Search Results - "Real, Alexander"
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Structural basis for the action of the drug trametinib at KSR-bound MEK
Published in Nature (London) (17-12-2020)“…The MAPK/ERK kinase MEK is a shared effector of the frequent cancer drivers KRAS and BRAF that has long been pursued as a drug target in oncology 1 , and more…”
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Type II Binders Targeting the “GLR-Out” Conformation of the Pseudokinase STRADα
Published in Biochemistry (Easton) (02-02-2021)“…Pseudokinases play important roles in signal transduction and cellular processes similar to those of catalytically competent kinases. However, pseudokinase…”
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Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance
Published in Cell chemical biology (16-07-2020)“…In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor…”
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The TCI Clinical Encounter Program for PhD Students in Cancer Biology: a Feasibility Pilot
Published in Journal of cancer education (01-02-2023)“…Clinical rotations are often not included in graduate-level cancer biology curricula; however, basic insight into clinical oncology is often crucial for…”
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Desirability and information processing: An experimental study
Published in Economics letters (01-03-2017)“…I study, in an experimental setting, how individuals process news regarding the likelihood of an event that is desirable, but not ego-relevant. I hypothesize…”
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Moral Perceptions of Advised Actions
Published in Management science (01-08-2019)“…Can an organization avoid blame for an unpopular action when an adviser advises it to do it? We present experimental evidence suggesting this is the…”
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Nicotinamide N-oxidation by CYP2E1 in human liver microsomes
Published in Drug metabolism and disposition (01-03-2013)“…Excess nicotinamide, a form of vitamin B(3), is metabolized through two enzymatic systems and eventually excreted from the body. The first system starts with…”
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A whole-animal platform to advance a clinical kinase inhibitor into new disease space
Published in Nature chemical biology (01-03-2018)“…Combining Drosophila genetics with chemistry and computation led to the development of novel kinase inhibitors based on the RAF-targeting drug sorafenib that…”
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Small Molecule Interactions Directed to the Scaffold Kinase Suppressor of Ras Modulate MAPK Signaling in Cancer
Published 01-01-2022“…Small Molecule Interactions Directed to the Scaffold Kinase Suppressor of Ras Modulate MAPK Signaling in Cancerby Alexander Michael RealAdvisor: Arvin C…”
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Dissertation
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Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain in Non-Overweight Diabetics
Published in The spine journal (31-05-2018)Get full text
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Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics
Published in The spine journal (01-02-2019)“…Low back pain (LBP) is a common complaint in clinical practice of multifactorial origin. Although obesity has been thought to contribute to LBP primarily by…”
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Essays in behavioral economics
Published 01-01-2015“…The simple and traditional approach in economics is to model individuals as making decisions that maximize their own (expected) material payoff. A large part…”
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Dissertation -
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Essays in behavioral economics
“…The simple and traditional approach in economics is to model individuals as making decisions that maximize their own (expected) material payoff. A large part…”
Get full text
Dissertation -
14