Search Results - "Reboul, F."

A Stochastic Hill Climbing Approach for Simultaneous 2D Alignment and Clustering of Cryogenic Electron Microscopy Images by Reboul, Cyril F., Bonnet, Frederic, Elmlund, Dominika, Elmlund, Hans

“…A critical step in the analysis of novel cryogenic electron microscopy (cryo-EM) single-particle datasets is the identification of homogeneous subsets of…”
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Method for 3D atomic structure determination of multi-element nanoparticles with graphene liquid-cell TEM by Heo, Junyoung, Kim, Dongjun, Choi, Hyesung, Kim, Sungin, Chun, Hoje, Reboul, Cyril F., Van, Cong T. S., Elmlund, Dominika, Choi, Soonmi, Kim, Kihyun, Park, Younggil, Elmlund, Hans, Han, Byungchan, Park, Jungwon

“…Determining the 3D atomic structures of multi-element nanoparticles in their native liquid environment is crucial to understanding their physicochemical…”
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Structure of the poly-C9 component of the complement membrane attack complex by Dudkina, Natalya V., Spicer, Bradley A., Reboul, Cyril F., Conroy, Paul J., Lukoyanova, Natalya, Elmlund, Hans, Law, Ruby H. P., Ekkel, Susan M., Kondos, Stephanie C., Goode, Robert J. A., Ramm, Georg, Whisstock, James C., Saibil, Helen R., Dunstone, Michelle A.

“…The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is the major component of the MAC, a multi-protein complex that forms pores…”
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Conformational changes during pore formation by the perforin-related protein pleurotolysin by Lukoyanova, Natalya, Kondos, Stephanie C, Farabella, Irene, Law, Ruby H P, Reboul, Cyril F, Caradoc-Davies, Tom T, Spicer, Bradley A, Kleifeld, Oded, Traore, Daouda A K, Ekkel, Susan M, Voskoboinik, Ilia, Trapani, Joseph A, Hatfaludi, Tamas, Oliver, Katherine, Hotze, Eileen M, Tweten, Rodney K, Whisstock, James C, Topf, Maya, Saibil, Helen R, Dunstone, Michelle A

“…Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and…”
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A new model for pore formation by cholesterol-dependent cytolysins by Reboul, Cyril F, Whisstock, James C, Dunstone, Michelle A

“…Cholesterol Dependent Cytolysins (CDCs) are important bacterial virulence factors that form large (200-300 Å) membrane embedded pores in target cells…”
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Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin by Leung, Carl, Dudkina, Natalya V, Lukoyanova, Natalya, Hodel, Adrian W, Farabella, Irene, Pandurangan, Arun P, Jahan, Nasrin, Pires Damaso, Mafalda, Osmanović, Dino, Reboul, Cyril F, Dunstone, Michelle A, Andrew, Peter W, Lonnen, Rana, Topf, Maya, Saibil, Helen R, Hoogenboom, Bart W

“…Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as…”
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Stonefish toxin defines an ancient branch of the perforin-like superfamily by Ellisdon, Andrew M., Reboul, Cyril F., Panjikar, Santosh, Huynh, Kitmun, Oellig, Christine A., Winter, Kelly L., Dunstone, Michelle A., Hodgson, Wayne C., Seymour, Jamie, Dearden, Peter K., Tweten, Rodney K., Whisstock, James C., McGowan, Sheena

“…The lethal factor in stonefish venom is stonustoxin (SNTX), a heterodimeric cytolytic protein that induces cardiovascular collapse in humans and native…”
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Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex by Reboul, Cyril F, Meyer, Grischa R, Porebski, Benjamin T, Borg, Natalie A, Buckle, Ashley M

“…The crystal structures of unliganded and liganded pMHC molecules provide a structural basis for TCR recognition yet they represent 'snapshots' and offer…”
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X-ray crystal structure of the streptococcal specific phage lysin PlyC by McGowan, Sheena, Buckle, Ashley M, Mitchell, Michael S, Hoopes, James T, Gallagher, D. Travis, Heselpoth, Ryan D, Shen, Yang, Reboul, Cyril F, Law, Ruby H. P, Fischetti, Vincent A, Whisstock, James C, Nelson, Daniel C

“…Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress from the host. When applied exogenously, these enzymes destroy…”
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SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time by Caesar, Joseph, Reboul, Cyril F., Machello, Chiara, Kiesewetter, Simon, Tang, Molly L., Deme, Justin C., Johnson, Steven, Elmlund, Dominika, Lea, Susan M., Elmlund, Hans

“…[Display omitted] We here introduce the third major release of the SIMPLE (Single-particle IMage Processing Linux Engine) open-source software package for…”
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Ethical issues in innovative research in pediatrics by Momboisse, F., Reboul Salze, F., Portefaix, A., Aubert-Fourmy, C., Vergely, C., Zucker, J.-M.

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Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network by Swedberg, Joakim E, de Veer, Simon J, Sit, Kei C, Reboul, Cyril F, Buckle, Ashley M, Harris, Jonathan M

“…Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s)…”
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Crystallographic and molecular dynamics analysis of loop motions unmasking the peptidoglycan-binding site in stator protein MotB of flagellar motor by Reboul, Cyril F, Andrews, Daniel A, Nahar, Musammat F, Buckle, Ashley M, Roujeinikova, Anna

“…The C-terminal domain of MotB (MotB-C) shows high sequence similarity to outer membrane protein A and related peptidoglycan (PG)-binding proteins. It is…”
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Small, solubilized platinum nanocrystals consist of an ordered core surrounded by mobile surface atoms by Wietfeldt, Henry, Meana-Pañeda, Rubén, Machello, Chiara, Reboul, Cyril F., Van, Cong T. S., Kim, Sungin, Heo, Junyoung, Kim, Byung Hyo, Kang, Sungsu, Ercius, Peter, Park, Jungwon, Elmlund, Hans

“…In situ structures of Platinum (Pt) nanoparticles (NPs) can be determined with graphene liquid cell transmission electron microscopy. Atomic-scale…”
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Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis by Kass, Itamar, Hoke, David E, Costa, Mauricio G S, Reboul, Cyril F, Porebski, Benjamin T, Cowieson, Nathan P, Leh, Hervé, Pennacchietti, Eugenia, McCoey, Julia, Kleifeld, Oded, Borri Voltattorni, Carla, Langley, David, Roome, Brendan, Mackay, Ian R, Christ, Daniel, Perahia, David, Buckle, Malcolm, Paiardini, Alessandro, De Biase, Daniela, Buckle, Ashley M

“…The human neuroendocrine enzyme glutamate decarboxylase (GAD) catalyses the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) using…”
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Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine by Atkinson, Sarah C, Dogovski, Con, Downton, Matthew T, Pearce, F Grant, Reboul, Cyril F, Buckle, Ashley M, Gerrard, Juliet A, Dobson, Renwick C J, Wagner, John, Perugini, Matthew A

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the rate limiting step in lysine biosynthesis in bacteria and plants. The structure of DHDPS has been determined…”
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Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC by Riley, Blake T, Broendum, Sebastian S, Reboul, Cyril F, Cowieson, Nathan P, Costa, Mauricio G S, Kass, Itamar, Jackson, Colin, Perahia, David, Buckle, Ashley M, McGowan, Sheena

“…The growing problem of antibiotic resistance underlies the critical need to develop new treatments to prevent and control resistant bacterial infection…”
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MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography by Konagurthu, Arun S, Reboul, Cyril F, Schmidberger, Jason W, Irving, James A, Lesk, Arthur M, Stuckey, Peter J, Whisstock, James C, Buckle, Ashley M

“…A central tenet of structural biology is that related proteins of common function share structural similarity. This has key practical consequences for the…”
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Single‐particle cryo‐EM—Improved ab initio 3D reconstruction with SIMPLE/PRIME by Reboul, Cyril F., Eager, Michael, Elmlund, Dominika, Elmlund, Hans

“…Cryogenic electron microscopy (cryo‐EM) and single‐particle analysis now enables the determination of high‐resolution structures of macromolecular assemblies…”
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Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution by Kim, Byung Hyo, Heo, Junyoung, Kim, Sungin, Reboul, Cyril F, Chun, Hoje, Kang, Dohun, Bae, Hyeonhu, Hyun, Hyejeong, Lim, Jongwoo, Lee, Hoonkyung, Han, Byungchan, Hyeon, Taeghwan, Alivisatos, A Paul, Ercius, Peter, Elmlund, Hans, Park, Jungwon

“…Precise three-dimensional (3D) atomic structure determination of individual nanocrystals is a prerequisite for understanding and predicting their physical…”
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