One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis
•Both AgP forms have similar clinical and immunological responses.•Periodontal treatment reduces the high pro-inflammatory ratio at GCF and serum.•GAgP and LAgP present poor serum level of cell transmigration mediators.•Only LAgP patients present elevated serum levels of CXCL8 at baseline. The local...
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| Published in: | Cytokine (Philadelphia, Pa.) Vol. 116; pp. 27 - 37 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01-04-2019
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | •Both AgP forms have similar clinical and immunological responses.•Periodontal treatment reduces the high pro-inflammatory ratio at GCF and serum.•GAgP and LAgP present poor serum level of cell transmigration mediators.•Only LAgP patients present elevated serum levels of CXCL8 at baseline.
The local and systemic immunological profiles of important inflammatory mediators in the localized (LAgP) and generalized (GAgP) forms of aggressive periodontitis are still unknown, as well as the effect of periodontal therapy on these parameters. The aim of this prospective study was to evaluate clinical and immune responses of patients with AgP undergoing nonsurgical treatment.
Eighteen patients with GAgP, 10 with LAgP and 10 healthy participants were included in this study. AgP participants were submitted to scaling and root planing plus systemic antibiotics (amoxicillin and metronidazole). At baseline and 1-year follow-up were measured clinical parameters, such as probing depth [PD] and clinical attachment loss [CAL], and the levels of 10 immunological mediators (GM-CSF, M-CSF, MCP-1, ICAM-1, CXCL8, IL-1β, TNF-α, IL-17, IL-4, and IL-10) in the gingival crevicular fluid (GCF) of selected sites [AgP forms: PD ≥ 6 mm or the deepest, bleeding on probing (BoP) and bone loss measured by periapical radiography; healthy individuals: PD ≤ 3 mm, no BoP, no bone loss] and serum.
After periodontal treatment both forms of AgP presented a significant reduction of PD and CAL, an increase of GM-CSF, ICAM-1, MCP-1, TNF-α, IL-17, IL-4, and IL-10 in the GCF, as well as of GM-CSF and IL-4 in the serum, and a reduction in the serum concentration of IL-1β. Serum levels of M-CSF, ICAM-1, and MCP-1 remained significantly below those found in healthy individuals in both forms of AgP even after therapy. An increase in the systemic or local levels of MCP-1, ICAM-1 and the anti-inflammatory profile (IL-4, IL-10) was correlated with an improvement in clinical parameters of LAgP patients. Also, a local reduction of IL-1β levels in both forms of AgP was correlated with an increase in the clinical attachment gain.
Nonsurgical periodontal therapy was successful in improving clinical parameters and modulating the immune response in both forms of AgP. However, this therapeutic approach does not seem to affect the deficient level of important serum mediators involved in mechanisms of cell transmigration. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1043-4666 1096-0023 |
| DOI: | 10.1016/j.cyto.2018.12.019 |