Search Results - "Rebeck, G W"

Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation by Trotter, J.H, Lussier, A.L, Psilos, K.E, Mahoney, H.L, Sponaugle, A.E, Hoe, H.-S, Rebeck, G.W, Weeber, E.J

“…Highlights • Reelin is important in adult synaptic plasticity and learning and memory. • How reelin is regulated remains to be elucidated. • tPA KO mice do not…”
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The Endocytic Receptor Protein LRP Also Mediates Neuronal Calcium Signaling via N-methyl-D-aspartate Receptors by Bacskai, B. J., Xia, M. Q., Strickland, D. K., Rebeck, G. W., Hyman, B. T.

“…The low density lipoprotein receptor-related protein (LRP) is an endocytic receptor that is a member of the low density lipoprotein receptor family. We report…”
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ApoE isoforms affect neuronal N-methyl- d-aspartate calcium responses and toxicity via receptor-mediated processes by Qiu, Z, Crutcher, K.A, Hyman, B.T, Rebeck, G.W

“…Apolipoprotein E (apoE) alters the pathophysiology of Alzheimer's disease, but its mechanism is not fully understood. We examined the effects of recombinant…”
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Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model by Khandelwal, Preeti J, Dumanis, Sonya B, Feng, Li Rebekah, Maguire-Zeiss, Kathleen, Rebeck, Gw, Lashuel, Hilal A, Moussa, Charbel Eh

“…α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies",…”
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Association of apolipoprotein E ε2 and vasculopathy in cerebral amyloid angiopathy by GREENBERG, S. M, VONSATTEL, J.-P. G, SEGAL, A. Z, CHIU, R. I, CLATWORTHY, A. E, LIAO, A, HYMAN, B. T, REBECK, G. W

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APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome by LAI, F, KAMMANN, E, REBECK, G. W, ANDERSON, A, CHEN, Y, NIXON, R. A

“…Alzheimer disease (AD) neuropathology is present in Down syndrome (DS) after age 35, but dementia onset varies from ages 40 to 70 years. Because of small…”
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Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation by GREENBERG, S. M, SHIN, Y, GRABOWSKI, T. J, COOPER, G. E, REBECK, G. W, IGLESIAS, S, CHAPON, F, TOURNIER-LASSERVE, E, BARON, J.-C

“…The authors searched for mutations in the beta-amyloid precursor protein in a Spanish family with a hereditary syndrome of hemorrhagic stroke, dementia,…”
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Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions by Rebeck, G W, Reiter, J S, Strickland, D K, Hyman, B T

“…An increased prevalence of apolipoprotein E (ApoE) epsilon 4 allele exists in late onset familial Alzheimer's disease. We found, in sporadic Alzheimer's…”
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Quantitative Analysis of Senile Plaques in Alzheimer Disease: Observation of Log-Normal Size Distribution and Molecular Epidemiology of Differences Associated with Apolipoprotein E Genotype and Trisomy 21 (Down Syndrome) by Hyman, B. T., West, H. L., Rebeck, G. W., Buldyrev, S. V., Mantegna, R. N., Ukleja, M., Havlin, S., Stanley, H. E.

“…The discovery that the ε4 allele of the apolipoprotein E (apoE) gene is a putative risk factor for Alzheimer disease (AD) in the general population has…”
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Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage by Berezovska, O, Jack, C, Deng, A, Gastineau, N, Rebeck, G W, Hyman, B T

“…Proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretases results in the production of a highly amyloidogenic Abeta peptide,…”
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Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase by REBECK, G. W, SAMSON, L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression and alternate splicing of apolipoprotein E receptor 2 in brain by Clatworthy, A.E., Stockinger, W., Christie, R.H., Schneider, W.J., Nimpf, J., Hyman, B.T., Rebeck, G.W.

“…Apolipoprotein E isoforms affect the risk of developing Alzheimer's disease. Apolipoprotein E-associated risk may be related to its binding to and clearance by…”
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Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease by HOLLENBACH, E, ACKERMANN, S, HYMAN, B. T, REBECK, G. W

“…C766T, a polymorphism in exon 3 of the gene for the low-density lipoprotein receptor-related protein (LRP), was found to be associated with late-onset…”
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Alzheimer's disease with and without coexisting Parkinson's disease changes : apolipoprotein E genotype and neuropathologic correlates by GEARING, M, SCHNEIDER, J. A, REBECK, G. W, HYMAN, B. T, MIRRA, S. S

“…The frequency of the apolipoprotein E (ApoE) epsilon 4 allele and its relationship with coexistent Parkinson's disease (PD) neuropathology in Alzheimer's…”
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Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease by Gearing, M, Rebeck, G W, Hyman, B T, Tigges, J, Mirra, S S

“…Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and…”
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Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background by IRIZARRY, M. C., REBECK, G. W., CHEUNG, B., BALES, K., PAUL, S. M, HOLZMAN, D., HYMAN, B. T.

“…: Several lines of evidence implicate apolipoprotein E (apoE) and its receptor‐the low density lipoprotein receptor related protein (LRP)‐in Alzheimer's…”
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Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator by Wang, Xiaoying, Lo, Eng H, Lee, Sun-Ryung, Arai, Ken, Lee, Seong-Ryong, Tsuji, Kiyoshi, Rebeck, G William

“…Although thrombolysis with tissue plasminogen activator (tPA) is a stroke therapy approved by the US Food and Drug Administration, its efficacy may be limited…”
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Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys by Poduri, A, Gearing, M, Rebeck, GW, Mirra, SS, Tigges, J, Hyman, BT

“…Recent studies of late onset familial and sporadic Alzheimer's disease (AD) show a genetic disequilibrium between inheritance of the epsilon 4 allele of the…”
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Expression of the Very Low-Density Lipoprotein Receptor (VLDL-r), an Apolipoprotein-E Receptor, in the Central Nervous System and in Alzheimerʼs Disease by Christie, Richard H, Chung, Haeyong, Rebeck, G William, Strickland, Dudley, Hyman, Bradley T

“…The very low density lipoprotein receptor (VLDL-r) is a cell-surface molecule specialized for the internalization of multiple diverse ligands, including…”
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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy by Grabowski, Thomas J., Cho, Hyun Soon, Vonsattel, Jean Paul G., Rebeck, G. William, Greenberg, Steven M.

“…Several mutations in the amyloid precursor protein (APP) gene have been found to associate with pathologic deposition of the β‐amyloid peptide (Aβ) in neuritic…”
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