Search Results - "Reckelkamm, Stefan Lars"

Effect of interleukin‐17 on periodontitis development: An instrumental variable analysis by Baumeister, Sebastian‐Edgar, Holtfreter, Birte, Lars Reckelkamm, Stefan, Hagenfeld, Daniel, Kocher, Thomas, Alayash, Zoheir, Ehmke, Benjamin, Baurecht, Hansjörg, Nolde, Michael

“…Background Circulating levels of interleukin‐17 (IL‐17) are associated with the presence and severity of periodontitis. However, whether IL‐17 is causal for…”
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No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study by Nolde, Michael, Holtfreter, Birte, Kocher, Thomas, Alayash, Zoheir, Reckelkamm, Stefan Lars, Ehmke, Benjamin, Baurecht, Hansjörg, Baumeister, Sebastian-Edgar

“…Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined…”
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Using genetics to explore complement C5 as a druggable protein in periodontitis by Alayash, Zoheir, Baumeister, Sebastian-Edgar, Holtfreter, Birte, Kocher, Thomas, Baurecht, Hansjörg, Ehmke, Benjamin, Reckelkamm, Stefan Lars, Nolde, Michael

“…An excessively activated or dysregulated complement system has been proven to be a vital contributor to the pathogenesis of periodontitis. It has been…”
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Downregulation of interleukin 6 signaling might reduce the risk of periodontitis: a drug target Mendelian randomization study by Nolde, Michael, Alayash, Zoheir, Reckelkamm, Stefan Lars, Kocher, Thomas, Ehmke, Benjamin, Holtfreter, Birte, Baurecht, Hansjörg, Georgakis, Marios K, Baumeister, Sebastian-Edgar

“…Interleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the development of periodontitis. While the inhibition of the IL-6 receptor…”
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Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis by Alayash, Zoheir, Baumeister, Sebastian-Edgar, Holtfreter, Birte, Kocher, Thomas, Baurecht, Hansjörg, Ehmke, Benjamin, Reckelkamm, Stefan Lars, Nolde, Michael

“…To investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis. Genetic instruments were…”
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Cortisol and periodontitis: Prospective observational and Mendelian randomization studies by Baumeister, Sebastian-Edgar, Reckelkamm, Stefan Lars, Grabe, Hans-Jörgen, Nauck, Matthias, Klinger-König, Johanna, Völzke, Henry, Kocher, Thomas, Friedrich, Nele, Holtfreter, Birte

“…Cortisol has obesogenic, hyperglycemic and immunomodulating effects. Preclinical and observational research suggested that it is associated with periodontitis…”
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Association between total body bone mineral density and periodontitis: A Mendelian randomization study by Alayash, Zoheir, Baumeister, Sebastian‐Edgar, Reckelkamm, Stefan Lars, Holtfreter, Birte, Kocher, Thomas, Baurecht, Hansjörg, Ehmke, Benjamin, Nolde, Michael

“…Background The purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian…”
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Understanding the consequences of educational inequalities on periodontitis: A Mendelian randomization study by Baumeister, Sebastian‐Edgar, Freuer, Dennis, Baurecht, Hansjörg, Reckelkamm, Stefan Lars, Ehmke, Benjamin, Holtfreter, Birte, Nolde, Michael

“…Aim Higher educational attainment is associated with a lower risk of periodontitis, but the extent to which this association is causal and mediated by…”
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A Mendelian randomization study on the effect of 25‐hydroxyvitamin D levels on periodontitis by Baumeister, Sebastian‐Edgar, Reckelkamm, Stefan Lars, Baurecht, Hansjörg, Nolde, Michael, Kocher, Thomas, Holtfreter, Birte, Ehmke, Benjamin, Hannemann, Anke

“…Background Twenty five‐hydroxy vitamin D (25OHD) levels have been proposed to protect against periodontitis based on in vitro and observational studies but…”
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Physical activity and the risk of periodontitis: an instrumental variable study by Baumeister, Sebastian-Edgar, Reckelkamm, Stefan Lars, Ehmke, Benjamin, Nolde, Michael, Baurecht, Hansjörg

“…Objectives Observational studies suggested an inverse association between physical activity and periodontitis. However, observational studies might be subject…”
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Complement C3 as a potential drug target in periodontitis: Evidence from the cis‐Mendelian randomization approach by Alayash, Zoheir, Baumeister, Sebastian‐Edgar, Holtfreter, Birte, Kocher, Thomas, Baurecht, Hansjörg, Ehmke, Benjamin, Nolde, Michael, Reckelkamm, Stefan Lars

“…Aim Evidence from a Phase IIa trial showed that a complement C3‐targeted drug reduced gingival inflammation in patients with gingivitis. Using drug‐target…”
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Optimizing a Diagnostic Model of Periodontitis by Using Targeted Proteomics by Reckelkamm, Stefan Lars, Kamińska, Inga, Baumeister, Sebastian-Edgar, Holtfreter, Birte, Alayash, Zoheir, Rodakowska, Ewa, Baginska, Joanna, Kamiński, Karol Adam, Nolde, Michael

“…Periodontitis (PD), a widespread chronic infectious disease, compromises oral health and is associated with various systemic conditions and hematological…”
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Genotype‐driven NPC1L1 and PCSK9 inhibition and reduced risk of periodontitis by Baumeister, Sebastian‐Edgar, Holtfreter, Birte, Reckelkamm, Stefan Lars, Kocher, Thomas, Alayash, Zoheir, Ehmke, Benjamin, Baurecht, Hansjörg, Nolde, Michael

“…Aim Epidemiological and pre‐clinical studies suggest a chemoprotective role of lipid‐lowering agents in periodontitis. We tested the association of genetically…”
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Association between bone turnover markers and periodontitis: A population‐based cross‐sectional study by Reckelkamm, Stefan Lars, Hannemann, Anke, Kocher, Thomas, Nauck, Matthias, Völzke, Henry, Ehmke, Benjamin, Rauner, Martina, Alayash, Zoheir, Baumeister, Sebastian‐Edgar, Nolde, Michael, Holtfreter, Birte

“…Aim To examine the associations between bone turnover markers and periodontitis in two cross‐sectional population‐based studies. Materials and Methods We used…”
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Cannabis use and the risk of periodontitis: A two‐sample Mendelian randomization study by Baumeister, Sebastian‐Edgar, Alayash, Zoheir, Baurecht, Hansjörg, Reckelkamm, Stefan Lars, Kocher, Thomas, Holtfreter, Birte, Ehmke, Benjamin, Nolde, Michael

“…Aim This study aimed to leverage human genetic data to investigate whether cannabis use causally affects periodontitis. Materials and Methods Data were…”
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Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis by Reckelkamm, Stefan Lars, Kamińska, Inga, Baumeister, Sebastian-Edgar, Ponce-de-Leon, Mariana, Ehmke, Benjamin, Rodakowska, Ewa, Baginska, Joanna, Nolde, Michael, Kamiński, Karol Adam

“…Objectives Periodontitis (PD) can cause systematic inflammation and is associated with various metabolic processes in the body. However, robust serum markers…”
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