Search Results - "Read, R. J."

Structure of a serpin-protease complex shows inhibition by deformation by Huntington, James A, Read, Randy J, Carrell, Robin W

“…The serpins have evolved to be the predominant family of serine-protease inhibitors in man. Their unique mechanism of inhibition involves a profound change in…”
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Molecular pathology of X linked retinoschisis: mutations interfere with retinoschisin secretion and oligomerisation by Wang, T, Zhou, A, Waters, C T, O’Connor, E, Read, R J, Trump, D

“…Background/aim: X linked retinoschisis (XLRS) is caused by mutations in RS1 which encodes the discoidin domain protein retinoschisin, secreted by…”
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Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands by Bundle, David R, Kitov, Pavel I, Sadowska, Joanna M, Mulvey, George, Armstrong, Glen D, Ling, Hong, Pannu, Navraj S, Read, Randy J

“…The diseases caused by Shiga and cholera toxins account for the loss of millions of lives each year. Both belong to the clinically significant subset of…”
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Intra-articular morphine and bupivicaine for post-operative analgesia in anterior cruciate ligament reconstruction: a prospective randomised controlled trial by Senthilkumaran, S., Tate, R., Read, J. R. M., Sutherland, A. G.

“…Anterior cruciate ligament reconstruction (ACLR) has the potential for significant post-operative pain. Conventional systemic opiate treatment may cause nausea…”
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination by Brünger, Axel T., Adams, Paul D., Clore, G. Marius, DeLano, Warren L., Gros, Piet, Grosse-Kunstleve, Ralf W., Jiang, Jian-Sheng, Kuszewski, John, Nilges, Michael, Pannu, Navraj S., Read, Randy J., Rice, Luke M., Simonson, Thomas, Warren, Gregory L.

“…A new software suite, called Crystallography & NMR System (CNS), has been developed for macromolecular structure determination by X‐ray crystallography or…”
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Pushing the boundaries of molecular replacement with maximum likelihood by Read, Randy J.

“…The molecular‐replacement method works well with good models and simple unit cells, but often fails with more difficult problems. Experience with likelihood in…”
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The identification of three biologically relevant globotriaosyl ceramide receptor binding sites on the Verotoxin 1 B subunit by Bast, D. J., Banerjee, L., Clark, C., Read, R. J., Brunton, J. L.

“…The Verotoxin 1 (VT1) B subunit binds to the glycosphingolipid receptor globotriaosylceramide (Gb3). Receptor‐binding specificity is associated with the…”
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A multiple-start Monte Carlo docking method by Hart, T N, Read, R J

“…We present a method to search for possible binding modes of molecular fragments at a specific site of a potential drug target of known structure. Our method is…”
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Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from trypanosoma brucei determined from Laue data by Vellieux, F.M.D. (University of Groningen, Groningen, Netherlands), Hajdu, J, Verlinde, C.L.M.J, Groenduk, H, Read, R.J, Greenhough, T.J, Campbell, J.W, Kalk, K.H, Littlechild, J.A, Watson, H.C

“…The three-dimensional structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase [D-glyceraldehyde-3-phosphate: NAD+ oxidoreductase (phosphorylating), EC…”
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Accumulating Evidence Suggests That Several AB-Toxins Subvert the Endoplasmic Reticulum-Associated Protein Degradation Pathway To Enter Target Cells by Hazes, Bart, Read, Randy J

“…Several AB-toxins appear to have independently evolved mechanisms by which they undergo retrograde transport from the cell membrane to the endoplasmic…”
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Epidural anaesthesia as a method of pre‐emptive analgesia for abdominal hysterectomy by Richards, J. T., Read, J. R. M., Chambers, W. A.

“…The effect of pre‐ versus postincisional epidural blockade without the use of systemic opioids was investigated in a randomised, double‐blind study of two…”
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Atomic solvation parameters in the analysis of protein‐protein docking results by Cummings, Maxwell D., Read, Randy J., Hart, Trevor N.

“…Several sets of amino acid surface areas and transfer free energies were used to derive a total of nine sets of atomic solvation parameters (ASPs). We tested…”
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Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease by Gooptu, B, Hazes, B, Chang, W S, Dafforn, T R, Carrell, R W, Read, R J, Lomas, D A

“…The serpins are a family of proteinase inhibitors that play a central role in the control of proteolytic cascades. Their inhibitory mechanism depends on the…”
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X-ray structure of lipoamide dehydrogenase from Azotobacter vinelandii determined by a combination of molecular and isomorphous replacement techniques by Schierbeek, A J, Swarte, M B, Dijkstra, B W, Vriend, G, Read, R J, Hol, W G, Drenth, J, Betzel, C

“…The crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii has been determined by a combination of molecular replacement and isomorphous…”
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Simple algorithm for a maximum-likelihood SAD function by McCoy, Airlie J., Storoni, Laurent C., Read, Randy J.

“…Recently, the multivariate complex normal distribution has been used to develop a maximum‐likelihood probability function for single‐wavelength anomalous…”
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Cross-Validated Maximum Likelihood Enhances Crystallographic Simulated Annealing Refinement by Adams, Paul D., Pannu, Navraj S., Read, Randy J., Brünger, Axel T.

“…Recently, the target function for crystallographic refinement has been improved through a maximum likelihood analysis, which makes proper allowance for the…”
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Dynamic gradient-echo and fat-suppressed spin-echo contrast-enhanced MRI of the breast by Kerslake, R.W., Carleton, P.J., Fox, J.N., Imrie, M.J., Cook, A.M., Read, J.R., Bowsley, S.J., Buckley, D.L., Horsman, A.

“…Purpose:To evaluate heavily T2-weighted, dynamic contrast-enhanced and fat-suppressed magnetic resonance imaging (MRI) of the breast in comparison with…”
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Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution by Read, R J, James, M N

“…Streptomyces griseus trypsin (SGT) is a bacterial serine proteinase that is more homologous to mammalian than to other bacterial enzymes. The structure of SGT…”
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Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding by Hazes, B, Sastry, P A, Hayakawa, K, Read, R J, Irvin, R T

“…Fibers of pilin monomers (pili) form the dominant adhesin of Pseudomonas aeruginosa, and they play an important role in infections by this opportunistic…”
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Not your average density by Kleywegt, Gerard J, Read, Randy J

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