Search Results - "Razak, Khaleel"

Altered auditory processing in a mouse model of fragile X syndrome by Rotschafer, Sarah, Razak, Khaleel

“…Abstract This study provides the first description of auditory cortical processing in a mouse model of Fragile X Syndrome (FXS). FXS is a genetic cause of…”
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Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome by Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…Identification of comparable biomarkers in humans and validated animal models will facilitate pre-clinical to clinical therapeutic pipelines to treat…”
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Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice by Wen, Teresa H, Afroz, Sonia, Reinhard, Sarah M, Palacios, Arnold R, Tapia, Kendal, Binder, Devin K, Razak, Khaleel A, Ethell, Iryna M

“…Abstract Abnormal sensory responses associated with Fragile X Syndrome (FXS) and autism spectrum disorders include hypersensitivity and impaired habituation to…”
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The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders by Wen, Teresa H, Binder, Devin K, Ethell, Iryna M, Razak, Khaleel A

“…Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence…”
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Adaptations for Substrate Gleaning in Bats: The Pallid Bat as a Case Study by Razak, Khaleel A

“…Substrate gleaning is a foraging strategy in which bats use a mixture of echolocation, prey-generated sounds, and vision to localize and hunt surface-dwelling…”
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Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice by Pirbhoy, Patricia S., Rais, Maham, Lovelace, Jonathan W., Woodard, Walker, Razak, Khaleel A., Binder, Devin K., Ethell, Iryna M.

“…Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD) exhibit cognitive impairments, social deficits, increased anxiety, and sensory…”
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Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome by Jonak, Carrie R., Lovelace, Jonathan W., Ethell, Iryna M., Razak, Khaleel A., Binder, Devin K.

“…Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability with symptoms that include increased anxiety and social and sensory…”
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Age-related changes in event related potentials, steady state responses and temporal processing in the auditory cortex of mice with severe or mild hearing loss by Rumschlag, Jeffrey A., Razak, Khaleel A.

“…Age-related changes in auditory processing affect the quality of life of older adults with and without hearing loss. To distinguish between the effects of…”
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Developmental studies in fragile X syndrome by Razak, Khaleel A, Dominick, Kelli C, Erickson, Craig A

“…Fragile X syndrome (FXS) is the most common single gene cause of autism and intellectual disabilities. Humans with FXS exhibit increased anxiety, sensory…”
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Neural Correlates of Auditory Hypersensitivity in Fragile X Syndrome by Razak, Khaleel A., Binder, Devin K., Ethell, Iryna M.

“…The mechanisms underlying the common association between autism spectrum disorders (ASD) and sensory processing disorders (SPD) are unclear, and treatment…”
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Developmental Changes in EEG Phenotypes in a Mouse Model of Fragile X Syndrome by Wen, Teresa H., Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…•Development of EEG phenotypes in Fmr1 KO mice was examined.•Baseline gamma power was increased in the frontal cortex at all ages tested.•N1 amplitude and…”
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Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome by Lovelace, Jonathan W, Rais, Maham, Palacios, Arnold R, Shuai, Xinghao S, Bishay, Steven, Popa, Otilia, Pirbhoy, Patricia S, Binder, Devin K, Nelson, David L, Ethell, Iryna M, Razak, Khaleel A

“…Abstract Fragile X syndrome (FXS) is a leading genetic cause of autism with symptoms that include sensory processing deficits. In both humans with FXS and a…”
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Accurate sound localization behavior in a gleaning bat, Antrozous pallidus by Brewton, Dustin, Gutierrez, Victoria, Razak, Khaleel A

“…Acute auditory processing in bats is typically associated with echolocation. A subset of bats, called gleaners, listens to prey-generated noise to hunt…”
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Developmental trajectory and sex differences in auditory processing in a PTEN-deletion model of autism spectrum disorders by Croom, Katilynne, Rumschlag, Jeffrey A., Molinaro, Gemma, Erickson, Michael A., Binder, Devin K., Huber, Kimberly M., Razak, Khaleel A.

“…Autism Spectrum Disorders (ASD) encompass a wide array of debilitating symptoms, including severe sensory deficits and abnormal language development. Sensory…”
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Systematic representation of sound locations in the primary auditory cortex by Razak, Khaleel A

“…The primary auditory cortex (A1) is involved in sound localization. A consistent observation in A1 is a clustered representation of binaural properties, but…”
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Sensory Processing Phenotypes in Fragile X Syndrome by Rais, Maham, Binder, Devin K., Razak, Khaleel A., Ethell, Iryna M.

“…Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual disability. It is a leading known genetic cause of autism. In addition to…”
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Arizona bark scorpion venom resistance in the pallid bat, Antrozous pallidus by Hopp, Bradley H, Arvidson, Ryan S, Adams, Michael E, Razak, Khaleel A

“…The pallid bat (Antrozous pallidus), a gleaning bat found in the western United States and Mexico, hunts a wide variety of ground-dwelling prey, including…”
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Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice by Jonak, Carrie R., Assad, Samantha A., Garcia, Terese A., Sandhu, Manbir S., Rumschlag, Jeffrey A., Razak, Khaleel A., Binder, Devin K.

“…Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability with symptoms that include increased anxiety and social and sensory…”
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Mechanisms of Sound Localization in Two Functionally Distinct Regions of the Auditory Cortex by Razak, Khaleel A, Yarrow, Stuart, Brewton, Dustin

“…The auditory cortex is necessary for sound localization. The mechanisms that shape bicoordinate spatial representation in the auditory cortex remain unclear…”
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A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders by Reinhard, Sarah M, Razak, Khaleel, Ethell, Iryna M

“…The extracellular matrix (ECM) is a critical regulator of neural network development and plasticity. As neuronal circuits develop, the ECM stabilizes synaptic…”
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