Search Results - "Realini, Anthony"

The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma by Wiggs, Janey L, Hewitt, Alex W, Fan, Bao Jian, Wang, Dan Yi, Figueiredo Sena, Dayse R, O'Brien, Colm, Realini, Anthony, Craig, Jamie E, Dimasi, David P, Mackey, David A, Haines, Jonathan L, Pasquale, Louis R

“…Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and…”
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Corneal Hysteresis and Obstructive Sleep Apnea - Does It Account for Glaucoma? by Hadique, Sarah, MD, Mitchell, Kenneth, MD, Realini, Anthony, MD, Yow, Kim, RN, Curtis, Hilda, RN, Ghamande, Shekhar, MD

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Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma by Wiggs, Janey L, Yaspan, Brian L, Hauser, Michael A, Kang, Jae H, Allingham, R Rand, Olson, Lana M, Abdrabou, Wael, Fan, Bao J, Wang, Dan Y, Brodeur, Wendy, Budenz, Donald L, Caprioli, Joseph, Crenshaw, Andrew, Crooks, Kristy, Delbono, Elizabeth, Doheny, Kimberly F, Friedman, David S, Gaasterland, Douglas, Gaasterland, Terry, Laurie, Cathy, Lee, Richard K, Lichter, Paul R, Loomis, Stephanie, Liu, Yutao, Medeiros, Felipe A, McCarty, Cathy, Mirel, Daniel, Moroi, Sayoko E, Musch, David C, Realini, Anthony, Rozsa, Frank W, Schuman, Joel S, Scott, Kathleen, Singh, Kuldev, Stein, Joshua D, Trager, Edward H, Vanveldhuisen, Paul, Vollrath, Douglas, Wollstein, Gadi, Yoneyama, Sachiko, Zhang, Kang, Weinreb, Robert N, Ernst, Jason, Kellis, Manolis, Masuda, Tomohiro, Zack, Don, Richards, Julia E, Pericak-Vance, Margaret, Pasquale, Louis R, Haines, Jonathan L

“…Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more…”
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Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes by Aboobakar, Inas F., Kinzy, Tyler G., Zhao, Yan, Fan, Baojian, Pasquale, Louis R., Qassim, Ayub, Kolovos, Antonia, Schmidt, Joshua M., Craig, Jamie E., Cooke Bailey, Jessica N., Wiggs, Janey L., Allingham, R. Rand, Brilliant, Murray, Budenz, Donald L., Cooke Bailey, Jessica N., Fingert, John H., Gaasterland, Douglas, Gaasterland, Teresa, Haines, Jonathan L., Hauser, Michael A., Lee, Richard K., Lichter, Paul R., Liu, Yutao, Moroi, Syoko, Myers, Jonathan, Pasquale, Louis R., Pericak-Vance, Margaret, Realini, Anthony, Rhee, Doug, Richards, Julia E., Ritch, Robert, Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Weinreb, Robert N., Wiggs, Janey L., Wollstein, Gadi, Zack, Donald J.

“…Genetic variants in regions that include the mitochondrial genes thioredoxin reductase 2 (TXNRD2) and malic enzyme 3 (ME3) are associated with primary…”
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Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process by Springelkamp, Henriët., Höhn, René, Mishra, Aniket, Hysi, Pirro G., Khor, Chiea-Chuen, Loomis, Stephanie J., Bailey, Jessica N. Cooke, Gibson, Jane, Thorleifsson, Gudmar, Janssen, Sarah F., Luo, Xiaoyan, Ramdas, Wishal D., Vithana, Eranga, Nongpiur, Monisha E., Montgomery, Grant W., Xu, Liang, Mountain, Jenny E., Gharahkhani, Puya, Lu, Yi, Amin, Najaf, Karssen, Lennart C., Sim, Kar-Seng, van Leeuwen, Elisabeth M., Iglesias, Adriana I., Verhoeven, Virginie J. M., Hauser, Michael A., Loon, Seng-Chee, Despriet, Dominiek D. G., Nag, Abhishek, Venturini, Cristina, Sanfilippo, Paul G., Schillert, Arne, Kang, Jae H., Landers, John, Jonasson, Fridbert, Cree, Angela J., van Koolwijk, Leonieke M. E., Rivadeneira, Fernando, Souzeau, Emmanuelle, Jonsson, Vesteinn, Menon, Geeta, Weinreb, Robert N., de Jong, Paulus T. V. M., Oostra, Ben A., Uitterlinden, André G., Hofman, Albert, Ennis, Sarah, Thorsteinsdottir, Unnur, Burdon, Kathryn P., Spector, Timothy D., Mirshahi, Alireza, Saw, Seang-Mei, Vingerling, Johannes R., Teo, Yik-Ying, Haines, Jonathan L., Wolfs, Roger C. W., Lemij, Hans G., Tai, E-Shyong, Jansonius, Nomdo M., Jonas, Jost B., Cheng, Ching-Yu, Aung, Tin, Viswanathan, Ananth C., Klaver, Caroline C. W., Craig, Jamie E., Macgregor, Stuart, Mackey, David A., Lotery, Andrew J., Stefansson, Kari, Bergen, Arthur A. B., Young, Terri L., Wiggs, Janey L., Pfeiffer, Norbert, Wong, Tien-Yin, Pasquale, Louis R., Hewitt, Alex W., van Duijn, Cornelia M., Hammond, Christopher J.

“…Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International…”
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Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma by Liu, Wendy W., Kinzy, Tyler G., Cooke Bailey, Jessica N., Xu, Zihe, Hysi, Pirro, Wiggs, Janey L.

“…Although glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we investigated…”
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility by Chintalapudi, Sumana R., Maria, Doaa, Di Wang, Xiang, Bailey, Jessica N. Cooke, Hysi, Pirro G., Wiggs, Janey L., Williams, Robert W., Jablonski, Monica M.

“…Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor…”
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Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma by Carnes, Megan Ulmer, Liu, Yangfan P, Allingham, R Rand, Whigham, Benjamin T, Havens, Shane, Garrett, Melanie E, Qiao, Chunyan, Katsanis, Nicholas, Wiggs, Janey L, Pasquale, Louis R, Ashley-Koch, Allison, Oh, Edwin C, Hauser, Michael A

“…Glaucoma is a leading cause of blindness worldwide. Primary open-angle glaucoma (POAG) is the most common subtype and is a complex trait with multigenic…”
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Myocilin Mutations in Patients With Normal-Tension Glaucoma by Alward, Wallace L M, van der Heide, Carly, Khanna, Cheryl L, Roos, Ben R, Sivaprasad, Sobha, Kam, Jason, Ritch, Robert, Lotery, Andrew, Igo, Jr, Robert P, Cooke Bailey, Jessica N, Stone, Edwin M, Scheetz, Todd E, Kwon, Young H, Pasquale, Louis R, Wiggs, Janey L, Fingert, John H

“…Mutations in the myocilin (MYOC) gene are the most common molecularly defined cause of primary open-angle glaucoma that typically occurs in patients with high…”
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A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium by Liu, Yutao, Bailey, Jessica Cooke, Helwa, Inas, Dismuke, W Michael, Cai, Jingwen, Drewry, Michelle, Brilliant, Murray H, Budenz, Donald L, Christen, William G, Chasman, Daniel I, Fingert, John H, Gaasterland, Douglas, Gaasterland, Terry, Gordon, Mae O, Igo, Jr, Robert P, Kang, Jae H, Kass, Michael A, Kraft, Peter, Lee, Richard K, Lichter, Paul, Moroi, Sayoko E, Realini, Anthony, Richards, Julia E, Ritch, Robert, Schuman, Joel S, Scott, William K, Singh, Kuldev, Sit, Arthur J, Song, Yeunjoo E, Vollrath, Douglas, Weinreb, Robert, Medeiros, Felipe, Wollstein, Gadi, Zack, Donald J, Zhang, Kang, Pericak-Vance, Margaret A, Gonzalez, Pedro, Stamer, W Daniel, Kuchtey, John, Kuchtey, Rachel W, Allingham, R Rand, Hauser, Michael A, Pasquale, Louis R, Haines, Jonathan L, Wiggs, Janey L

“…Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated…”
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Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma by King, Rebecca, Struebing, Felix L, Li, Ying, Wang, Jiaxing, Koch, Allison Ashley, Cooke Bailey, Jessica N, Gharahkhani, Puya, MacGregor, Stuart, Allingham, R Rand, Hauser, Michael A, Wiggs, Janey L, Geisert, Eldon E

“…Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The…”
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Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology by Springelkamp, Henriët, Mishra, Aniket, Hysi, Pirro G., Gharahkhani, Puya, Höhn, René, Khor, Chiea-Chuen, Cooke Bailey, Jessica N., Luo, Xiaoyan, Ramdas, Wishal D., Vithana, Eranga, Koh, Victor, Yazar, Seyhan, Xu, Liang, Forward, Hannah, Kearns, Lisa S., Amin, Najaf, Iglesias, Adriana I., Sim, Kar-Seng, van Leeuwen, Elisabeth M., Demirkan, Ayse, van der Lee, Sven, Loon, Seng-Chee, Rivadeneira, Fernando, Nag, Abhishek, Sanfilippo, Paul G., Schillert, Arne, de Jong, Paulus T. V. M., Oostra, Ben A., Uitterlinden, André G., Hofman, Albert, Zhou, Tiger, Burdon, Kathryn P., Spector, Timothy D., Lackner, Karl J., Saw, Seang-Mei, Vingerling, Johannes R., Teo, Yik-Ying, Pasquale, Louis R., Wolfs, Roger C. W., Lemij, Hans G., Tai, E-Shyong, Jonas, Jost B., Cheng, Ching-Yu, Aung, Tin, Jansonius, Nomdo M., Klaver, Caroline C. W., Craig, Jamie E., Young, Terri L., Haines, Jonathan L., MacGregor, Stuart, Mackey, David A., Pfeiffer, Norbert, Wong, Tien-Yin, Wiggs, Janey L., Hewitt, Alex W., van Duijn, Cornelia M., Hammond, Christopher J.

“…ABSTRACT Primary open‐angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or…”
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Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma by Gharahkhani, Puya, Burdon, Kathryn P., Cooke Bailey, Jessica N., Hewitt, Alex W., Law, Matthew H., Pasquale, Louis R., Kang, Jae H., Haines, Jonathan L., Souzeau, Emmanuelle, Zhou, Tiger, Siggs, Owen M., Landers, John, Awadalla, Mona, Sharma, Shiwani, Mills, Richard A., Ridge, Bronwyn, Lynn, David, Casson, Robert, Graham, Stuart L., Goldberg, Ivan, White, Andrew, Healey, Paul R., Grigg, John, Lawlor, Mitchell, Mitchell, Paul, Ruddle, Jonathan, Coote, Michael, Walland, Mark, Best, Stephen, Vincent, Andrea, Gale, Jesse, RadfordSmith, Graham, Whiteman, David C., Montgomery, Grant W., Martin, Nicholas G., Mackey, David A, Wiggs, Janey L., MacGregor, Stuart, Craig, Jamie E.

“…Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG…”
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Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus by Fan, Bao Jian, Chen, Xueli, Sondhi, Nisha, Sharmila, P Ferdinamarie, Soumittra, Nagasamy, Sripriya, Sarangapani, Sacikala, Srinivasan, Asokan, Rashima, Friedman, David S, Pasquale, Louis R, Gao, X Raymond, Vijaya, Lingam, Cooke Bailey, Jessica, Vitart, Veronique, MacGregor, Stuart, Hammond, Christopher J, Khor, Chiea Chuen, Haines, Jonathan L, George, Ronnie, Wiggs, Janey L

“…To identify genetic risk factors contributing to central corneal thickness (CCT) in individuals from South India, a population with a high prevalence of ocular…”
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Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia by Ulmer, Megan, Li, Jun, Yaspan, Brian L, Ozel, Ayse Bilge, Richards, Julia E, Moroi, Sayoko E, Hawthorne, Felicia, Budenz, Donald L, Friedman, David S, Gaasterland, Douglas, Haines, Jonathan, Kang, Jae H, Lee, Richard, Lichter, Paul, Liu, Yutao, Pasquale, Louis R, Pericak-Vance, Margaret, Realini, Anthony, Schuman, Joel S, Singh, Kuldev, Vollrath, Douglas, Weinreb, Robert, Wollstein, Gadi, Zack, Donald J, Zhang, Kang, Young, Terri, Allingham, R Rand, Wiggs, Janey L, Ashley-Koch, Allison, Hauser, Michael A

“…To investigate the effects of central corneal thickness (CCT)-associated variants on primary open-angle glaucoma (POAG) risk using single nucleotide…”
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The NEIGHBOR Consortium Primary Open-Angle Glaucoma Genome-wide Association Study: Rationale, Study Design, and Clinical Variables by Wiggs, Janey L., Hauser, Michael A., Abdrabou, Wael, Allingham, Robert Rand, Budenz, Donald L., DelBono, Elizabeth, Friedman, David S., Kang, Jae H., Gaasterland, Douglas, Gaasterland, Terry, Lee, Richard K., Lichter, Paul R., Loomis, Stephanie, Liu, Yutao, McCarty, Cathy, Medeiros, Felipe A., Moroi, Sayoko E., Olson, Lana M., Realini, Anthony, Richards, Julia E., Rozsa, Frank W., Schuman, Joel S., Singh, Kuldev, Stein, Joshua D., Vollrath, Douglas, Weinreb, Robert N., Wollstein, Gadi, Yaspan, Brian L., Yoneyama, Sachiko, Zack, Don, Zhang, Kang, Pericak-Vance, Margaret, Pasquale, Louis R., Haines, Jonathan L.

“…Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward…”
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DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma by Liu, Yutao, Garrett, Melanie E, Yaspan, Brian L, Bailey, Jessica Cooke, Loomis, Stephanie J, Brilliant, Murray, Budenz, Donald L, Christen, William G, Fingert, John H, Gaasterland, Douglas, Gaasterland, Terry, Kang, Jae H, Lee, Richard K, Lichter, Paul, Moroi, Sayoko E, Realini, Anthony, Richards, Julia E, Schuman, Joel S, Scott, William K, Singh, Kuldev, Sit, Arthur J, Vollrath, Douglas, Weinreb, Robert, Wollstein, Gadi, Zack, Donald J, Zhang, Kang, Pericak-Vance, Margaret A, Haines, Jonathan L, Pasquale, Louis R, Wiggs, Janey L, Allingham, R Rand, Ashley-Koch, Allison E, Hauser, Michael A

“…We examined the role of DNA copy number variants (CNVs) of known glaucoma genes in relation to primary open angle glaucoma (POAG). Our study included DNA…”
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A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium by Liu, Yutao, Bailey, Jessica Cooke, Helwa, Inas, Dismuke, W. Michael, Cai, Jingwen, Drewry, Michelle, Brilliant, Murray H., Budenz, Donald L., Christen, William G., Chasman, Daniel I., Fingert, John H., Gaasterland, Douglas, Gaasterland, Terry, Gordon, Mae O., Igo, Robert P., Kang, Jae H., Kass, Michael A., Kraft, Peter, Lee, Richard K., Lichter, Paul, Moroi, Sayoko E., Realini, Anthony, Richards, Julia E., Ritch, Robert, Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Song, Yeunjoo E., Vollrath, Douglas, Weinreb, Robert, Medeiros, Felipe, Wollstein, Gadi, Zack, Donald J., Zhang, Kang, Pericak-Vance, Margaret A., Gonzalez, Pedro, Stamer, W. Daniel, Kuchtey, John, Kuchtey, Rachel W., Allingham, R. Rand, Hauser, Michael A., Pasquale, Louis R., Haines, Jonathan L., Wiggs, Janey L.

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Travoprost in the management of open-angle glaucoma and ocular hypertension by Denis, Philippe, Covert, David, Realini, Anthony

“…Travoprost is a member of the prostaglandin analogue class of intraocular pressure (IOP)-lowering drugs used to treat ocular hypertension and glaucoma. Like…”
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56,000 Ways to Treat Glaucoma by Ganley, James

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