Search Results - "Reagan, Alaina M."

Caveolins and caveolae in ocular physiology and pathophysiology by Gu, Xiaowu, Reagan, Alaina M., McClellan, Mark E., Elliott, Michael H.

“…Caveolae are specialized, invaginated plasma membrane domains that are defined morphologically and by the expression of signature proteins called, caveolins…”
Get full text

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity by Yang, Hongtian, Graham, Leah C, Reagan, Alaina M, Grabowska, Weronika A, Schott, William H, Howell, Gareth R

“…Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and…”
Get full text

Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma by Elliott, Michael H., Ashpole, Nicole E., Gu, Xiaowu, Herrnberger, Leonie, McClellan, Mark E., Griffith, Gina L., Reagan, Alaina M., Boyce, Timothy M., Tanito, Masaki, Tamm, Ernst R., Stamer, W. Daniel

“…Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are associated with glaucoma, the second leading cause of blindness worldwide, and…”
Get full text

Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation by Li, Xiaoman, Gu, Xiaowu, Boyce, Timothy M, Zheng, Min, Reagan, Alaina M, Qi, Hui, Mandal, Nawajes, Cohen, Alex W, Callegan, Michelle C, Carr, Daniel J J, Elliott, Michael H

“…Caveolin-1 (Cav-1), the signature protein of caveolae, modulates inflammatory responses, and innate immunity. However, Cav-1's role in retinal inflammation has…”
Get full text

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation by Martínez Duncker Rebolledo, Edgar, Chan, Donovan, Christensen, Karen E, Reagan, Alaina M, Howell, Gareth R, Rozen, Rima, Trasler, Jacquetta

“…Abstract 5,10-Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a key role in providing methyl groups for DNA methylation, including during…”
Get full text

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice by Reagan, Alaina M, Christensen, Karen E, Graham, Leah C, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Figueiredo, Lucas L, Persohn, Scott C, Bottiglieri, Teodoro, Nho, Kwangsik, Sasner, Michael, Territo, Paul R, Rozen, Rima, Howell, Gareth R

“…Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however,…”
Get full text

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex‐Specific Manner by Leclerc, Daniel, Christensen, Karen E., Reagan, Alaina M., Keser, Vafa, Luan, Yan, Malysheva, Olga V., Wasek, Brandi, Bottiglieri, Teodoro, Caudill, Marie A., Howell, Gareth R., Rozen, Rima

“…Scope Disturbances in one‐carbon metabolism contribute to nonalcoholic fatty liver disease (NAFLD) which encompasses steatosis, steatohepatitis, fibrosis, and…”
Get full text

Folate Deficiency and/or the Genetic Variant Mthfr 677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner by Leclerc, Daniel, Christensen, Karen E, Reagan, Alaina M, Keser, Vafa, Luan, Yan, Malysheva, Olga V, Wasek, Brandi, Bottiglieri, Teodoro, Caudill, Marie A, Howell, Gareth R, Rozen, Rima

“…Disturbances in one-carbon metabolism contribute to nonalcoholic fatty liver disease (NAFLD) which encompasses steatosis, steatohepatitis, fibrosis, and…”
Get full text

Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency by Reagan, Alaina M., Gu, Xiaowu, Paudel, Sijalu, Ashpole, Nicole M., Zalles, Michelle, Sonntag, William E., Ungvari, Zoltan, Csiszar, Anna, Otalora, Laura, Freeman, Willard M., Stout, Michael B., Elliott, Michael H.

“…Cerebral microcirculation is critical for the preservation of brain health, and vascular impairment is associated with age-related neurodegenerative diseases…”
Get full text

Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection by Royer, Derek J., Hendrix, Joshua F., Larabee, Chelsea M., Reagan, Alaina M., Sjoelund, Virginie H., Robertson, Danielle M., Carr, Daniel J. J.

“…The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity…”
Get full text

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma by Buchanan, Rebecca A, Foley, Kate E, Pepper, Keating W, Reagan, Alaina M, Keezer, Kelly J, Hewes, Amanda A, Diemler, Cory A, Preuss, Christoph, Soto, Ileana, John, Simon W M, Howell, Gareth R

“…Glaucoma is a complex disease with major risk factors including advancing age and increased intraocular pressure (IOP). Dissecting these earliest events will…”
Get full text

Vascular Inflammation Risk Factors in Retinal Disease by Soto, Ileana, Krebs, Mark P, Reagan, Alaina M, Howell, Gareth R

“…Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among…”
Get full text

Improving mouse models for the study of Alzheimer's disease by Reagan, Alaina M, Onos, Kristen D, Heuer, Sarah E, Sasner, Michael, Howell, Gareth R

“…Alzheimer's disease (AD) is a complex neurodegenerative disease whose risk is influenced by genetic and environmental factors. Although a number of…”
Get full text

Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice by Oblak, Adrian L., Kotredes, Kevin P., Pandey, Ravi S., Reagan, Alaina M., Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B., Soni, Disha M., Tsai, Andy P., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A., Peters, Johnathan S., Figueiredo, Lucas L., Sasner, Michael, Territo, Paul R., Sukoff Rizzo, Stacey J., Carter, Gregory W., Lamb, Bruce T., Howell, Gareth R.

“…Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related…”
Get full text

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma by Buchanan, Rebecca A., Foley, Kate E., Pepper, Keating W., Reagan, Alaina M., Keezer, Kelly J., Hewes, Amanda A., Diemler, Cory A., Preuss, Christoph, Soto, Ileana, John, Simon W. M., Howell, Gareth R.

Get full text

Model‐EyeD: Harnessing the potential of the eye as a biomarker for Alzheimer’s disease and related dementias by Howell, Gareth R, Marola, Olivia J, Maclean, Michael, Cossette, Travis L, Hewes, Amanda, Morgan, James, Singer, Cliff, Risacher, Shannon L., Onos, Kristen D, Reagan, Alaina M

“…Background Disease‐modifying treatments for Alzheimer’s disease and related dementias (ADRD) will be most effective early in the disease process. Clinical use…”
Get full text

A common risk variant in the MTHFR gene contributes to age‐related cerebrovascular dysfunction in VCID: Development of new models and analysis methods/novel assays and technologies by Reagan, Alaina M., Christensen, Karen, Haber, Annat, Rozen, Rima, Carter, Gregory W., Sasner, Michael, Howell, Gareth

“…Abstract Background Cerebrovascular damage occurs during aging, Alzheimer’s disease and Vascular Dementia, commonly referred to as Vascular Contributions to…”
Get full text

A common risk variant in the MTHFR gene contributes to age‐related cerebrovascular dysfunction in VCID by Reagan, Alaina M., Christensen, Karen, Haber, Annat, Rozen, Rima, Carter, Gregory W., Sasner, Michael, Howell, Gareth

“…Background Cerebrovascular damage occurs during aging, Alzheimer’s disease and Vascular Dementia, commonly referred to as Vascular Contributions to Cognitive…”
Get full text

The synergistic role of high‐fat diet and genetic predisposition in Alzheimer’s disease by Oblak, Adrian L, Kotredes, Kevin P, Reagan, Alaina M, Pandey, Ravi S, Sasner, Michael, Carter, Gregory W, Lamb, Bruce T., Howell, Gareth R

“…Background Age, genetic variants, and environmental factors such as consumption of a high fat diet contribute to Alzheimer’s disease (AD) risk. Diets high in…”
Get full text

A COMMON RISK VARIANT IN THE MTHFR GENE CONTRIBUTES TO CEREBROVASCULAR DYSFUNCTION IN MIXED DEMENTIA by Reagan, Alaina M., Kotredes, Kevin P., Williams, Harriet M., O'Rourke, Rita, O'Rourke, Sarah, Carter, Gregory W., Sasner, Michael, Howell, Gareth

Get full text