Search Results - "Razo, Jennifer"

The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions by Harding, Fiona A., Stickler, Marcia M., Razo, Jennifer, DuBridge, Robert

“…Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for their targets, convey effector functions and enjoy robust…”
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Deep mutational scanning of an antibody against epidermal growth factor receptor using mammalian cell display and massively parallel pyrosequencing by Forsyth, Charles M., Juan, Veronica, Akamatsu, Yoshiko, DuBridge, Robert B., Doan, Minhtam, Ivanov, Alexander V., Ma, Zhiyuan, Polakoff, Dixie, Razo, Jennifer, Wilson, Keith, Powers, David B.

“…We developed a method for deep mutational scanning of antibody complementarity-determining regions (CDRs) that can determine in parallel the effect of every…”
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A β-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy by Harding, Fiona A, Liu, Amy D, Stickler, Marcia, Razo, O Jennifer, Chin, Regina, Faravashi, Nargol, Viola, Wendy, Graycar, Tom, Yeung, V Pete, Aehle, Wolfgang, Meijer, Daan, Wong, Stephanie, Rashid, M Harunur, Valdes, Ana M, Schellenberger, Volker

“…Antibody-directed enzyme prodrug therapy (ADEPT) delivers chemotherapeutic agents in high concentration to tumor tissue while minimizing systemic drug…”
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Abstract 3202: A probody drug conjugate targeting CD166 (ALCAM) enhances preclinical antitumor activity of a probody therapeutic targeting PD-1 by Scolan, Erwan Le, Tse, Tiffany, Krimm, Michael, Garner, Will, Assi, Hikmat, Razo, Jennifer, Wong, Laurie, Wong, Kenneth, Singson, Victoria, Leong, Jennifer, Diep, Linnea, Richardson, Jennifer, Schleyer, Siew, Daniel, Dylan, Belvin, Marcia, Kavanaugh, Michael

“…Abstract Immune checkpoint blockade therapies have been shown to induce potent and durable anti-tumor immunity in many cancer types. Nevertheless, not all…”
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Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents by Assi, Hikmat H, Wong, Chihunt, Tipton, Kimberly A, Mei, Li, Wong, Ken, Razo, Jennifer, Chan, Chanty, Howng, Bruce, Sagert, Jason, Krimm, Michael, Diep, Linnea, Jang, Andrew, Nguyen, Margaret T, Lapuyade, Nicole, Singson, Victoria, Villanueva, Ruth, Paidhungat, Madan, Liu, Shouchun, Rangan, Vangipuram, Vasiljeva, Olga, West, James W, Richardson, Jennifer H, Irving, Bryan, Daniel, Dylan, Belvin, Marcia, Kavanaugh, W Michael

“…Immune-checkpoint blockade has revolutionized cancer treatment. However, most patients do not respond to single-agent therapy. Combining checkpoint inhibitors…”
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Abstract A203: CD3-EGFR bispecific Probody™ therapeutics induced tumor regressions and increased therapeutic window in preclinical studies by LaPorte, Sherry L., Hostetter, Daniel R., Wong, Laurie, Razo, Jennifer, Diep, Linnea, White, Clayton W., Richardson, Jennifer H., Kavanaugh, W. Michael, Irving, Bryan A.

“…Abstract T cell-engaging bispecific antibodies (TCBs) represent a highly potent modality to direct the activity of cytotoxic T cells to tumors. TCBs are…”
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An In Vitro Human Cell–Based Assay to Rank the Relative Immunogenicity of Proteins by Stickler, Marcia, Rochanayon, Narapon, Razo, O. Jennifer, Mucha, Jeanette, Gebel, Wendy, Faravashi, Nargol, Chin, Regina, Holmes, Susan, Harding, Fiona A.

“…A method to rank proteins based on their relative immunogenicity has been devised. A statistical analysis of peptide-specific responses in large human donor…”
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Human population-based identification of CD4 + T-cell peptide epitope determinants by Stickler, Marcia, Chin, Regina, Faravashi, Nargol, Gebel, Wendy, Razo, O.Jennifer, Rochanayon, Narapon, Power, Scott, Valdes, Ana M, Holmes, Susan, Harding, Fiona A

“…A human cell-based method to identify functional CD4 + T-cell epitopes in any protein has been developed. Proteins are tested as synthetic 15-mer peptides…”
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