon, Ryan D, Rector, R Scott

“…Non-alcoholic fatty liver disease (NAFLD) is comprised of a spectrum of liver injury ranging from excess fat accumulation in the liver (steatosis), to…”
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A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice by Moore, Mary P, Cunningham, Rory P, Davis, Rachel A H, Deemer, Sarah E, Roberts, Brandon M, Plaisance, Eric P, Rector, R Scott

“…Nutritional ketosis as a therapeutic tool has been extended to the treatment of metabolic diseases, including obesity, type 2 diabetes, and nonalcoholic fatty…”
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Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats by Linden, Melissa A, Fletcher, Justin A, Morris, E Matthew, Meers, Grace M, Kearney, Monica L, Crissey, Jacqueline M, Laughlin, M Harold, Booth, Frank W, Sowers, James R, Ibdah, Jamal A, Thyfault, John P, Rector, R Scott

“…Here, we sought to compare the efficacy of combining exercise and metformin for the treatment of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD)…”
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Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis by Sheldon, Ryan D, Nicole Blaize, A, Fletcher, Justin A, Pearson, Kevin J, Donkin, Shawn S, Newcomer, Sean C, Rector, R. Scott

“…Graphical abstract…”
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