Search Results - "Rebolledo, Daniela L"

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers by Gonzalez, David, Contreras, Osvaldo, Rebolledo, Daniela L, Espinoza, Juan Pablo, van Zundert, Brigitte, Brandan, Enrique

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis…”
Get full text

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis by Contreras, Osvaldo, Rebolledo, Daniela L., Oyarzún, Juan Esteban, Olguín, Hugo C., Brandan, Enrique

“…Fibrosis occurs in skeletal muscle under various pathophysiological conditions such as Duchenne muscular dystrophy (DMD), a devastating disease characterized…”
Get full text

Role of Matricellular CCN Proteins in Skeletal Muscle: Focus on CCN2/CTGF and Its Regulation by Vasoactive Peptides by Rebolledo, Daniela L, Acuña, María José, Brandan, Enrique

“…The Cellular Communication Network (CCN) family of matricellular proteins comprises six proteins that share conserved structural features and play numerous…”
Get full text

The functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance by Caceres-Ayala, Constanza, Pautassi, Ricardo M., Acuña, María José, Cerpa, Waldo, Rebolledo, Daniela L.

“…Background: Chronic alcohol misuse is associated with alcoholic myopathy, characterized by skeletal muscle weakness and atrophy. Moreover, there is evidence…”
Get full text

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission by Mira, Rodrigo G, Lira, Matias, Tapia-Rojas, Cheril, Rebolledo, Daniela L, Quintanilla, Rodrigo A, Cerpa, Waldo

“…Problematic alcohol drinking and alcohol dependence are an increasing health problem worldwide. Alcohol abuse is responsible for approximately 5% of the total…”
Get full text

Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats by Cáceres-Ayala, Constanza, Mira, Rodrigo G, Acuña, María José, Brandan, Enrique, Cerpa, Waldo, Rebolledo, Daniela L

“…Binge Drinking (BD) corresponds to episodes of ingestion of large amounts of ethanol in a short time, typically ≤2 h. BD occurs across all populations, but…”
Get full text

Denervation Drives YAP/TAZ Activation in Muscular Fibro/Adipogenic Progenitors by Gallardo, Felipe S, Córdova-Casanova, Adriana, Bock-Pereda, Alexia, Rebolledo, Daniela L, Ravasio, Andrea, Casar, Juan Carlos, Brandan, Enrique

“…Loss of motoneuron innervation (denervation) is a hallmark of neurodegeneration and aging of the skeletal muscle. Denervation induces fibrosis, a response…”
Get full text

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury by Fuentes‐Flores, Andrés, Geronimo‐Olvera, Cristian, Girardi, Karina, Necuñir‐Ibarra, David, Patel, Sandip Kumar, Bons, Joanna, Wright, Megan C, Geschwind, Daniel, Hoke, Ahmet, Gomez‐Sanchez, Jose A, Schilling, Birgit, Rebolledo, Daniela L, Campisi, Judith, Court, Felipe A

“…Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a…”
Get full text

Driving fibrosis in neuromuscular diseases: Role and regulation of Connective tissue growth factor (CCN2/CTGF) by Rebolledo, Daniela L., Lipson, Kenneth E., Brandan, Enrique

“…Connective tissue growth factor or cellular communication network 2 (CCN2/CTGF) is a matricellular protein member of the CCN family involved in several crucial…”
Get full text

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers by Valle-Tenney, Roger, Rebolledo, Daniela L., Lipson, Kenneth E., Brandan, Enrique

“…Several skeletal muscle diseases are characterized by fibrosis, the excessive accumulation of extracellular matrix. Transforming growth factor-β (TGF-β) and…”
Get full text

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β by Rebolledo, Daniela L., González, David, Faundez-Contreras, Jennifer, Contreras, Osvaldo, Vio, Carlos P., Murphy-Ullrich, Joanne E., Lipson, Kenneth E., Brandan, Enrique

“…Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that replaces functional tissue, and it is a feature of several myopathies…”
Get full text

The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model by Gonzalez, David, Rebolledo, Daniela L, Correa, Lina M, Court, Felipe A, Cerpa, Waldo, Lipson, Kenneth E, van Zundert, Brigitte, Brandan, Enrique

“…Abstract Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset progressive neurodegenerative disease characterized by upper and lower motoneuron…”
Get full text

Sarcolemmal targeting of nNOSμ improves contractile function of mdx muscle by Rebolledo, Daniela L, Kim, Min Jeong, Whitehead, Nicholas P, Adams, Marvin E, Froehner, Stanley C

“…Nitric oxide (NO) is a key regulator of skeletal muscle function and metabolism, including vasoregulation, mitochondrial function, glucose uptake, fatigue and…”
Get full text

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification by Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C

“…Abstract Background The amyloid β-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic…”
Get full text

Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis by Rebolledo, Daniela L, Aldunate, Rebeca, Kohn, Rebecca, Neira, Iván, Minniti, Alicia N, Inestrosa, Nibaldo C

“…Alzheimer's disease and inclusion body myositis (IBM) are disorders frequently found in the elderly and characterized by the presence of amyloid-β peptide (Aβ)…”
Get full text

Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle by Rebolledo, Daniela L., Minniti, Alicia N., Grez, Paula M., Fadic, Ricardo, Kohn, Rebecca, Inestrosa, Nibaldo C.

“…Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not…”
Get full text

ALS skeletal muscle shows enhanced TGF-[beta] signaling, fibrosis and induction of fibro/adipogenic progenitor markers by Gonzalez, David, Contreras, Osvaldo, Rebolledo, Daniela L, Espinoza, Juan Pablo, van Zundert, Brigitte, Brandan, Enrique

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis…”
Get full text

Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification by Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C

“…The amyloid beta-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The…”
Get full text