Search Results - "Razumova, Maria V"

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue by Ruan, Jia-Ling, Tulloch, Nathaniel L, Razumova, Maria V, Saiget, Mark, Muskheli, Veronica, Pabon, Lil, Reinecke, Hans, Regnier, Michael, Murry, Charles E

“…BACKGROUND:Tissue engineering enables the generation of functional human cardiac tissue with cells derived in vitro in combination with biocompatible…”
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Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell‐Derived Progenitors by Ruan, Jia‐Ling, Tulloch, Nathaniel L., Saiget, Mark, Paige, Sharon L., Razumova, Maria V., Regnier, Michael, Tung, Kelvin Chan, Keller, Gordon, Pabon, Lil, Reinecke, Hans, Murry, Charles E.

“…Recent advances in pluripotent stem cell biology and directed differentiation have identified a population of human cardiovascular progenitors that give rise…”
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Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells by Yang, Kai-Chun, MD, Breitbart, Astrid, MD, De Lange, Willem J., PhD, Hofsteen, Peter, PhD, Futakuchi-Tsuchida, Akiko, BS, Xu, Joy, MSE, Schopf, Cody, BS, Razumova, Maria V., PhD, Jiao, Alex, PhD, Boucek, Robert, MD, Pabon, Lil, PhD, Reinecke, Hans, PhD, Kim, Deok-Ho, PhD, Ralphe, J. Carter, MD, Regnier, Michael, PhD, Murry, Charles E., MD, PhD

“…Visual Abstract…”
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uPARAP function in cutaneous wound repair by Rohani, Maryam G, Chow, Yu-Hua, Razumova, Maria V, Ash, Samuel, Hung, Chi F, Schnapp, Lynn M

“…Optimal skin wound healing relies on tight balance between collagen synthesis and degradation in new tissue formation and remodeling phases. The endocytic…”
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Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture by Tulloch, Nathaniel L, Muskheli, Veronica, Razumova, Maria V, Korte, F Steven, Regnier, Michael, Hauch, Kip D, Pabon, Lil, Reinecke, Hans, Murry, Charles E

“…RATIONALE:The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these…”
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MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages by Rohani, Maryam G., McMahan, Ryan S., Razumova, Maria V., Hertz, Angie L., Cieslewicz, Maryelise, Pun, Suzie H., Regnier, Michael, Wang, Ying, Birkland, Timothy P., Parks, William C.

“…Matrix metalloproteinase-10 (MMP-10) is expressed by macrophages and epithelium in response to injury, but its functions in wound repair are unknown. We…”
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Different Myofilament Nearest-Neighbor Interactions Have Distinctive Effects on Contractile Behavior by Razumova, Maria V., Bukatina, Anna E., Campbell, Kenneth B.

“…Cooperativity in contractile behavior of myofilament systems almost assuredly arises because of interactions between neighboring sites. These interactions may…”
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2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure by Moussavi-Harami, Farid, Razumova, Maria V, Racca, Alice W, Cheng, Yuanhua, Stempien-Otero, April, Regnier, Michael

“…Abstract We are developing a novel treatment for heart failure by increasing myocardial 2 deoxy-ATP (dATP). Our studies in rodent models have shown that…”
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Stiffness-distortion sarcomere model for muscle simulation by Razumova, Maria V, Bukatina, Anna E, Campbell, Kenneth B

“…Departments of 1  Veterinary and Comparative Anatomy, Pharmacology and Physiology and 2  Biological Systems Engineering, Washington State University, Pullman,…”
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Nonlinear Myofilament Regulatory Processes Affect Frequency-Dependent Muscle Fiber Stiffness by Campbell, Kenneth B., Razumova, Maria V., Kirkpatrick, Robert D., Slinker, Bryan K.

“…To investigate the role of nonlinear myofilament regulatory processes in sarcomeric mechanodynamics, a model of myofilament kinetic processes, including thin…”
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Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts by Feest, Erik R, Steven Korte, F, Tu, An-yue, Dai, Jin, Razumova, Maria V, Murry, Charles E, Regnier, Michael

“…Abstract Many current pharmaceutical therapies for systolic heart failure target intracellular [Ca 2 + ] ([Ca 2 + ]i ) metabolism, or cardiac troponin C (cTnC)…”
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Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges by Razumova, Maria V, Shaffer, Justin F, Tu, An-Yue, Flint, Galina V, Regnier, Michael, Harris, Samantha P

“…Myosin binding protein-C (MyBP-C) is a thick-filament protein whose precise function within the sarcomere is not known. However, recent evidence from cMyBP-C…”
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Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges by Korte, F Steven, Feest, Erik R, Razumova, Maria V, Tu, An-Yue, Regnier, Michael

“…Calcium sensitivity of the force-pCa relationship depends strongly on sarcomere length (SL) in cardiac muscle and is considered to be the cellular basis of the…”
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Effects of low-level α-myosin heavy chain expression on contractile kinetics in porcine myocardium by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Norman, Holly S, Moss, Richard L

“…Myosin heavy chain (MHC) isoforms are principal determinants of work capacity in mammalian ventricular myocardium. The ventricles of large mammals including…”
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Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae by Razumova, Maria V, Bezold, Kristina L, Tu, An-Yue, Regnier, Michael, Harris, Samantha P

“…Myosin binding protein C (MyBP-C) is a thick-filament protein that limits cross-bridge cycling rates and reduces myocyte power output. To investigate…”
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N‐terminal phosphorylation of cardiac troponin‐I reduces length‐dependent calcium sensitivity of contraction in cardiac muscle by Rao, Vijay S., Korte, F. Steven, Razumova, Maria V., Feest, Erik R., Hsu, Hsiaoman, Irving, Thomas C., Regnier, Michael, Martyn, Donald A.

“…Key points •  β‐Adrenergic stimulation is an important control mechanism, matching cardiac output to venous return during increased metabolic demand. • …”
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Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Norman, Holly S, Patel, Jitandrakumar R, Moss, Richard L

“…The ventricles of small mammals express mostly alpha-myosin heavy chain (alpha-MHC), a fast isoform, whereas the ventricles of large mammals, including humans,…”
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Myosin S2 is not required for effects of myosin binding protein-C on motility by Shaffer, Justin F., Razumova, Maria V., Tu, An-Yue, Regnier, Michael, Harris, Samantha P.

“…The unique myosin binding protein-c “motif” near the N-terminus of myosin binding protein-C (MyBP-C) binds myosin S2. Previous studies demonstrated that…”
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Importance of myosin heavy chain isoform expression as a determinant of contraction kinetics in pig myocardium by Locher, Matthew R, Razumova, Maria V, Stelzer, Julian E, Moss, Richard L

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Effects of the N-terminal Domains of Myosin Binding Protein-C in an in Vitro Motility Assay by Razumova, Maria V., Shaffer, Justin F., Tu, An-Yue, Flint, Galina V., Regnier, Michael, Harris, Samantha P.

“…Myosin binding protein-C (MyBP-C) is a thick-filament protein whose precise function within the sarcomere is not known. However, recent evidence from cMyBP-C…”
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