Search Results - "Reagan, Jerry W."

Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression by Maguire, Jean Ann, Reagan, Jerry W

“…The sterol regulatory element binding protein (SREBP)/SREBP cleavage-activating protein (SCAP) complex regulates the transcription of numerous genes involved…”
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Posttranslational Regulation of Acid Sphingomyelinase in Niemann-Pick Type C1 Fibroblasts and Free Cholesterol-enriched Chinese Hamster Ovary Cells by Reagan, Jerry W., Hubbert, Melissa L., Shelness, Gregory S.

“…Niemann-Pick type C disease is characterized by the accumulation of cholesterol and other lipids within the lysosomal compartment, a process that is often…”
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Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates by Anderson, Richard A., Joyce, Charles, Davis, Matthew, Reagan, Jerry W., Clark, Michelle, Shelness, Gregory S., Rudel, Lawrence L.

“…The present study demonstrates that two different forms of the intracellular cholesterol esterification enzyme acyl-CoA:cholesterol acyltransferase (ACAT) are…”
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Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux by Nordskog, B K, Reagan, Jr, J W, St Clair, R W

“…The extent to which cholesterol synthesis is modulated in macrophage foam cells by changes in cholesterol influx and efflux was determined using…”
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The Pathogenesis of Foam Cell Formation: Modified LDL Stimulates Uptake of Co-Incubated LDL Via Macropinocytosis by Jones, Nancy L, Reagan, Jerry W, Willingham, Mark C

“…ABSTRACTPreviously, modified LDLs were shown to stimulate macropinocytosis in pigeon macrophages. Simultaneous intracellular trafficking of LDL and AcLDL,…”
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Translocation of both lysosomal LDL-derived cholesterol and plasma membrane cholesterol to the endoplasmic reticulum for esterification may require common cellular factors involved in cholesterol egress from the acidic compartments (lysosomes/endosomes) by Spillane, Diane M., Reagan, Jerry W., Kennedy, Norman J., Schneider, Donald L., Chang, Ta-Yuan

“…Using a stable cell line 25-RA derived from wild-type Chinese hamster ovary (CHO) cells as the parental cell, this laboratory previously reported the isolation…”
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In vivo clearance of low density lipoprotein in pigeons occurs by a receptor-like mechanism that is not down-regulated by cholesterol feeding by J W Reagan, Jr, L R Miller, R W St Clair

“…The contribution of receptor-dependent and receptor-independent mechanisms for low density lipoprotein (LDL) clearance in vivo was determined in White Carneau…”
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