Search Results - "Raynham, TM"

Enantiomerically Pure α-Amino Acid Synthesis via Hydroboration−Suzuki Cross-Coupling by Collier, Philip N, Campbell, Andrew D, Patel, Ian, Raynham, Tony M, Taylor, Richard J. K

“…The Garner aldehyde-derived methylene alkene 5 and the corresponding benzyloxycarbonyl compound 25 undergo hydroboration with 9-BBN-H followed by…”
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The synthesis of novel amino acids via hydroboration-Suzuki cross coupling by Campbell, Andrew D., Raynham, Tony M., Taylor, Richard J.K.

“…The Garner aldehyde-derived methylene alkene has been hydroborated using 9-BBN and the resulting organoborane employed in palladium-catalysed Suzuki coupling…”
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Solution and solid-Phase synthesis of potent inhibitors of hepatitis C Virus NS3 proteinase by Beevers, Rebekah, Carr, Maria G, Jones, Philip S, Jordan, Steven, Kay, Paul B, Lazell, Robert C, Raynham, Tony M

“…A versatile route for the synthesis of homochiral α-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences…”
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Completely diastereoselective aziridination of α,β-unsaturated acids via intramolecular reaction of 3-acetoxyaminoquinazolin-4(3 H)-ones by Atkinson, Robert S, Draycott, Richard D, Hirst, David J, Parratt, Martin J, Raynham, Tony M

“…( R)-3-Amino-2-[1-(2-hydroxyethoxy)ethyl]quinazolin-4(3 H)-one 10 was prepared in 62% yield without the need for chromatography and O-cinnamoylated; reaction…”
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The identification of α-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase by BENNETT, J. M, CAMPBELL, A. D, KAY, P. B, O'BRIEN, M. A, KING-UNDERWOOD, J, RAYNHAM, T. M, WILKINSON, C. S, WILKINSON, T. C. I, WILSON, F. X, CAMPBELL, A. J, CARR, M. G, DUNSDON, R. M, GREENING, J. R, HURST, D. N, JENNINGS, N. S, JONES, P. S, JORDAN, S

“…Peptides based upon the non-prime side residues of the NS4A-4B cleavage site of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha-ketoamide moiety…”
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Acid-catalysed ring-opening of N-(3, 4-dihydro-4-oxoquinazolin-3-yl)-substituted aziridines: aziridine ring-opening with retention of configuration by Atkinson, Robert S., Ayscough, Andrew P., Gattrell, William T., Raynham, Tony M.

“…The presence of the quinazolin-4(3H)-one (Q) ring in 1-(Q)-2-vinylaziridine ( 2) can be used to control the stereochemistry of the 3-membered ring-opening;…”
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Ring-opening of chiral N-(3,4-dihydro-4-oxoquinazolin-3-yl)-substituted aziridines (Q ∗-substituted aziridines): access to Q ∗-free chirons by Atkinson, Robert S, Ayscough, Andrew P, Gattrell, William T, Raynham, Tony M

“…The presence of the quinazolin-4(3H)-one ring (Q ∗) in N-(Q ∗)-aziridines facilitates ring-opening by nucleophiles: removal of the Q ∗ group from enantiopure…”
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The Design and Synthesis of Potent Inhibitors of Hepatitis C Virus NS3–4A Proteinase by Attwood, MR, Bennett, JM, Campbell, AD, Canning, GGM, Carr, MG, Conway, E, Dunsdon, RM, Greening, JR, Jones, PS, Kay, PB, Handa, BK, Hurst, DN, Jennings, NS, Jordan, S, Keech, E, O'Brien, MA, Overton, HA, King-Underwood, J, Raynham, TM, Stenson, KP, Wilkinson, CS, Wilkinson, TCI, Wilson, FX

“…Hepatitis C virus (HCV) is the cause of the majority of transfusion-associated hepatitis and a significant proportion of community-acquired hepatitis…”
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Elaboration of a cyclohexadienyl triflate iron π-complex by palladium-catalysed coupling by Attwood, Michael R., Raynham, Tony M., Smyth, Donald G., Stephenson, G.Richard

“…Optimisation of Stille coupling between tricarbonyl[1,2,3,4-η-cyclohexadien-1-yl triflate]iron(0) and tributylvinyltin forms the 1-ethenyl-substituted…”
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