Search Results - "Rectenwald, Justin M"

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins by Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H

“…Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place…”
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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library by Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.

“…•Focused DNA-encoded libraries (DELs) are effective in target class hit discovery.•Reader domains of five methyl-lysine reader proteins screened using a…”
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins by Lamb, Kelsey N, Dishman, Sarah N, Waybright, Jarod M, Engelberg, Isabelle A, Rectenwald, Justin M, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Pearce, Kenneth H, James, Lindsey I, Frye, Stephen V

“…The heterochromatin protein 1 (HP1) sub-family of CBX chromodomains are responsible for the recognition of histone H3 lysine 9 tri-methyl (H3K9me3)-marked…”
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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader by Potjewyd, Frances, Turner, Anne-Marie W, Beri, Joshua, Rectenwald, Justin M, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Margolis, David M, Pearce, Kenneth H, Herring, Laura E, James, Lindsey I

“…Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of…”
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PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components by Bashore, Frances M., Foley, Caroline A., Ong, Han Wee, Rectenwald, Justin M., Hanley, Ronan P., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Mills, Christine A., Pearce, Kenneth H., Herring, Laura E., Kireev, Dmitri, Frye, Stephen V., James, Lindsey I.

“…Bivalent chemical degraders, otherwise known as proteolysis-targeting chimeras (PROTACs), have proven to be an efficient strategy for targeting overexpressed…”
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Reprogramming CBX8-PRC1 function with a positive allosteric modulator by Suh, Junghyun L, Bsteh, Daniel, Hart, Bryce, Si, Yibo, Weaver, Tyler M, Pribitzer, Carina, Lau, Roy, Soni, Shivani, Ogana, Heather, Rectenwald, Justin M, Norris, Jacqueline L, Cholensky, Stephanie H, Sagum, Cari, Umana, Jessica D, Li, Dongxu, Hardy, Brian, Bedford, Mark T, Mumenthaler, Shannon M, Lenz, Heinz-Josef, Kim, Yong-Mi, Wang, Gang Greg, Pearce, Ken H, James, Lindsey I, Kireev, Dmitri B, Musselman, Catherine A, Frye, Stephen V, Bell, Oliver

“…Canonical targeting of Polycomb repressive complex 1 (PRC1) to repress developmental genes is mediated by cell-type-specific, paralogous chromobox (CBX)…”
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A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2’s Association with the HUSH Complex by Waybright, Jarod M, Clinkscales, Sarah E, Barnash, Kimberly D, Budziszewski, Gabrielle R, Rectenwald, Justin M, Chiarella, Anna M, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Pearce, Kenneth H, Herring, Laura E, McGinty, Robert K, Hathaway, Nathaniel A, James, Lindsey I

“…The interpretation of histone post-translational modifications (PTMs), specifically lysine methylation, by specific classes of “reader” proteins marks an…”
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Characterization of a Radical Intermediate in Lipoyl Cofactor Biosynthesis by Lanz, Nicholas D, Rectenwald, Justin M, Wang, Bo, Kakar, Elizabeth S, Laremore, Tatiana N, Booker, Squire J, Silakov, Alexey

“…Lipoyl synthase (LipA) catalyzes the final step in the biosynthesis of the lipoyl cofactor, the insertion of two sulfur atoms at C6 and C8 of an n-octanoyl…”
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A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins by Rectenwald, Justin M, Hardy, P Brian, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, James, Lindsey I, Frye, Stephen V, Pearce, Kenneth H

“…Chromatin regulatory complexes localize to specific sites via recognition of posttranslational modifications (PTMs) on N-terminal tails of histone proteins…”
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Technology Development for Inhibitor Discovery of Chromatin Associated Proteins Linked to Lysine Methylation by Rectenwald, Justin M

“…The identification of molecules that tightly bind to therapeutically relevant targets remains one of the biggest challenges in biomedical research. Continued…”
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