Search Results - "Razzo, Beatrice"

Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells by Ludwig, Nils, Yerneni, Saigopalakrishna S, Razzo, Beatrice M, Whiteside, Theresa L

“…For solid tumors, such as head and neck squamous cell carcinoma (HNSCC), an adequate blood supply is of critical importance for tumor development and…”
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Optimization of cell culture conditions for exosome isolation using mini-size exclusion chromatography (mini-SEC) by Ludwig, Nils, Razzo, Beatrice M., Yerneni, Saigopalakrishna S., Whiteside, Theresa. L.

“…Extracellular vesicles (EVs) are emerging as a major intercellular communication system engaged in a variety of physiological and pathophysiological processes…”
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The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation by Sweeny, Elizabeth A., Jackrel, Meredith E., Go, Michelle S., Sochor, Matthew A., Razzo, Beatrice M., DeSantis, Morgan E., Gupta, Kushol, Shorter, James

“…The structural basis by which Hsp104 dissolves disordered aggregates and prions is unknown. A single subunit within the Hsp104 hexamer can solubilize…”
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Tumor-derived exosomes promote carcinogenesis of murine oral squamous cell carcinoma by Razzo, Beatrice M, Ludwig, Nils, Hong, Chang-Sook, Sharma, Priyanka, Fabian, Kellsye P, Fecek, Ronald J, Storkus, Walter J, Whiteside, Theresa L

“…Circulating tumor-derived exosomes (TEX) interact with a variety of cells in cancer-bearing hosts, leading to cellular reprogramming which promotes disease…”
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Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients by Caro, Jessica, Braunstein, Marc, Williams, Louis, Bruno, Benedetto, Kaminetzky, David, Siegel, Ariel, Razzo, Beatrice, Alfandari, Serge, Morgan, Gareth J., Davies, Faith E., Boyle, Eileen M.

“…The role of infection and chronic inflammation in plasma cell disorders (PCD) has been well-described. Despite not being a diagnostic criterion, infection is a…”
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Improving prognostic assignment in older adults with multiple myeloma using acquired genetic features, clonal hemopoiesis and telomere length by Boyle, Eileen M., Williams, Louis, Blaney, Patrick, Ashby, Cody, Bauer, Michael, Walker, Brian A., Ghamlouch, Hussein, Choi, Jinyoung, Perrial, Emeline, Wang, Yubao, Caro, Jessica, Stoeckle, James H., Arbini, Arnaldo, Kaminetzky, David, Braunstein, Marc, Bruno, Benedetto, Razzo, Beatrice, Diamond, Benjamin, Maclachlan, Kylee, Maura, Francesco, Landgren, Ola, Litke, Rachel, Fegan, Christopher D., Keats, Johnathan, Auclair, Daniel, Davies, Faith E., Morgan, Gareth J.

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Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma by Ludwig, Sonja, Hong, Chang-Sook, Razzo, Beatrice M., Fabian, Kellsye P. L., Chelvanambi, Manoj, Lang, Stephan, Storkus, Walter J., Whiteside, Theresa L.

“…Advanced oral squamous cell carcinomas (OSCC) have limited therapeutic options. Although immune therapies are emerging as a potentially effective alternative…”
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TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype by Ludwig, Nils, Yerneni, Saigopalakrishna S., Azambuja, Juliana H., Pietrowska, Monika, Widłak, Piotr, Hinck, Cynthia S., Głuszko, Alicja, Szczepański, Mirosław J., Kärmer, Teresa, Kallinger, Isabella, Schulz, Daniela, Bauer, Richard J., Spanier, Gerrit, Spoerl, Steffen, Meier, Johannes K., Ettl, Tobias, Razzo, Beatrice M., Reichert, Torsten E., Hinck, Andrew P., Whiteside, Theresa L.

“…Transforming growth factor β (TGFβ) is a major component of tumor‐derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ+…”
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Taking Control of Castleman Disease: Leveraging Precision Medicine Technologies to Accelerate Rare Disease Research by Newman, Samantha Kass, Jayanthan, Raj K, Mitchell, Grant W, Carreras Tartak, Jossie A, Croglio, Michael P, Suarez, Alexander, Liu, Amy Y, Razzo, Beatrice M, Oyeniran, Enny, Ruth, Jason R, Fajgenbaum, David C

“…Castleman disease (CD) is a rare and heterogeneous disorder characterized by lymphadenopathy that may occur in a single lymph node (unicentric) or multiple…”
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A Phase 2, Single-Arm, Non-Inferiority Study of Limited-Duration Teclistamab for Relapsed and Refractory Multiple Myeloma (LimiTec) by Razzo, Beatrice, Grady, Connor, Susanibar-Adaniya, Sandra, Waxman, Adam, Vogl, Dan T., Cohen, Adam D., Stadtmauer, Edward A., Hwang, Wei-Ting, Garfall, Alfred L.

“…Background and Significance: Teclistamab, a BCMA-directed T-cell engager (anti-BCMAxCD3 bispecific antibody), is currently approved for relapsed/refractory…”
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COVID‐19 outcomes in hospitalized patients with active cancer: Experiences from a major New York City health care system by Fu, Chen, Stoeckle, James H., Masri, Lena, Pandey, Abhishek, Cao, Meng, Littman, Dalia, Rybstein, Marissa, Saith, Sunil E., Yarta, Kinan, Rohatgi, Abhinav, Makarov, Danil V., Sherman, Scott E., Morrissey, Christy, Jordan, Alexander C., Razzo, Beatrice, Theprungsirikul, Poy, Tsai, Joseph, Becker, Daniel J.

“…Background The authors sought to study the risk factors associated with severe outcomes in hospitalized coronavirus disease 2019 (COVID‐19) patients with…”
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Phase 2 Study of Belantamab Mafodotin As Pre- and Post-Stem Cell Transplant Consolidation and Maintenance (BLAST study) for Multiple Myeloma Patients in First Remission by Cohen, Adam D, Garfall, Alfred L, Susanibar-Adaniya, Sandra Patricia, Vogl, Dan T., Waxman, Adam, De Mesa, Oksana, Kane, Elizabeth, Nichols, Charles, Razzo, Beatrice, Stadtmauer, Edward A.

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Abstract 993: Chemotherapy enhances exosome secretion via upregulation of cholesterol metabolism in acute myeloid leukemia by Hong, Chang-Sook, Jeong, Emily J., Razzo, Beatrice, Boyiadzis, Michael, Whiteside, Theresa L.

“…Abstract Therapies for Acute Myelogenous Leukemia (AML) have not been successful largely due to disease recurrence after chemotherapy. Recent studies showed…”
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Abstract 2049: HNSCC-derived exosomes promote angiogenesis and tumor progression through reprogramming of the tumor microenvironment in vitro and in vivo by Ludwig, Nils, Yerneni, Saigopalakrishna S., Razzo, Beatrice M., Whiteside, Theresa L.

“…Abstract Head and neck squamous cell carcinoma (HNSCC) is the seventh most common malignant disease. For solid tumors, such as HNSCC, an adequate blood supply…”
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Chimeric Antigen Receptor T Cells in the Treatment of Multiple Myeloma by Hasanali, Zainul S., Razzo, Beatrice, Susanibar-Adaniya, Sandra P., Garfall, Alfred L., Stadtmauer, Edward A., Cohen, Adam D.

“…Chimeric antigen receptor T cells (CARTs) represent another powerful way to leverage the immune system to fight malignancy. Indeed, in multiple myeloma, the…”
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Abstract B34: TGF-β-rich tumor-derived exosomes promote a proangiogenic phenotype in HNSCC by Ludwig, Nils, Yerneni, Saigopalakrishna S., Azambuja, Juliana H., Razzo, Beatrice M., Hinck, Cynthia S., Pietrowska, Monika, Hinck, Andrew, Whiteside, Theresa L.

“…Abstract TGF-β is a key regulator for tumor initiation and progression in head and neck squamous cell carcinoma (HNSCC). Tumor-derived exosomes (TEX) contain…”
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Abstract 1748: Head and neck cancer-derived exosomes facilitate carcinogenesis in the murine 4NQO chemically induced oropharyngeal cancer by Razzo, Beatrice M., Hong, Chang-Sook, Fabian, Kellsye P., Ludwig, Nils, Sharma, Priyanka, Storkus, Walter J., Whiteside, Theresa L.

“…Abstract Purpose: An increasing body of evidence suggests that tumor-derived exosomes (TEX) promote tumor formation and progression. This study aims to show…”
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Hispanic or Latin American Ancestry Is Associated with a Similar Genomic Profile and a Trend Toward Inferior Outcomes in Newly Diagnosed Multiple Myeloma As Compared to Non-Hispanic White Patients in the Multiple Myeloma Research Foundation (MMRF) CoMMpassstudy by Williams, Louis, Blaney, Patrick, Boyle, Eileen M, Ghamlouch, Hussein, Wang, Yubao, Choi, Jinyoung, Bauer, Michael A, Siegel, Ariel, Stoeckle, James, Razzo, Beatrice, Auclair, Daniel, Kaminetzky, David, Braunstein, Marc, Bruno, Benedetto, Arbini, Arnaldo A., Walker, Brian A, Davies, Faith E., Morgan, Gareth J

“…Introduction Large clinical data sets suggest that the natural history and prognosis of newly diagnosed multiple myeloma (NDMM) differs between patients of…”
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Multiomic Mapping of Copy Number and Structural Variation on Chromosome 1 (Chr1) Highlights Multiple Recurrent Disease Drivers by Blaney, Patrick, Boyle, Eileen M, Wang, Yubao, Ghamlouch, Hussein, Choi, Jinyoung, Williams, Louis, James, Stoeckle, Siegel, Ariel, Razzo, Beatrice, Braunstein, Marc, Kaminetzky, David, Arbini, Arnaldo A, Bruno, Benedetto, Corre, Jill, Montes, Lydia, Auclair, Daniel, Davies, Faith E., Tsirigos, Aristotelis, Rustad, Even H, Maura, Francesco, Landgren, Ola, Bauer, Michael A, Walker, Brian, Morgan, Gareth

“…Introduction Copy number abnormalities (CNA) and structural variants (SV) are crucial to driving cancer progression and in multiple myeloma (MM). Chr1 CNA are…”
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Unifying the Definition of High-Risk in Multiple Myeloma by Siegel, Ariel, Boyle, Eileen M, Blaney, Patrick, Wang, Yubao, Ghamlouch, Hussein, Choi, Jinyoung, Caro, Jessica, Williams, Louis, Razzo, Beatrice, Arbini, Arnaldo A., Braunstein, Marc, Kaminetzky, David, Auclair, Daniel, Pawlyn, Charlotte, Cairns, David, Jackson, Graham, Walker, Brian, Bruno, Benedetto, Morgan, Gareth J., Davies, Faith E.

“…Introduction: There is considerable heterogeneity in the clinical outcome of newly diagnosed multiple-myeloma (NDMM) with some patients having a good prognosis…”
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