Search Results - "Realini, Natalia"

A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration by Palese, Francesca, Pontis, Silvia, Realini, Natalia, Piomelli, Daniele

“…N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of membrane NAPEs into bioactive fatty-acid ethanolamides (FAEs). Along with…”
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Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus by Vozella, Valentina, Realini, Natalia, Misto, Alessandra, Piomelli, Daniele

“…Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P…”
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Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells by Lai, Michele, Realini, Natalia, La Ferla, Marco, Passalacqua, Ilaria, Matteoli, Giulia, Ganesan, Anand, Pistello, Mauro, Mazzanti, Chiara Maria, Piomelli, Daniele

“…Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers…”
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N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis by Pontis, Silvia, Palese, Francesca, Summa, Maria, Realini, Natalia, Lanfranco, Massimiliano, De Mei, Claudia, Piomelli, Daniele

“…[Display omitted] •NAAA terminates the biological actions of PEA, an endogenous PPAR-α agonist.•Spinal cord NAAA expression is enhanced in the EAE mouse model…”
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Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models by Sasso, Oscar, Moreno-Sanz, Guillermo, Martucci, Cataldo, Realini, Natalia, Dionisi, Mauro, Mengatto, Luisa, Duranti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertorelli, Rosalia, Reggiani, Angelo, Piomelli, Daniele

“…The N-acylethanolamine acid amidase inhibitor ARN077 exerts profound antinociceptive effects in animal pain models by enhancing endogenous lipid signaling at…”
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Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine by Greco, Rosaria, Demartini, Chiara, Zanaboni, Anna Maria, Francavilla, Miriam, Reggiani, Angelo, Realini, Natalia, Scarpelli, Rita, Piomelli, Daniele, Tassorelli, Cristina

“…Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors,…”
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Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis by Astarita, Giuseppe, Avanesian, Agnesa, Grimaldi, Benedetto, Realini, Natalia, Justinova, Zuzana, Panlilio, Leight V, Basit, Abdul, Goldberg, Steven R, Piomelli, Daniele

“…Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have…”
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Absolute nutrient concentration measurements in cell culture media: 1H q-NMR spectra and data to compare the efficiency of pH-controlled protein precipitation versus CPMG or post-processing filtering approaches by Goldoni, Luca, Beringhelli, Tiziana, Rocchia, Walter, Realini, Natalia, Piomelli, Daniele

“…The NMR spectra and data reported in this article refer to the research article titled “A simple and accurate protocol for absolute polar metabolite…”
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Cellular Mechanisms Underlying the Anxiolytic Effect of Low Doses of Peripheral Δ9-Tetrahydrocannabinol in Rats by Rubino, Tiziana, Sala, Mariaelvina, Viganò, Daniela, Braida, Daniela, Castiglioni, Chiara, Limonta, Valeria, Guidali, Cinzia, Realini, Natalia, Parolaro, Daniela

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Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION by Realini, Natalia, Palese, Francesca, Pizzirani, Daniela, Pontis, Silvia, Basit, Abdul, Bach, Anders, Ganesan, Anand, Piomelli, Daniele

“…Acid ceramidase (AC) is a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramides and concomitantly increasing…”
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Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats : Behavioral and Biochemical Correlates by RUBINO, Tiziana, VIGANO, Daniela, SALA, Mariaelvina, PAROLARO, Daniela, REALINI, Natalia, GUIDALI, Cinzia, BRAIDA, Daniela, CAPURRO, Valeria, CASTIGLIONI, Chiara, CHERUBINO, Francesca, ROMUALDI, Patrizia, CANDELETTI, Sanzio

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The endocannabinoid system and psychiatric disorders by Parolaro, Daniela, Realini, Natalia, Vigano, Daniela, Guidali, Cinzia, Rubino, Tiziana

“…The present review summarizes the latest information on the role and the pharmacological modulation of the endocannabinoid system in mood disorders and its…”
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Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity by Realini, Natalia, Solorzano, Carlos, Pagliuca, Chiara, Pizzirani, Daniela, Armirotti, Andrea, Luciani, Rosaria, Costi, Maria Paola, Bandiera, Tiziano, Piomelli, Daniele

“…The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high in several human tumors, which…”
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Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks by De Icco, Roberto, Greco, Rosaria, Demartini, Chiara, Vergobbi, Pietro, Zanaboni, Annamaria, Tumelero, Elena, Reggiani, Angelo, Realini, Natalia, Sances, Grazia, Grillo, Valentina, Allena, Marta, Tassorelli, Cristina

“…Migraine pathophysiology has been suggested to include dysregulation of the endocannabinoid system (ES). We simultaneously evaluated plasma anandamide (AEA)…”
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Chronic Δ -Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates

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Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood by Rubino, Tiziana, Realini, Natalia, Braida, Daniela, Guidi, Sandra, Capurro, Valeria, Viganò, Daniela, Guidali, Cinzia, Pinter, Marta, Sala, Mariaelvina, Bartesaghi, Renata, Parolaro, Daniela

“…Marijuana and hashish are the illicit drugs most frequently used by human adolescents. Given the continued neurodevelopment throughout adolescence, adolescents…”
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Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages by Zhu, Chenggang, Solorzano, Carlos, Sahar, Saurabh, Realini, Natalia, Fung, Ernest, Sassone-Corsi, Paolo, Piomelli, Daniele

“…Palmitoylethanolamide (PEA) is an endogenous lipid amide that modulates pain and inflammation by engaging peroxisome proliferator-activated receptor type-α…”
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Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism by Palese, Francesca, Pontis, Silvia, Realini, Natalia, Torrens, Alexa, Ahmed, Faizy, Assogna, Francesca, Pellicano, Clelia, Bossù, Paola, Spalletta, Gianfranco, Green, Kim, Piomelli, Daniele

“…The lysosomal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) deactivates palmitoylethanolamide (PEA), a lipid-derived PPAR-α agonist that is…”
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I18 Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease by Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Realini, Natalia, Scarselli, Pamela, Cicco, Clotilde Di, Armirotti, Andrea, Parlato, Rosanna, Pardo, Alba Di, Maglione, Vittorio

“…BackgroundOver the past few years our research has shown that alterations in sphingolipid metabolism represent a critical determinant in Huntington’s disease…”
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Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: Application to human subjects with neurodegenerative dementia by Armirotti, Andrea, Basit, Abdul, Realini, Natalia, Caltagirone, Carlo, Bossù, Paola, Spalletta, Gianfranco, Piomelli, Daniele

“…We describe a simple protocol for the preparation and orthogonal hydrophobic/hydrophilic LC–MS/MS analysis of mouse and human plasma samples, which enables the…”
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