Search Results - "Reaves, B."

Monocarboxylate Transporter 8 in Neuronal Cell Growth by James, S. R, Franklyn, J. A, Reaves, B. J, Smith, V. E, Chan, S. Y, Barrett, T. G, Kilby, M. D, McCabe, C. J

“…Thyroid hormones are essential for the normal growth and development of the fetus, and even small alterations in maternal thyroid hormone status during early…”
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The TRP channel superfamily: insights into how structure, protein-lipid interactions and localization influence function by Reaves, B J, Wolstenholme, A J

“…TRP (transient receptor potential) cationic channels are key molecules that are involved in a variety of diverse biological processes ranging from fertility to…”
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Perturbation of the Morphology of the Trans-Golgi Network Following Brefeldin A Treatment: Redistribution of a TGN-Specific Integral Membrane Protein, TGN38 by Reaves, Barbara, Banting, George

“…Brefeldin A (BFA) has a dramatic effect on the morphology of the Golgi apparatus and induces a rapid redistribution of Golgi proteins into the ER. To date, no…”
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Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization by Whitley, Paul, Reaves, Barbara J., Hashimoto, Makoto, Riley, Andrew M., Potter, Barry V.L., Holman, Geoffrey D.

“…Phosphatidylinositol 3,5-bisphosphate is a membrane lipid found in all eukaryotes so far studied but downstream effector proteins of this lipid have yet to be…”
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Comparison of initial warfarin response in obese patients versus non-obese patients by Wallace, Jessica L., Reaves, Anne B., Tolley, Elizabeth A., Oliphant, Carrie S., Hutchison, Lydia, Alabdan, Numan Abdulraman, Sands, Christopher W., Self, Timothy H.

“…Achieving therapeutic anticoagulation with warfarin is complicated by substantial inter-patient and intra-patient variability with numerous factors known to…”
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TGN38/41 recycles between the cell surface and the TGN : brefeldin A affects its rate of return to the TGN by REAVES, B, HORN, M, BANTING, G

“…TGN38 and TGN41 are isoforms of an integral membrane protein (TGN38/41) that is predominantly localized to the trans-Golgi network (TGN) of normal rat kidney…”
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Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles by Bright, N A, Reaves, B J, Mullock, B M, Luzio, J P

“…Electron microscopy was used to evaluate the function and formation of dense core lysosomes. Lysosomes were preloaded with bovine serum albumin (BSA)-gold…”
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Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients by March, Katherine L., Twilla, Jennifer D., Reaves, Anne B., Self, Timothy H., Slayton, Melissa M., Bergeron, Jaclyn B., Sakaan, Sami A.

“…Alcohol withdrawal syndrome (AWS) is a serious complication of abrupt alcohol cessation. Severe AWS can develop into delirium tremens (DT), which is…”
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Enzalutamide‐warfarin interaction necessitating warfarin dosage adjustment: A case report of successful clinical management by Parrett, J. L., Reaves, A. B., Self, T. H., Owens, R. E.

“…Summary What is known and objectives Enzalutamide package labeling recommends avoiding concurrent warfarin use due to potential reductions in warfarin…”
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Fever as a Risk Factor for Increased Response to Vitamin K Antagonists: A Review of the Evidence and Potential Mechanisms by Self, Timothy H, Oliphant, Carrie S, Reaves, Anne B, Richardson, Amy M, Sands, Christopher W

“…Abstract Numerous factors affect the response to vitamin K antagonists (VKA) including age, dietary vitamin K, other drugs, pharmacogenetics, and disease…”
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Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies by Reaves, B J, Row, P E, Bright, N A, Luzio, J P, Davidson, H W

“…A number of recent studies have highlighted the importance of lipid domains within endocytic organelles in the sorting and movement of integral membrane…”
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Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation by Row, P E, Reaves, B J, Domin, J, Luzio, J P, Davidson, H W

“…Lipid kinases and their phosphorylated products are important regulators of many cellular processes, including intracellular membrane traffic. The best example…”
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Risk of venous thromboembolism in hospitalized patients with peripherally inserted central catheters by Lobo, Bob L., Vaidean, Georgeta, Broyles, Joyce, Reaves, Anne B., Shorr, Ronald I.

“…BACKGROUND: Peripherally inserted central catheters (PICC) are increasingly used in hospitalized patients. The benefit can be offset by complications such as…”
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Supratherapeutic International Normalized Ratio Due to Reduced Vitamin K Intake Secondary to Prolonged Vomiting in a Patient on Warfarin by Reaves, Anne B, Clarke, Catherine J, Tillman, Emma M

“…OBJECTIVE: To report a case of prolonged vomiting during warfarin therapy, leading to an elevated international normalized ratio (INR). CASE SUMMARY: A…”
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The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway by Reaves, B J, Bright, N A, Mullock, B M, Luzio, J P

“…Addition of wortmannin to normal rat kidney cells caused a redistribution of the lysosomal type I integral membrane proteins Igp110 and Igp120 to a swollen…”
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Analysis of the co-localization of the insulin-responsive glucose transporter (GLUT4) and the trans Golgi network marker TGN38 within 3T3-L1 adipocytes by MARTIN, S, REAVES, B, BANTING, G, GOULD, G. W

“…The exposure of isolated adipocytes to insulin results in an approximately 20-fold increase in the rate of glucose transport into the cell. This increase is…”
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Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport by Rau, H, Reaves, B J, O'Rahilly, S, Whitehead, J P

“…We recently described a homozygous frameshift mutation in the human leptin (ob) gene associated with undetectable serum leptin and extreme obesity in two…”
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Underutilization of Aldosterone Antagonists in Heart Failure by Patterson, Shanise J., Reaves, Anne B., Tolley, Elizabeth A., Ulrich, Dagny, Hilty, Christopher, Clarke, Catherine J., Self, Timothy H.

“…Background: Treatment with an aldosterone antagonist (AA) has been shown in multiple trials to reduce heart failure (HF)–related morbidity, mortality, and…”
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Phosphoinositide 3-kinases and membrane traffic by Shepherd, Peter R., Reaves, Barbara J., Davidson, Howard W.

“…Phosphoinositide 3-kinases (PI 3-kinases) and their 3-phosphoinositide products were identified initially as components of intracellular signalling pathways…”
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Evaluation of antibiotic prescribing patterns in patients receiving sustained low-efficiency dialysis: opportunities for pharmacists by Harris, Laura E., Reaves, Anne B., Krauss, Amy G., Griner, Justin, Hudson, Joanna Q.

“…Objectives Sustained low‐efficiency dialysis (SLED) is a ‘hybrid’ form of continuous renal replacement therapy; however, there is very limited information on…”
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