Free-radical-scavenging principles from Phlomis caucasica
Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin ( 1 ), chrysoeriol 7- O -rutinoside ( 2 ), kaempferol 3- O -glucoside ( 3 ), chrysoeriol 7- O -glucoside ( 4 ) and naringenin ( 5 ), and two phenylethanoid glycosides, forsythoside B ( 6 ) and acteoside ( 7 ) were isol...
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| Published in: | Journal of natural medicines Vol. 62; no. 4; pp. 464 - 466 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Japan
Springer Japan
01-10-2008
|
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (
1
), chrysoeriol 7-
O
-rutinoside (
2
), kaempferol 3-
O
-glucoside (
3
), chrysoeriol 7-
O
-glucoside (
4
) and naringenin (
5
), and two phenylethanoid glycosides, forsythoside B (
6
) and acteoside (
7
) were isolated from the methanol extract of the aerial parts of the Iranian medicinal plant
Phlomis caucasica
by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of
1
–
7
were assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. Among these compounds, forsythoside B (
6
) and acteoside (
7
) were found to be the most potent antioxidants with the RC
50
values of 4.97 and 4.27 μg/ml, respectively. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1340-3443 1861-0293 |
| DOI: | 10.1007/s11418-008-0255-y |