Search Results - "Recio, Leslie"

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin by Hobbs, Cheryl A., Koyanagi, Mihoko, Swartz, Carol, Davis, Jeffrey, Maronpot, Robert, Recio, Leslie, Hayashi, Shim-mo

“…Gardenia blue is widely used in Eastern Asia as a natural food colorant. To evaluate the genotoxic potential of gardenia blue, as well as genipin, the natural…”
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Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin by Hobbs, Cheryl A., Swartz, Carol, Maronpot, Robert, Davis, Jeffrey, Recio, Leslie, Koyanagi, Mihoko, Hayashi, Shim-mo

“…Myricitrin, a flavonoid extracted from the fruit, leaves, and bark of Chinese bayberry (Myrica rubra SIEBOLD), is currently used as a flavor modifier in snack…”
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Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water by Moffat, Ivy, Chepelev, Nikolai L., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Williams, Andrew, Halappanavar, Sabina, Malik, Amal I, Luijten, Mirjam, Aubrecht, Jiri, Hyduke, Daniel R., Fornace, Albert J., Swartz, Carol D., Recio, Leslie, Yauk, Carole L.

“…Abstract Toxicogenomics is proposed to be a useful tool in human health risk assessment. However, a systematic comparison of traditional risk assessment…”
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Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD) by Webster, A Francina, Chepelev, Nikolai, Gagné, Rémi, Kuo, Byron, Recio, Leslie, Williams, Andrew, Yauk, Carole L

“…Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how…”
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Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential by Hobbs, Cheryl A., Koyanagi, Mihoko, Swartz, Carol, Davis, Jeffrey, Kasamoto, Sawako, Maronpot, Robert, Recio, Leslie, Hayashi, Shim-mo

“…Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as…”
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Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells by Buick, Julie K, Williams, Andrew, Gagné, Rémi, Swartz, Carol D, Recio, Leslie, Ferguson, Stephen S, Yauk, Carole L

“…Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards…”
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Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues by Webster, A Francina, Zumbo, Paul, Fostel, Jennifer, Gandara, Jorge, Hester, Susan D, Recio, Leslie, Williams, Andrew, Wood, Charles E, Yauk, Carole L, Mason, Christopher E

“…Formalin-fixed paraffin-embedded (FFPE) tissue samples represent a potentially invaluable resource for transcriptomic research. However, use of FFPE samples in…”
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Impact of Acrylamide on Calcium Signaling and Cytoskeletal Filaments in Testes From F344 Rat by Recio, Leslie, Friedman, Marvin, Marroni, Dennis, Maynor, Timothy, Chepelev, Nikolai L.

“…Acrylamide (AA) at high exposure levels is neurotoxic, induces testicular toxicity, and increases dominant lethal mutations in rats. RNA-sequencing in testes…”
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Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol by Recio, Leslie, Hobbs, Cheryl, Caspary, William, Witt, Kristine L.

“…The in vivo micronucleus (MN) assay has proven to be an effective measure of genotoxicity potential. However, sampling a single tissue (bone marrow) for a…”
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Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer by Chepelev, Nikolai L., Gagné, Rémi, Maynor, Timothy, Kuo, Byron, Hobbs, Cheryl A., Recio, Leslie, Yauk, Carole L.

“…Acrylamide (AA) exposure in 2-year cancer bioassays leads to thyroid, but not liver, adenomas and adenocarcinomas in rats. Hypothesized modes of action (MOAs)…”
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Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9 by Yauk, Carole L., Buick, Julie K., Williams, Andrew, Swartz, Carol D., Recio, Leslie, Li, Heng-Hong, Fornace Jr, Albert J., Thomson, Errol M., Aubrecht, Jiri

“…In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as…”
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A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures by Buick, Julie K., Williams, Andrew, Meier, Matthew J., Swartz, Carol D., Recio, Leslie, Gagné, Rémi, Ferguson, Stephen S., Engelward, Bevin P., Yauk, Carole L.

“…Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we…”
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Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure by Moeller, Benjamin C, Recio, Leslie, Green, Amanda, Sun, Wei, Wright, Fred A, Bodnar, Wanda M, Swenberg, James A

“…The dose-response relationship for biomarkers of exposure (N(2)-ethylidene-dG adducts) and effect (cell survival and micronucleus formation) was determined…”
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Comet assay evaluation of six chemicals of known genotoxic potential in rats by Hobbs, Cheryl A., Recio, Leslie, Streicker, Michael, Boyle, Molly H., Tanaka, Jin, Shiga, Atsushi, Witt, Kristine L.

“…•Five genotoxic carcinogens were tested for induction of DNA damage in rats.•Liver and stomach cells of exposed rats were analyzed using the comet assay.•Only…”
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Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice by Frawley, Rachel, DeVito, Michael, Walker, Nigel J, Birnbaum, Linda, White, Jr, Kimber, Smith, Matthew, Maynor, Timothy, Recio, Leslie, Germolec, Dori

“…The use of brominated flame retardants and incineration of bromine-containing materials has lead to an increase in polybrominated dibenzo-p-dioxins and…”
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Investigation of the Low-Dose Response in the In Vivo Induction of Micronuclei and Adducts by Acrylamide by Zeiger, Errol, Recio, Leslie, Fennell, Timothy R., Haseman, Joseph K., Snyder, Rodney W., Friedman, Marvin

“…Acrylamide is an industrial chemical used in polymer manufacture. It is also formed in foods processed at high temperatures. It induces chromosome aberrations…”
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Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues by Recio, Leslie, Kissling, Grace E., Hobbs, Cheryl A., Witt, Kristine L.

“…The National Toxicology Program (NTP) is using the Comet assay to evaluate genotoxic potential, and is investigating the integration of this assay into…”
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Evaluation of the genotoxicity of the food additive, gum ghatti by Hobbs, Cheryl A., Swartz, Carol, Maronpot, Robert, Davis, Jeffrey, Recio, Leslie, Hayashi, Shim-mo

“…► Consumers worldwide could benefit from expanded use of gum ghatti in food products. ► Gum ghatti was tested in a full battery of GLP compliant genotoxicity…”
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Gene expression analysis of livers from female B6C3F1 mice exposed to carcinogenic and non-carcinogenic doses of furan, with or without bromodeoxyuridine (BrdU) treatment by Webster, Anna Francina, Williams, Andrew, Recio, Leslie, Yauk, Carole L.

“…Standard methodology for identifying chemical carcinogens is both time-consuming and resource intensive. Researchers are actively investigating how new…”
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A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells by Williams, Andrew, Buick, Julie K., Moffat, Ivy, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng-Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.

“…Genotoxicity testing is a critical component of chemical assessment. The use of integrated approaches in genetic toxicology, including the incorporation of…”
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