Search Results - "Rebernik, Patrick"
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A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
Published in Nature communications (08-10-2022)“…The lateral septum (LS) has been implicated in the regulation of locomotion. Nevertheless, the neurons synchronizing LS activity with the brain’s clock in the…”
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NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds
Published in Bioorganic & medicinal chemistry (01-05-2009)“…Open-chain analogues of the prominent NMDA channel blocker MK-801 exhibit a high degree of stereoselectivity, inhibiting the binding of [ 3H]MK-801 to rat…”
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3
New polyamine-sensitive inhibitors of the NMDA receptor: Syntheses and pharmacological evaluation
Published in European journal of medicinal chemistry (01-02-2007)“…Derivatives of 5-(4-aminobutyl)-2-thiophene-octylamine, a potent polyamine-sensitive inhibitor of the NMDA receptor, were synthesized and evaluated as…”
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4
Molecular design of hypothalamus development
Published in Nature (London) (01-06-2020)“…A wealth of specialized neuroendocrine command systems intercalated within the hypothalamus control the most fundamental physiological needs in vertebrates 1 ,…”
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5
Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers
Published in Bioorganic & medicinal chemistry letters (01-10-2015)“…[Display omitted] The specific binding of the NMDA receptor (NR) channel ligand [3H]MK-801 to rat brain membranes is sensitive to positively charged buffer…”
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6
The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine
Published in Neuropharmacology (01-03-2012)“…Amantadine is an established antiparkinsonian drug with a still unclear molecular site of action. In vivo studies on rodents, in vitro studies on tissue of…”
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7
Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner
Published in Neuropharmacology (01-02-2009)“…The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic…”
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Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors
Published in Bioorganic & medicinal chemistry (01-08-2015)“…[Display omitted] The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological…”
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Exploring the Polyamine Regulatory Site of the NMDA Receptor: a Parallel Synthesis Approach
Published in ChemMedChem (01-01-2013)“…The elongated structures of polyamine inverse agonists such as 1,12‐diaminododecane (N12N) and 5‐(4‐aminobutyl)‐2‐thiopheneoctanamine (N4T8N) lend themselves…”
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10
Zn2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release
Published in Neuropharmacology (01-02-2004)“…The psychostimulant drug amphetamine increases extracellular monamines in the brain acting on neurotransmitter transporters, especially the dopamine…”
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11
Zn 2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release
Published in Neuropharmacology (2004)“…The psychostimulant drug amphetamine increases extracellular monamines in the brain acting on neurotransmitter transporters, especially the dopamine…”
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12
Polyamines and the NMDA receptor: Modifying intrinsic activities with aromatic substituents
Published in Bioorganic & medicinal chemistry letters (01-06-2006)“…The inhibiting effects of 34 spermidine and spermine derivatives on the binding of [ 3H]MK-801 to NMDA receptors on rat brain membranes were investigated…”
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13
Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex
Published in The Journal of pharmacology and experimental therapeutics (01-06-1999)“…In this study, we investigated the hypothesis that inhibition of the N-methyl-D-aspartate (NMDA) receptor complex by zinc involves a polyamine-sensitive…”
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14
Aminooxy-analogues of spermidine: new partial agonists and antagonists at the polyamine site of the rat hippocampal NMDA receptor complex
Published in Neuroscience letters (12-01-1996)“…The amino-1-oxy- and amino-8-oxy-analogues of spermidine (1-O-SPD and 8-O-SPD) were tested in vitro with rat hippocampal membranes as potential modulators of…”
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