Search Results - "Rebrin, Igor"

Pro-oxidant shift in glutathione redox state during aging by Rebrin, Igor, Sohal, Rajindar S.

“…The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an…”
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Effects of age and caloric restriction on glutathione redox state in mice by Rebrin, Igor, Kamzalov, Sergey, Sohal, Rajindar S

“…The main purpose of this study was to determine whether the aging process in the mouse is associated with a pro-oxidizing shift in the redox state of…”
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Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila by Radyuk, Svetlana N, Michalak, Katarzyna, Klichko, Vladimir I, Benes, Judith, Rebrin, Igor, Sohal, Rajindar S, Orr, William C

“…Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively…”
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Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster by Legan, Susan K., Rebrin, Igor, Mockett, Robin J., Radyuk, Svetlana N., Klichko, Vladimir I., Sohal, Rajindar S., Orr, William C.

“…The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement…”
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Association between life-span extension by caloric restriction and thiol redox state in two different strains of mice by Rebrin, Igor, Forster, Michael J., Sohal, Rajindar S.

“…The hypothesis that the life-extending effect of caloric restriction (CR) is associated with an attenuation of the age-related pro-oxidant shift in the thiol…”
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Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 mice by Rebrin, Igor, Forster, Michael J, Sohal, Rajindar S

“…Abstract The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative…”
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Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster by Ren, Jian-Ching, Rebrin, Igor, Klichko, Vladimir, Orr, William C., Sohal, Rajindar S.

“…► Cytochrome c oxidase loses catalytic activity during the aging process. ► Abundance of seven nuclear-encoded subunits of cytochrome c oxidase decreased with…”
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Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat by Kwong, Linda K, Kamzalov, Sergey, Rebrin, Igor, Bayne, Anne-Cécile V, Jana, Chandan K, Morris, Paul, Forster, Michael J, Sohal, Rajindar S

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A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior by Chen, Kevin, Holschneider, Daniel P., Wu, Weihua, Rebrin, Igor, Shih, Jean C.

“…A spontaneous monoamine oxidase A (MAO A) mutation (A863T) in exon 8 introduced a premature stop codon, which produced MAO A/B double knock-out (KO) mice in a…”
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Overexpression of Glutamate-Cysteine Ligase Extends Life Span in Drosophila melanogaster by Orr, William C., Radyuk, Svetlana N., Prabhudesai, Leena, Toroser, Dikran, Benes, Judith J., Luchak, James M., Mockett, Robin J., Rebrin, Igor, Hubbard, J. Gregory, Sohal, Rajindar S.

“…The hypothesis that overexpression of glutamate-cysteine ligase (GCL), which catalyzes the rate-limiting reaction in de novo glutathione biosynthesis, could…”
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Effects of age and calorie restriction on tryptophan nitration, protein content, and activity of succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondria by Brégère, Catherine, Rebrin, Igor, Gallaher, Timothy K., Sohal, Rajindar S.

“…This study examined the protein targets of nitration and the consequent impact on protein function in rat kidney mitochondria at 4, 13, 19, and 24 months of…”
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Nitration of Tryptophan 372 in Succinyl-CoA:3-Ketoacid CoA Transferase during Aging in Rat Heart Mitochondria by Rebrin, Igor, Brégère, Catherine, Kamzalov, Sergey, Gallaher, Timothy K, Sohal, Rajindar S

“…The main objective of this study was to test the hypothesis that in vivo post-translational modifications in proteins, induced by the endogenously generated…”
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Substrate and Inhibitor Specificities for Human Monoamine Oxidase A and B Are Influenced by a Single Amino Acid by Geha, Rani Maurice, Rebrin, Igor, Chen, Kevin, Shih, Jean Chen

“…Monoamine oxidase (MAO) is responsible for the oxidation of biogenic and dietary amines. It exists as two isoforms, A and B, which have a 70% amino acid…”
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Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouse by Rebrin, Igor, Zicker, Steven, Wedekind, Karen J, Paetau-Robinson, Inke, Packer, Lester, Sohal, Rajindar S

“…The main purpose of this study was to investigate whether consumption of diets enriched in antioxidants attenuates the level of oxidative stress in the…”
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Forebrain-specific Expression of Monoamine Oxidase A Reduces Neurotransmitter Levels, Restores the Brain Structure, and Rescues Aggressive Behavior in Monoamine Oxidase A-deficient Mice by Chen, Kevin, Cases, Olivier, Rebrin, Igor, Wu, Weihua, Gallaher, Timothy K., Seif, Isabelle, Shih, Jean Chen

“…Previous studies have established that abrogation of monoamine oxidase (MAO) A expression leads to a neurochemical, morphological, and behavioral specific…”
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Detection and characterization of peroxynitrite-induced modifications of tyrosine, tryptophan, and methionine residues by tandem mass spectrometry by Rebrin, Igor, Bregere, Catherine, Gallaher, Timothy K, Sohal, Rajindar S

“…Nitration and oxidation of tyrosine, tryptophan, and methionine residues in proteins are potential markers of their interaction with peroxynitrite. This…”
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The Catalytic Subunit of Drosophila Glutamate-Cysteine Ligase Is a Nucleocytoplasmic Shuttling Protein by Radyuk, Svetlana N., Rebrin, Igor, Luchak, James M., Michalak, Katarzyna, Klichko, Vladimir I., Sohal, Rajindar S., Orr, William C.

“…GSH concentration is considerably lower in the nucleus than in the cytoplasm; however, it is significantly elevated during active cell proliferation. The main…”
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Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria by Radyuk, Svetlana N., Michalak, Katarzyna, Rebrin, Igor, Sohal, Rajindar S., Orr, William C.

“…The main purpose of this study was to determine whether enhancement of repair capacity would attenuate mitochondrial DNA oxidative damage and result in greater…”
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Effects of Carboxyl-terminal Truncations on the Activity and Solubility of Human Monoamine Oxidase B by Rebrin, I, Geha, R M, Chen, K, Shih, J C

“…Monoamine oxidase is an outer mitochondrial membrane protein that catalyzes the deamination of a number of neurotransmitters and dietary amines. To determine…”
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Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice by Sohal, Rajindar S., Kamzalov, Sergey, Sumien, Nathalie, Ferguson, Melissa, Rebrin, Igor, Heinrich, Kevin R., Forster, Michael J.

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