Search Results - "Read, Andrew"
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Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?
Published in PLoS computational biology (01-01-2016)“…High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to…”
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2
The ecology of whales in a changing climate
Published in Science (American Association for the Advancement of Science) (13-10-2023)“…Some whale populations are exhibiting unexpected cycles of boom and bust The study of whale ecology did not begin until most populations had been depleted by…”
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3
On the apparent line-of-sight alignment of the peak X-ray intensity of the magnetosheath and the tangent to the magnetopause, as viewed by SMILE-SXI
Published in Earth and planetary physics (2024)“…The Soft X-ray Imager(SXI)on board the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)spacecraft will be able to view the Earth's magnetosheath in…”
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How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient
Published in PLoS biology (09-02-2017)“…When resistance to anticancer or antimicrobial drugs evolves in a patient, highly effective chemotherapy can fail, threatening patient health and lifespan…”
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5
Monitor for COVID-19 vaccine resistance evolution during clinical trials
Published in PLoS biology (01-11-2020)“…Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that COVID-19 vaccines…”
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Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens
Published in PLoS biology (01-07-2015)“…Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host…”
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The looming crisis: interactions between marine mammals and fisheries
Published in Journal of mammalogy (01-06-2008)“…Direct fisheries interactions pose a serious threat to the conservation of many populations and some species of marine mammals. The most acute problem is…”
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Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2018)“…Vaccines and antimicrobial drugs both impose strong selection for resistance. Yet only drug resistance is a major challenge for 21st century medicine. Why is…”
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Why does drug resistance readily evolve but vaccine resistance does not?
Published in Proceedings of the Royal Society. B, Biological sciences (29-03-2017)“…Why is drug resistance common and vaccine resistance rare? Drugs and vaccines both impose substantial pressure on pathogen populations to evolve resistance and…”
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Insecticide control of vector-borne diseases: when is insecticide resistance a problem?
Published in PLoS pathogens (01-08-2010)“…Many of the most dangerous human diseases are transmitted by insect vectors. After decades of repeated insecticide use, all of these vector species have…”
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11
Modifying Adaptive Therapy to Enhance Competitive Suppression
Published in Cancers (28-11-2020)“…Adaptive therapy is a promising new approach to cancer treatment. It is designed to leverage competition between drug-sensitive and drug-resistant cells in…”
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evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy
Published in Proceedings of the National Academy of Sciences - PNAS (28-06-2011)“…The evolution of drug-resistant pathogens is a major challenge for 21st century medicine. Drug use practices vigorously advocated as resistance management…”
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13
The effect of temperature on Anopheles mosquito population dynamics and the potential for malaria transmission
Published in PloS one (14-11-2013)“…The parasites that cause malaria depend on Anopheles mosquitoes for transmission; because of this, mosquito population dynamics are a key determinant of…”
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14
Superbugs: The Race to Stop an Epidemic
Published in Emerging Infectious Diseases (01-05-2020)“…Pennsylvania State University, University Park, Pennsylvania, USA Cite This Article DOI: 10.3201/eid2605.191717 Original Publication Date: April 09, 2020…”
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Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations
Published in PLoS biology (15-05-2020)“…Standard infectious disease practice calls for aggressive drug treatment that rapidly eliminates the pathogen population before resistance can emerge. When…”
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Decomposing health: tolerance and resistance to parasites in animals
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (12-01-2009)“…Plant biologists have long recognized that host defence against parasites and pathogens can be divided into two conceptually different components: the ability…”
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Empty promises: The European Union is failing to protect dolphins and porpoises from fisheries by‐catch
Published in Fish and fisheries (Oxford, England) (01-07-2021)“…By‐catch is the primary global conservation threat to populations of dolphins and porpoises. Despite protection for these protected species under its Habitats…”
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Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi)
Published in PloS one (24-10-2018)“…In mid-February 2015, a large number of deaths were observed in the sole extant population of an endangered species of freshwater snapping turtle, Myuchelys…”
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Pathogen evolution during vaccination campaigns
Published in PLoS biology (23-09-2022)“…Following the initiation of the unprecedented global vaccination campaign against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), attention has…”
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Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
Published in Science (American Association for the Advancement of Science) (02-11-2007)“…Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable…”
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