Search Results - "Read, Martin"

Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors by Nieto, Hannah R, Thornton, Caitlin E M, Brookes, Katie, Nobre de Menezes, Albert, Fletcher, Alice, Alshahrani, Mohammed, Kocbiyik, Merve, Sharma, Neil, Boelaert, Kristien, Cazier, Jean-Baptiste, Mehanna, Hisham, Smith, Vicki E, Read, Martin L, McCabe, Christopher J

“…Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical tools, often…”
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Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo by Read, Martin L, Brookes, Katie, Zha, Ling, Manivannan, Selvambigai, Kim, Jana, Kocbiyik, Merve, Fletcher, Alice, Gorvin, Caroline M, Firth, George, Fruhwirth, Gilbert O, Nicola, Juan P, Jhiang, Sissy, Ringel, Matthew D, Campbell, Moray J, Sunassee, Kavitha, Blower, Philip J, Boelaert, Kristien, Nieto, Hannah R, Smith, Vicki E, McCabe, Christopher J

“…Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM)…”
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Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake by Fletcher, Alice, Read, Martin L, Thornton, Caitlin E M, Larner, Dean P, Poole, Vikki L, Brookes, Katie, Nieto, Hannah R, Alshahrani, Mohammed, Thompson, Rebecca J, Lavery, Gareth G, Landa, Iñigo, Fagin, James A, Campbell, Moray J, Boelaert, Kristien, Turnell, Andrew S, Smith, Vicki E, McCabe, Christopher J

“…The sodium iodide symporter (NIS) is required for iodide uptake, which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in…”
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Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER by Gilligan, Lorna C, Rahman, Habibur P, Hewitt, Anne-Marie, Sitch, Alice J, Gondal, Ali, Arvaniti, Anastasia, Taylor, Angela E, Read, Martin L, Morton, Dion G, Foster, Paul A

“…Abstract Context Estrogens affect the incidence and progression of colorectal cancer (CRC), although the precise molecular mechanisms remain ill-defined…”
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Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter by Read, Martin L, Brookes, Katie, Thornton, Caitlin E M, Fletcher, Alice, Nieto, Hannah R, Alshahrani, Mohammed, Khan, Rashida, Borges de Souza, Patricia, Zha, Ling, Webster, Jamie R M, Alderwick, Luke J, Campbell, Moray J, Boelaert, Kristien, Smith, Vicki E, McCabe, Christopher J

“…The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS…”
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The potential interaction between medical treatment and radioiodine treatment success: A systematic review by Zannat, Riazul, Lee, Jonathan, Muzaffar, Jameel, Read, Martin L, Brookes, Katie, Sharma, Neil, Boelaert, Kristien, McCabe, Christopher J, Nieto, Hannah R

“…Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic…”
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PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer by Read, Martin L, Modasia, Bhavika, Fletcher, Alice, Thompson, Rebecca J, Brookes, Katie, Rae, Peter C, Nieto, Hannah R, Poole, Vikki L, Roberts, Sally, Campbell, Moray J, Boelaert, Kristien, Turnell, Andrew S, Smith, Vicki E, Mehanna, Hisham, McCabe, Christopher J

“…Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and poses a significant health burden due to its rising incidence…”
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Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication by Nazeer, Reshma, Qashqari, Fadi S I, Albalawi, Abeer S, Piberger, Ann Liza, Tilotta, Maria Teresa, Read, Martin L, Hu, Siyuan, Davis, Simon, McCabe, Christopher J, Petermann, Eva, Turnell, Andrew S

“…Here, we show that the cellular DNA replication protein and ATR substrate SMARCAL1 is recruited to viral replication centers early during adenovirus infection…”
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The design of G-quadruplex ligands as telomerase inhibitors by Cuesta, Javier, Read, Martin A, Neidle, Stephen

“…Guanine-rich repetitive DNA sequences are of particular importance at the ends of chromosomes, where they are associated with a number of proteins to form…”
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Dimerization of the Sodium/Iodide Symporter by Thompson, Rebecca J, Fletcher, Alice, Brookes, Katie, Nieto, Hannah, Alshahrani, Mohammed M, Mueller, Jonathan W, Fine, Nicholas H F, Hodson, David J, Boelaert, Kristien, Read, Martin L, Smith, Vicki E, McCabe, Christopher J

“…The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid…”
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A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids by Read, Martin L., Singh, Surjeet, Ahmed, Zubair, Stevenson, Mark, Briggs, Simon S., Oupicky, David, Barrett, Lee B., Spice, Rachel, Kendall, Mark, Berry, Martin, Preece, Jon A., Logan, Ann, Seymour, Leonard W.

“…Synthetic vectors based on reducible polycations consisting of histidine and polylysine residues (HIS RPCs) were evaluated for their ability to deliver nucleic…”
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Germline ESR2 mutation predisposes to medullary thyroid carcinoma and causes up-regulation of RET expression by Smith, Joel, Read, Martin L, Hoffman, Jon, Brown, Rachel, Bradshaw, Beth, Campbell, Christopher, Cole, Trevor, Navas, Johanna Dieguez, Eatock, Fiona, Gundara, Justin S, Lian, Eric, Mcmullan, Dom, Morgan, Neil V, Mulligan, Lois, Morrison, Patrick J, Robledo, Mercedes, Simpson, Michael A, Smith, Vicki E, Stewart, Sue, Trembath, Richard C, Sidhu, Stan, Togneri, Fiona S, Wake, Naomi C, Wallis, Yvonne, Watkinson, John C, Maher, Eamonn R, McCabe, Christopher J, Woodward, Emma R

“…Familial medullary thyroid cancer (MTC) and its precursor, C cell hyperplasia (CCH), is associated with germline RET mutations causing multiple endocrine…”
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Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region by Gambini, Luca, Rizzi, Luca, Pedretti, Alessandro, Taglialatela-Scafati, Orazio, Carucci, Mario, Pancotti, Andrea, Galli, Corinna, Read, Martin, Giurisato, Emanuele, Romeo, Sergio, Russo, Ilaria

“…Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in…”
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The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy by Seed, Robert I., Taurozzi, Alberto J., Wilcock, Daniel J., Nappo, Giovanna, Erb, Holger H. H., Read, Martin L., Gurney, Mark, Archer, Leanne K., Ito, Saburo, Rumsby, Martin G., Petrie, John L., Clayton, Aled, Maitland, Norman J., Collins, Anne T.

“…Loss of latexin (LXN) expression negatively correlates with the prognosis of several human cancers. Despite association with numerous processes including…”
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Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin by Watkins, Rachel J, Imruetaicharoenchoke, Waraporn, Read, Martin L, Sharma, Neil, Poole, Vikki L, Gentilin, Erica, Bansal, Sukhchain, Bosseboeuf, Emy, Fletcher, Rachel, Nieto, Hannah R, Mallick, Ujjal, Hackshaw, Allan, Mehanna, Hisham, Boelaert, Kristien, Smith, Vicki E, McCabe, Christopher J

“…Context: Metastatic disease is responsible for the majority of endocrine cancer deaths. New therapeutic targets are urgently needed to improve patient survival…”
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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity by Gowan, Sharon M, Harrison, John R, Patterson, Lisa, Valenti, Melanie, Read, Martin A, Neidle, Stephen, Kelland, Lloyd R

“…The telomerase complex is responsible for telomere maintenance and represents a promising cancer therapeutic target. We describe herein the antitelomerase and…”
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A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer by Smith, Vicki E, Read, Martin L, Turnell, Andrew S, Watkins, Rachel J, Watkinson, John C, Lewy, Greg D, Fong, Jim C W, James, Sally R, Eggo, Margaret C, Boelaert, Kristien, Franklyn, Jayne A, McCabe, Christopher J

“…Differentiated thyroid cancers and their metastases frequently exhibit reduced iodide uptake, impacting on the efficacy of radioiodine ablation therapy. PTTG…”
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Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment by Read, Martin L, Lewy, Greg D, Fong, Jim C W, Sharma, Neil, Seed, Robert I, Smith, Vicki E, Gentilin, Erica, Warfield, Adrian, Eggo, Margaret C, Knauf, Jeffrey A, Leadbeater, Wendy E, Watkinson, John C, Franklyn, Jayne A, Boelaert, Kristien, McCabe, Christopher J

“…Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized proto-oncogene that has been implicated in the etiology of…”
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Delivery of siRNA mediated by histidine-containing reducible polycations by Stevenson, Mark, Ramos-Perez, Victor, Singh, Surjeet, Soliman, Mahmoud, Preece, Jon A., Briggs, Simon S., Read, Martin L., Seymour, Leonard W.

“…Histidine containing reducible polycations based on CH 6K 3H 6C monomers (His6 RPCs), are highly effective DNA transfection agents combining pH buffering…”
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The PTTG1-Binding Factor (PBF/PTTG1IP) Regulates p53 Activity in Thyroid Cells by Read, Martin L, Seed, Robert I, Fong, Jim C.W, Modasia, Bhavika, Ryan, Gavin A, Watkins, Rachel J, Gagliano, Teresa, Smith, Vicki E, Stratford, Anna L, Kwan, Perkin K, Sharma, Neil, Dixon, Olivia M, Watkinson, John C, Boelaert, Kristien, Franklyn, Jayne A, Turnell, Andrew S, McCabe, Christopher J

“…The PTTG1-binding factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a protooncogene. High PBF…”
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