Search Results - "Reale, Laura A."

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    Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex by Dyer, Marcus S., Reale, Laura A., Lewis, Katherine E., Walker, Adam K., Dickson, Tracey C., Woodhouse, Adele, Blizzard, Catherine A.

    Published in Journal of neurochemistry (01-05-2021)
    “…Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically characterised by mislocalisation of the RNA‐binding protein…”
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    Journal Article
  2. 2

    Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system by Reale, Laura A., Dyer, Marcus S., Perry, Sharn E., Young, Kaylene M., Dickson, Tracey C., Woodhouse, Adele, Blizzard, Catherine A.

    Published in Progress in neurobiology (01-07-2023)
    “…Alterations in upper motor neuron excitability are one of the earliest phenomena clinically detected in ALS, and in 97 % of cases, the RNA/DNA binding protein,…”
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    Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43 A315T Mouse Model of Amyotrophic Lateral Sclerosis by Handley, Emily E, Reale, Laura A, Chuckowree, Jyoti A, Dyer, Marcus S, Barnett, Grace L, Clark, Courtney M, Bennett, William, Dickson, Tracey C, Blizzard, Catherine A

    Published in Molecular neurobiology (01-05-2022)
    “…Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower…”
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    Journal Article